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The amino acid-derived metabolite N-hydroxypipecolic acid (NHP) travels from infected to systemic leaves, where it activates salicylic acid (SA) biosynthesis through the isochorismate pathway. The resulting increased SA levels are essential for induction of a large set of SAR marker genes and full SAR establishment. In this study, we show that pharmacological treatment of Arabidopsis thaliana with NHP induces a subset of SAR-related genes even in the SA induction-deficient2 (sid2\/isochorismate synthase1) mutant, which is devoid of NHP-induced SA. NHP-mediated induction is abolished in sid2-1 NahG plants, in which basal SA levels are degraded. The SA receptor NON-EXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) and its interacting TGACG SEQUENCE-SPECIFIC BINDING PROTEIN (TGA) transcription factors are required for the NHP-mediated induction of SAR genes at resting SA levels. Isothermal titration analysis determined a KD of 7.9\u2009\u00b1\u20090.5 \u00b5M for the SA\/NPR1 complex, suggesting that basal levels of SA would not bind to NPR1 unless yet unknown potentially NHP-induced processes increase the affinity. Moreover, the nucleocytoplasmic protein PHYTOALEXIN DEFICIENT4 is required for a slight NHP-mediated increase in NPR1 protein levels and NHP-induced expression of SAR-related genes. Our experiments have unraveled that NHP requires basal SA and components of the SA signaling pathway to induce SAR genes. Still, the mechanism of NHP perception remains enigmatic.<\/jats:p>","DOI":"10.1093\/plphys\/kiab433","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T15:13:55Z","timestamp":1631546035000},"page":"2803-2819","source":"Crossref","is-referenced-by-count":43,"title":["N-hydroxypipecolic acid-induced transcription requires the salicylic acid signaling pathway at basal SA levels"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-6083","authenticated-orcid":false,"given":"Aswin","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Plant Molecular Biology and Physiology, Albrecht-von-Haller Institute for Plant Sciences, Georg-August University G\u00f6ttingen, Julia-Lermontowa-Weg 3, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-8546","authenticated-orcid":false,"given":"Isha","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Plant Molecular Biology and Physiology, Albrecht-von-Haller Institute for Plant Sciences, Georg-August University G\u00f6ttingen, Julia-Lermontowa-Weg 3, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Vo\u00df","sequence":"additional","affiliation":[{"name":"Institute of Organic and Biomolecular Chemistry, Georg-August University G\u00f6ttingen, Tammannstr. 2, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-391X","authenticated-orcid":false,"given":"Pascal","family":"Mrozek","sequence":"additional","affiliation":[{"name":"Department of Plant Molecular Biology and Physiology, Albrecht-von-Haller Institute for Plant Sciences, Georg-August University G\u00f6ttingen, Julia-Lermontowa-Weg 3, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-5455","authenticated-orcid":false,"given":"Sabin","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Molecular Enzymology, G\u00f6ttingen Centre for Molecular Biosciences and Albrecht-von-Haller Institute, Georg-August University G\u00f6ttingen, Julia-Lermontowa-Weg 3, 37077 G\u00f6ttingen, Germany"},{"name":"Department of Structural Dynamics, Max-Planck-Institute for Biophysical Chemistry, Am Fa\u00dfberg 11, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Thurow","sequence":"additional","affiliation":[{"name":"Department of Plant Molecular Biology and Physiology, Albrecht-von-Haller Institute for Plant Sciences, Georg-August University G\u00f6ttingen, Julia-Lermontowa-Weg 3, 37077 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