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Among plant defensive compounds against phytophagous arthropods, cyanide-derived products are toxic molecules that directly target pest physiology. Here, we identified the Arabidopsis (Arabidopsis thaliana) gene encoding hydroxynitrile lyase (AtHNL, At5g10300) as one gene induced in response to spider mite (Tetranychus urticae) infestation. AtHNL catalyzes the reversible interconversion between cyanohydrins and derived carbonyl compounds with free cyanide. AtHNL loss- and gain-of-function Arabidopsis plants showed that specific activity of AtHNL using mandelonitrile as substrate was higher in the overexpressing lines than in wild-type (WT) and mutant lines. Concomitantly, mandelonitrile accumulated at higher levels in mutant lines than in WT plants and was significantly reduced in the AtHNL overexpressing lines. After mite infestation, mandelonitrile content increased in WT and overexpressing plants but not in mutant lines, while hydrogen cyanide (HCN) accumulated in the three infested Arabidopsis genotypes. Feeding bioassays demonstrated that the AtHNL gene participated in Arabidopsis defense against T. urticae. The reduced leaf damage detected in the AtHNL overexpressing lines reflected the mite\u2019s reduced ability to feed on leaves, which consequently restricted mite fecundity. In turn, mites upregulated TuCAS1 encoding \u03b2-cyanoalanine synthase to avoid the respiratory damage produced by HCN. This detoxification effect was functionally demonstrated by reduced mite fecundity observed when dsRNA-TuCAS-treated mites fed on WT plants and hnl1 mutant lines. These findings add more players in the Arabidopsis\u2013T. urticae interplay to overcome mutual defenses.<\/jats:p>","DOI":"10.1093\/plphys\/kiac170","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T19:09:27Z","timestamp":1650308967000},"page":"2244-2258","source":"Crossref","is-referenced-by-count":23,"title":["Hydroxynitrile lyase defends Arabidopsis against<i>Tetranychus urticae<\/i>"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-498X","authenticated-orcid":false,"given":"Ana","family":"Arnaiz","sequence":"first","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas, Universidad Polit\u00e9cnica de Madrid (UPM)-Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria , Campus de Montegancedo, 20223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-6227","authenticated-orcid":false,"given":"M Estrella","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas, Universidad Polit\u00e9cnica de Madrid (UPM)-Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria , Campus de Montegancedo, 20223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-9995","authenticated-orcid":false,"given":"Irene","family":"Rosa-Diaz","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas, Universidad Polit\u00e9cnica de Madrid (UPM)-Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria , Campus de Montegancedo, 20223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Garcia","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis, Consejo Superior de Investigaciones Cient\u00edficas and Universidad de Sevilla , 41092 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4492-8607","authenticated-orcid":false,"given":"Sameer","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Western Ontario , London, Ontario N6A 5B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-6574","authenticated-orcid":false,"given":"Saul","family":"Vallejos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos , Burgos 09001, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-7446","authenticated-orcid":false,"given":"Cecilia","family":"Gotor","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis, Consejo Superior de Investigaciones Cient\u00edficas and Universidad de Sevilla , 41092 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-5872","authenticated-orcid":false,"given":"Manuel","family":"Martinez","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas, Universidad Polit\u00e9cnica de Madrid (UPM)-Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria , Campus de Montegancedo, 20223 Madrid, Spain"},{"name":"Departamento de Biotecnolog\u00eda-Biolog\u00eda Vegetal, Escuela T\u00e9cnica Superior de Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas, UPM , 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-8796","authenticated-orcid":false,"given":"Vojislava","family":"Grbic","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Western Ontario , London, Ontario N6A 5B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-902X","authenticated-orcid":false,"given":"Isabel","family":"Diaz","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas, Universidad Polit\u00e9cnica de Madrid (UPM)-Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria , Campus de Montegancedo, 20223 Madrid, Spain"},{"name":"Departamento de Biotecnolog\u00eda-Biolog\u00eda Vegetal, Escuela T\u00e9cnica Superior de Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas, UPM , 28040 Madrid, 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