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POPEYE (PYE) is an iron responsive transcription factor that positively regulates the iron deficiency response, while also repressing genes essential for maintaining iron homeostasis. However, little is known about how PYE plays such contradictory roles. Under iron-deficient conditions, pPYE:GFP accumulates in the root pericycle while pPYE:PYE\u2013GFP is localized to the nucleus in all Arabidopsis (Arabidopsis thaliana) root cells, suggesting that PYE may have cell-specific dynamics and functions. Using scanning fluorescence correlation spectroscopy and cell-specific promoters, we found that PYE\u2013GFP moves between different cells and that the tendency for movement corresponds with transcript abundance. While localization to the cortex, endodermis, and vasculature is required to manage changes in iron availability, vasculature and endodermis localization of PYE\u2013GFP protein exacerbated pye-1 defects and elicited a host of transcriptional changes that are detrimental to iron mobilization. Our findings indicate that PYE acts as a positive regulator of iron deficiency response by regulating iron bioavailability differentially across cells, which may trigger iron uptake from the surrounding rhizosphere and impact root energy metabolism.<\/jats:p>","DOI":"10.1093\/plphys\/kiac357","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T14:41:37Z","timestamp":1659537697000},"page":"2017-2032","source":"Crossref","is-referenced-by-count":14,"title":["POPEYE intercellular localization mediates cell-specific iron deficiency responses"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-4058","authenticated-orcid":false,"given":"DurreShahwar","family":"Muhammad","sequence":"first","affiliation":[{"name":"Department of Plant and Microbial Biology, North Carolina State University , Raleigh, North Carolina 27695, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-321X","authenticated-orcid":false,"given":"Natalie M","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, North Carolina State University , Raleigh, North Carolina 27695, USA"},{"name":"Biomathematics Graduate Program , Raleigh, North Carolina 27695, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-8713","authenticated-orcid":false,"given":"Samiul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, North Carolina State University , Raleigh, North Carolina 27695, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-9707","authenticated-orcid":false,"given":"Cranos M","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, North Carolina State University , Raleigh, North Carolina 27695, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-2367","authenticated-orcid":false,"given":"Rosangela","family":"Sozzani","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, North Carolina State University , Raleigh, North Carolina 27695, USA"},{"name":"Biomathematics Graduate Program , Raleigh, North Carolina 27695, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-0195","authenticated-orcid":false,"given":"Terri A","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, North Carolina State University , Raleigh, North Carolina 27695, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"2023080304574903600_kiac357-B2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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