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However, the fine-tuned regulation of TGN components in plant defense and stress response has been not fully elucidated. Our study revealed that despite largely compromising penetration resistance, the loss-of-function mutation of the TGN component protein ECHIDNA (ECH) induced enhanced postinvasion resistance to powdery mildew in Arabidopsis thaliana. Genetic and transcriptome analyses and hormone profiling demonstrated that ECH loss resulted in salicylic acid (SA) hyperaccumulation via the ISOCHORISMATE SYNTHASE 1 biosynthesis pathway, thereby constitutively activating SA-dependent innate immunity that was largely responsible for the enhanced postinvasion resistance. Furthermore, the ech mutant displayed accelerated SA-independent spontaneous cell death and constitutive POWDERY MILDEW RESISTANCE 4-mediated callose depositions. In addition, ECH loss led to a chronically prolonged endoplasmic reticulum stress in the ech mutant. These results provide insights into understanding the role of TGN components in the regulation of plant immunity and stress responses.<\/jats:p>","DOI":"10.1093\/plphys\/kiac400","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T14:00:06Z","timestamp":1661522406000},"page":"558-574","source":"Crossref","is-referenced-by-count":19,"title":["The plant <i>trans<\/i>-Golgi network component ECHIDNA regulates defense, cell death, and endoplasmic reticulum stress"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-0407","authenticated-orcid":false,"given":"Lijiang","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences , Wuhan 430062, China"},{"name":"Department of Biology, University of Saskatchewan , Saskatoon, S7N 5E2, 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