{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:33:55Z","timestamp":1791347635323,"version":"4.3.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972428"],"award-info":[{"award-number":["31972428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172550"],"award-info":[{"award-number":["32172550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Arabidopsis (Arabidopsis thaliana) PROTEIN ARGININE METHYLTRANSFERASE5 (PRMT5), a highly conserved arginine (Arg) methyltransferase protein, regulates multiple aspects of the growth, development, and environmental stress responses by methylating Arg in histones and some mRNA splicing-related proteins in plants. Hydrogen sulfide (H2S) is a recently characterized gasotransmitter that also regulates various important physiological processes. l-cysteine desulfhydrase (LCD) is a key enzyme of endogenous H2S production. However, our understanding of the upstream regulatory mechanisms of endogenous H2S production is limited in plant cells. Here, we confirmed that AtPRMT5 increases the enzymatic activity of AtLCD through methylation modifications during stress responses. Both atprmt5 and atlcd mutants were sensitive to cadmium (Cd2+), whereas the overexpression (OE) of AtPRMT5 or AtLCD enhanced the Cd2+ tolerance of plants. AtPRMT5 methylated AtLCD at Arg-83, leading to a significant increase in AtLCD enzymatic activity. The Cd2+ sensitivity of atprmt5-2 atlcd double mutants was consistent with that of atlcd plants. When AtPRMT5 was overexpressed in the atlcd mutant, the Cd2+ tolerance of plants was significantly lower than that of AtPRMT5-OE plants in the wild-type background. These results were confirmed in pharmacological experiments. Thus, AtPRMT5 methylation of AtLCD increases its enzymatic activity, thereby strengthening the endogenous H2S signal and ultimately improving plant tolerance to Cd2+ stress. These findings provide further insights into the substrates of AtPRMT5 and increase our understanding of the regulatory mechanism upstream of H2S signals.<\/jats:p>","DOI":"10.1093\/plphys\/kiac376","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T14:18:41Z","timestamp":1660659521000},"page":"2637-2650","source":"Crossref","is-referenced-by-count":37,"title":["AtPRMT5-mediated AtLCD methylation improves Cd2+ tolerance via increased H2S production in Arabidopsis"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-1497","authenticated-orcid":false,"given":"Haiyan","family":"Cao","sequence":"first","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-1972","authenticated-orcid":false,"given":"Yali","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-719X","authenticated-orcid":false,"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1421-0290","authenticated-orcid":false,"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-3616","authenticated-orcid":false,"given":"Danmei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-0753","authenticated-orcid":false,"given":"Xiaofeng","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences , 100101 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences , 100101 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5533-6201","authenticated-orcid":false,"given":"Zhuping","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-3399","authenticated-orcid":false,"given":"Yanxi","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Life Science and Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University , 030006 Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"2022112910504354600_kiac376-B1","doi-asserted-by":"crossref","first-page":"110978","DOI":"10.1016\/j.ecoenv.2020.110978","article-title":"Dose dependent differential effects of toxic metal cadmium in tomato roots: role of endogenous hydrogen sulfide","volume":"203","author":"Alamri","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"2022112910504354600_kiac376-B2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ecoenv.2014.08.027","article-title":"Hydrogen sulfide alleviates cadmium-induced morpho-physiological and ultrastructural changes in Brassica napus","volume":"110","author":"Ali","year":"2014","journal-title":"Ecotoxicol Environ Saf"},{"key":"2022112910504354600_kiac376-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2008.12.013","article-title":"Protein arginine methylation in mammals: who, what, and why","volume":"33","author":"Bedford","year":"2009","journal-title":"Mol Cell"},{"key":"2022112910504354600_kiac376-B4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molcel.2005.04.003","article-title":"Arginine methylation an emerging regulator of protein function","volume":"18","author":"Bedford","year":"2005","journal-title":"Mol Cell"},{"key":"2022112910504354600_kiac376-B5","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1073\/pnas.0807974105","article-title":"Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation","volume":"106","author":"Bianca","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112910504354600_kiac376-B6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2016.11.003","article-title":"Arginine methylation: the coming of age","volume":"65","author":"Blanc","year":"2017","journal-title":"Mol Cell"},{"key":"2022112910504354600_kiac376-B7","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0140-6736(90)92201-R","article-title":"Renal effects of cadmium body burden of the general population","volume":"336","author":"Buchet","year":"1990","journal-title":"Lancet"},{"key":"2022112910504354600_kiac376-B8","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1093\/jxb\/erv368","article-title":"Hydrogen sulphide improves adaptation of Zea mays seedlings to iron deficiency","volume":"66","author":"Chen","year":"2015","journal-title":"J Exp Bot"},{"key":"2022112910504354600_kiac376-B9","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.molp.2020.01.004","article-title":"Hydrogen sulfide positively regulates abscisic acid signaling through persulfidation of SnRK2.6 in guard cells","volume":"13","author":"Chen","year":"2020","journal-title":"Mol Plant"},{"key":"2022112910504354600_kiac376-B10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jplph.2005.11.010","article-title":"Evolution and function of phytochelatin synthases","volume":"163","author":"Clemens","year":"2006","journal-title":"J Plant Physiol"},{"key":"2022112910504354600_kiac376-B11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-arplant-043015-112301","article-title":"Toxic heavy metal and metalloid accumulation in crop plants and foods","volume":"67","author":"Clemens","year":"2016","journal-title":"Annu Rev Plant Biol"},{"key":"2022112910504354600_kiac376-B12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","article-title":"Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana","volume":"16","author":"Clough","year":"1998","journal-title":"Plant J"},{"key":"2022112910504354600_kiac376-B13","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.tplants.2019.08.003","article-title":"Hydrogen sulfide: a new warrior against abiotic stress","volume":"24","author":"Corpas","year":"2019","journal-title":"Trends Plant Sci"},{"key":"2022112910504354600_kiac376-B14","doi-asserted-by":"crossref","first-page":"e109669","DOI":"10.1371\/journal.pone.0109669","article-title":"Cadmium-induced hydrogen sulfide synthesis is involved in cadmium tolerance in Medicago sativa by reestablishment of reduced (homo)glutathione and reactive oxygen species homeostasis","volume":"9","author":"Cui","year":"2014","journal-title":"PLoS ONE"},{"key":"2022112910504354600_kiac376-B15","doi-asserted-by":"crossref","first-page":"19114","DOI":"10.1073\/pnas.1009669107","article-title":"Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing","volume":"107","author":"Deng","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112910504354600_kiac376-B16","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/tpj.13627","article-title":"The Ca2+\/calmodulin2-binding transcription factor TGA3 elevates LCD expression and H2S production to bolster Cr6+ tolerance in Arabidopsis","volume":"91","author":"Fang","year":"2017","journal-title":"Plant J"},{"key":"2022112910504354600_kiac376-B17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/tpj.12380","article-title":"SKB1\/PRMT5-mediated histone H4R3 dimethylation of Ib subgroup bHLH genes negatively regulates iron homeostasis in Arabidopsis thaliana","volume":"77","author":"Fan","year":"2014","journal-title":"Plant J"},{"key":"2022112910504354600_kiac376-B18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/jxb\/erx419","article-title":"Control of proline accumulation under drought via a novel pathway comprising the histone methylase CAU1 and the transcription factor ANAC055","volume":"69","author":"Fu","year":"2018","journal-title":"J Exp Bot"},{"key":"2022112910504354600_kiac376-B19","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1105\/tpc.113.113886","article-title":"Arabidopsis histone methylase CAU1\/PRMT5\/SKB1 acts as an epigenetic suppressor of the calcium signaling gene CAS to mediate stomatal closure in response to extracellular calcium","volume":"25","author":"Fu","year":"2013","journal-title":"Plant Cell"},{"key":"2022112910504354600_kiac376-B20","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1073\/pnas.86.18.6838","article-title":"Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)","volume":"86","author":"Grill","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112910504354600_kiac376-B21","doi-asserted-by":"crossref","first-page":"21211","DOI":"10.1073\/pnas.1011987107","article-title":"Type II protein arginine methyltransferase 5 (PRMT5) is required for circadian period determination in Arabidopsis thaliana","volume":"107","author":"Hong","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112910504354600_kiac376-B22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.molcel.2017.06.031","article-title":"Nitric oxide regulates protein methylation during stress responses in plants","volume":"67","author":"Hu","year":"2017","journal-title":"Mol Cell"},{"key":"2022112910504354600_kiac376-B23","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3389\/fpls.2020.01283","article-title":"H2S regulation of metabolism in Cucumber in response to salt-stress through transcriptome and proteome analysis","volume":"11","author":"Jiang","year":"2020","journal-title":"Front Plant Sci"},{"key":"2022112910504354600_kiac376-B24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plaphy.2012.10.017","article-title":"Hydrogen sulfide interacting with abscisic acid in stomatal regulation responses to drought stress in Arabidopsis","volume":"62","author":"Jin","year":"2013","journal-title":"Plant Physiol Biochem"},{"key":"2022112910504354600_kiac376-B25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jgg.2016.02.007","article-title":"The protein Arginine methylase 5 (PRMT5\/SKB1) gene is required for the maintenance of root stem cells in response to DNA damage","volume":"43","author":"Li","year":"2016","journal-title":"J Genet Genomics"},{"key":"2022112910504354600_kiac376-B26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.arplant.043008.091939","article-title":"Histone methylation in higher plants","volume":"61","author":"Liu","year":"2010","journal-title":"Annu Rev Plant Biol"},{"key":"2022112910504354600_kiac376-B27","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.molp.2016.10.010","article-title":"AtPRMT5 regulates shoot regeneration through mediating histone H4R3 dimethylation on KRPs and pre-mRNA splicing of RKP in Arabidopsis","volume":"9","author":"Liu","year":"2016","journal-title":"Mol Plant"},{"key":"2022112910504354600_kiac376-B28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1158\/0008-5472.CAN-15-1766","article-title":"Arginine methylation of SREBP1a via PRMT5 promotes de novo lipogenesis and tumor growth","volume":"76","author":"Liu","year":"2016","journal-title":"Cancer Res"},{"key":"2022112910504354600_kiac376-B29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11103-019-00834-w","article-title":"The role of H2S in low temperature-induced cucurbitacin C increases in cucumber","volume":"99","author":"Liu","year":"2019","journal-title":"Plant Mol Biol"},{"key":"2022112910504354600_kiac376-B30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta","volume":"25","author":"Livak","year":"2001","journal-title":"Method. Methods"},{"key":"2022112910504354600_kiac376-B31","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/pce.12092","article-title":"Hydrogen sulphide may be a novel downstream signal molecule in nitric oxide-induced heat tolerance of maize (Zea mays L.) seedlings","volume":"36","author":"Li","year":"2013","journal-title":"Plant Cell Environ"},{"key":"2022112910504354600_kiac376-B32","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s12870-020-02687-8","article-title":"Hydrogen sulfide negatively regulates CD-induced cell death in cucumber (Cucumis sativus L) root tip cells","volume":"20","author":"Luo","year":"2020","journal-title":"BMC Plant Biol"},{"key":"2022112910504354600_kiac376-B33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fpls.2017.00232","article-title":"Cadmium disrupts the balance between hydrogen peroxide and superoxide radical by regulating endogenous hydrogen sulfide in the root tip of Brassica rapa","volume":"8","author":"Lv","year":"2017","journal-title":"Front Plant Sci"},{"key":"2022112910504354600_kiac376-B34","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0960-9822(01)00592-9","article-title":"Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln","volume":"11","author":"Meister","year":"2001","journal-title":"Curr Biol"},{"key":"2022112910504354600_kiac376-B35","doi-asserted-by":"crossref","first-page":"14078","DOI":"10.1038\/srep14078","article-title":"Hydrogen sulfide modulates cadmium-induced physiological and biochemical responses to alleviate cadmium toxicity in rice","volume":"5","author":"Mostofa","year":"2015","journal-title":"Sci Rep"},{"key":"2022112910504354600_kiac376-B36","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1242\/jeb.021303","article-title":"Hypotaurine and sulfhydryl-containing antioxidants reduce H2S toxicity in erythrocytes from a marine invertebrate","volume":"211","author":"Ortega","year":"2008","journal-title":"J Exp Biol"},{"key":"2022112910504354600_kiac376-B37","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1055\/s-2007-965424","article-title":"Characterization of cysteine-degrading and H2S-releasing enzymes of higher plants - from the field to the test tube and back","volume":"9","author":"Papenbrock","year":"2007","journal-title":"Plant Biol (Stuttg)"},{"key":"2022112910504354600_kiac376-B38","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1104\/pp.107.099531","article-title":"Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis","volume":"144","author":"Pei","year":"2007","journal-title":"Plant Physiol"},{"key":"2022112910504354600_kiac376-B39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11104-015-2475-8","article-title":"H2S acting as a downstream signaling molecule of SA regulates Cd tolerance in Arabidopsis","volume":"393","author":"Qiao","year":"2015","journal-title":"Plant and Soil"},{"key":"2022112910504354600_kiac376-B40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11104-015-2643-x","article-title":"CDPKs enhance Cd tolerance through intensifying H2S signal in Arabidopsis thaliana","volume":"398","author":"Qiao","year":"2016","journal-title":"Plant and Soil"},{"key":"2022112910504354600_kiac376-B41","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1111\/j.1742-4658.2005.04567.x","article-title":"Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thaliana","volume":"272","author":"Riemenschneider","year":"2005","journal-title":"FEBS J"},{"key":"2022112910504354600_kiac376-B42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature09470","article-title":"A methyl transferase links the circadian clock to the regulation of alternative splicing","volume":"468","author":"Sanchez","year":"2010","journal-title":"Nature"},{"key":"2022112910504354600_kiac376-B43","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1073\/pnas.0710423104","article-title":"Histone arginine methylation is required for vernalization-induced epigenetic silencing of FLC in winter-annual Arabidopsis thaliana","volume":"105","author":"Schmitz","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112910504354600_kiac376-B44","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1104\/pp.114.245373","article-title":"Hydrogen sulfide generated by L-cysteine desulfhydrase acts upstream of nitric oxide to modulate abscisic acid-dependent stomatal closure","volume":"166","author":"Scuffi","year":"2014","journal-title":"Plant Physiol"},{"key":"2022112910504354600_kiac376-B45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-3040.2011.02338.x","article-title":"Phytoextraction of toxic metals: a central role for glutathione","volume":"35","author":"Seth","year":"2012","journal-title":"Plant Cell Environ"},{"key":"2022112910504354600_kiac376-B46","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1105\/tpc.110.073874","article-title":"The Mg-Chelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA responsive genes of inhibition","volume":"22","author":"Shang","year":"2010","journal-title":"Plant Cell"},{"key":"2022112910504354600_kiac376-B47","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1365-2672.2012.05408.x","article-title":"Cadmium toxicity is alleviated by AtLCD and AtDCD in Escherichia coli","volume":"113","author":"Shen","year":"2012","journal-title":"J Appl Microbiol"},{"key":"2022112910504354600_kiac376-B48","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1105\/tpc.19.00826","article-title":"Persulfidation-based modification of cysteine desulfhydrase and the NADPH oxidase RBOHD controls guard cell abscisic acid signaling","volume":"32","author":"Shen","year":"2020","journal-title":"Plant Cell"},{"key":"2022112910504354600_kiac376-B49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.plaphy.2013.01.003","article-title":"Hydrogen sulfide alleviates cadmium toxicity through regulations of cadmium transport across the plasma and vacuolar membranes in Populus euphratica cells","volume":"65","author":"Sun","year":"2013","journal-title":"Plant Physiol Biochem"},{"key":"2022112910504354600_kiac376-B50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11240-006-9192-1","article-title":"Changes in phytochelatins and their biosynthetic intermediates in red spruce (Picea rubens Sarg.) cell suspension cultures under cadmium and zinc stress. Plant Cell","volume":"88","author":"Thangavel","year":"2007","journal-title":"Tissue Organ Cult"},{"key":"2022112910504354600_kiac376-B51","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-313X.2004.02219.x","article-title":"Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation","volume":"40","author":"Walter","year":"2004","journal-title":"Plant J"},{"key":"2022112910504354600_kiac376-B52","doi-asserted-by":"crossref","first-page":"123651","DOI":"10.1016\/j.jhazmat.2020.123651","article-title":"The multiple effects of hydrogen sulfide on cadmium toxicity in tobacco may be interacted with CaM signal transduction","volume":"403","author":"Wang","year":"2021","journal-title":"J Hazard Mater"},{"key":"2022112910504354600_kiac376-B53","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company, three\u2019s a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J"},{"key":"2022112910504354600_kiac376-B54","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/sj.emboj.7601647","article-title":"SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis","volume":"26","author":"Wang","year":"2007","journal-title":"EMBO J"},{"key":"2022112910504354600_kiac376-B55","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat Methods"},{"key":"2022112910504354600_kiac376-B56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11103-009-9507-9","article-title":"Over-expression of an AT-hook gene, AHL22, delays flowering and inhibits the elongation of the hypocotyl in Arabidopsis thaliana","volume":"71","author":"Xiao","year":"2009","journal-title":"Plant Mol Biol"},{"key":"2022112910504354600_kiac376-B57","article-title":"Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation","volume":"32","author":"Yang","year":"2018","journal-title":"FASEB J"},{"key":"2022112910504354600_kiac376-B58","doi-asserted-by":"crossref","first-page":"e83258","DOI":"10.1371\/journal.pone.0083258","article-title":"Histone H4R3 methylation catalyzed by SKB1\/PRMT5 is required for maintaining shoot apical meristem","volume":"8","author":"Yue","year":"2013","journal-title":"PLoS ONE"},{"key":"2022112910504354600_kiac376-B59","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1744-7909.2009.00885.x","article-title":"Hydrogen sulfide promotes root organogenesis in Ipomoea batatas, Salix matsudana and Glycine max","volume":"51","author":"Zhang","year":"2009","journal-title":"J Integr Plant Biol"},{"key":"2022112910504354600_kiac376-B60","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/pce.13685","article-title":"Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure","volume":"43","author":"Zhang","year":"2020","journal-title":"Plant Cell Environ"},{"key":"2022112910504354600_kiac376-B61","doi-asserted-by":"crossref","first-page":"804603","DOI":"10.1155\/2015\/804603","article-title":"Hydrogen sulfide alleviates cadmium-induced cell death through restraining ROS accumulation in roots of Brassica rapa L. ssp. pekinensis","volume":"2015","author":"Zhang","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"2022112910504354600_kiac376-B62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1104\/pp.19.01504","article-title":"WRKY13 enhances cadmium tolerance by promoting D-CYSTEINE DESULFHYDRASE and hydrogen sulfide production","volume":"183","author":"Zhang","year":"2020","journal-title":"Plant Physiol"},{"key":"2022112910504354600_kiac376-B63","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1105\/tpc.110.081356","article-title":"Arabidopsis floral initiator SKB1 confers high salt tolerance by regulating transcription and pre-mRNA splicing through altering histone H4R3 and small nuclear ribonucleoprotein LSM4 methylation","volume":"23","author":"Zhang","year":"2011","journal-title":"Plant Cell"},{"key":"2022112910504354600_kiac376-B64","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3389\/fpls.2018.01366","article-title":"Hydrogen sulfide mediates K+ and Na+ homeostasis in the roots of salt-resistant and salt-sensitive poplar species subjected to NaCl stress","volume":"9","author":"Zhao","year":"2018","journal-title":"Front Plant Sci"},{"key":"2022112910504354600_kiac376-B65","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J"},{"key":"2022112910504354600_kiac376-B66","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3389\/fpls.2018.01288","article-title":"Signaling molecule hydrogen sulfide improves seed germination and seedling growth of maize (Zea mays L.) under high temperature by inducing antioxidant system and osmolyte biosynthesis","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Plant Sci"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/plphys\/advance-article-pdf\/doi\/10.1093\/plphys\/kiac376\/45533689\/kiac376.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/190\/4\/2637\/47382220\/kiac376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/190\/4\/2637\/47382220\/kiac376.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T10:51:51Z","timestamp":1669719111000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/190\/4\/2637\/6668476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":66,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8,16]]},"published-print":{"date-parts":[[2022,11,28]]}},"URL":"https:\/\/doi.org\/10.1093\/plphys\/kiac376","relation":{},"ISSN":["0032-0889","1532-2548"],"issn-type":[{"value":"0032-0889","type":"print"},{"value":"1532-2548","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,8,16]]}}}