{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:41:30Z","timestamp":1782157290718,"version":"3.54.5"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Organisms require micronutrients, and Arabidopsis (Arabidopsis thaliana) IRON-REGULATED TRANSPORTER1 (IRT1) is essential for iron (Fe2+) acquisition into root cells. Uptake of reactive Fe2+ exposes cells to the risk of membrane lipid peroxidation. Surprisingly little is known about how this is avoided. IRT1 activity is controlled by an intracellular variable region (IRT1vr) that acts as a regulatory protein interaction platform. Here, we describe that IRT1vr interacted with peripheral plasma membrane SEC14-Golgi dynamics (SEC14-GOLD) protein PATELLIN2 (PATL2). SEC14 proteins bind lipophilic substrates and transport or present them at the membrane. To date, no direct roles have been attributed to SEC14 proteins in Fe import. PATL2 affected root Fe acquisition responses, interacted with ROS response proteins in roots, and alleviated root lipid peroxidation. PATL2 had high affinity in vitro for the major lipophilic antioxidant vitamin E compound \u03b1-tocopherol. Molecular dynamics simulations provided insight into energetic constraints and the orientation and stability of the PATL2-ligand interaction in atomic detail. Hence, this work highlights a compelling mechanism connecting vitamin E with root metal ion transport at the plasma membrane with the participation of an IRT1-interacting and \u03b1-tocopherol-binding SEC14 protein.<\/jats:p>","DOI":"10.1093\/plphys\/kiac563","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T21:32:23Z","timestamp":1670621543000},"page":"504-526","source":"Crossref","is-referenced-by-count":18,"title":["SEC14-GOLD protein PATELLIN2 binds IRON-REGULATED TRANSPORTER1 linking root iron uptake to vitamin E"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-0272","authenticated-orcid":false,"given":"Jannik","family":"Hornbergs","sequence":"first","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0476-2160","authenticated-orcid":false,"given":"Karolin","family":"Montag","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-1923","authenticated-orcid":false,"given":"Jennifer","family":"Loschwitz","sequence":"additional","affiliation":[{"name":"Institute of Theoretical Chemistry and Computer Chemistry, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"},{"name":"Institute of Biological Information Processing (IBI-7: Structural Biochemistry) , Forschungszentrum J\u00fclich, 52425 J\u00fclich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3496-5516","authenticated-orcid":false,"given":"Inga","family":"Mohr","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-0611","authenticated-orcid":false,"given":"Gereon","family":"Poschmann","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, Proteome Research, Medical Faculty and University Hospital, Heinrich-Heine-University D\u00fcsseldorf , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Schnake","sequence":"additional","affiliation":[{"name":"Institute for Molecular Ecophysiology of Plants, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-7211","authenticated-orcid":false,"given":"Regina","family":"Gratz","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3104-6795","authenticated-orcid":false,"given":"Tzvetina","family":"Brumbarova","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-5121","authenticated-orcid":false,"given":"Monique","family":"Eutebach","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-6812","authenticated-orcid":false,"given":"Kalina","family":"Angrand","sequence":"additional","affiliation":[{"name":"Department of Biosciences-Plant Biology, Saarland University , Campus A2.4, D-66123 Saarbr\u00fccken , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fink-Straube","sequence":"additional","affiliation":[{"name":"Leibniz Institute for New Materials , D-66123 Saarbr\u00fccken , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"St\u00fchler","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, Proteome Research, Medical Faculty and University Hospital, Heinrich-Heine-University D\u00fcsseldorf , D\u00fcsseldorf 40225 , Germany"},{"name":"Molecular Proteomics Laboratory, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-5403","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Zeier","sequence":"additional","affiliation":[{"name":"Institute for Molecular Ecophysiology of Plants, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"},{"name":"Cluster of Excellence on Plant Science (CEPLAS), Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-6405","authenticated-orcid":false,"given":"Laura","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Macromolecular Chemistry, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8734-7765","authenticated-orcid":false,"given":"Birgit","family":"Strodel","sequence":"additional","affiliation":[{"name":"Institute of Theoretical Chemistry and Computer Chemistry, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"},{"name":"Institute of Biological Information Processing (IBI-7: Structural Biochemistry) , Forschungszentrum J\u00fclich, 52425 J\u00fclich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-4123","authenticated-orcid":false,"given":"Rumen","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-4532","authenticated-orcid":false,"given":"Petra","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"},{"name":"Cluster of Excellence on Plant Science (CEPLAS), Heinrich Heine University , D\u00fcsseldorf 40225 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"2023050211442835000_kiac563-B107","first-page":"9","volume-title":"Methods Mol Biol","author":"Abdallah","year":"2016"},{"key":"2023050211442835000_kiac563-B1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"2023050211442835000_kiac563-B2","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-5-research0023","article-title":"The GOLD domain, a novel protein module involved in Golgi function and secretion","volume":"3","author":"Anantharaman","year":"2002","journal-title":"Genome Biol"},{"key":"2023050211442835000_kiac563-B3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2021.09.021","article-title":"\u03b1-Tocopherol transfer protein (\u03b1-TTP)","volume":"176","author":"Arai","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2023050211442835000_kiac563-B4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-030-05315-4_9","volume-title":"Vitamin E in Human Health","author":"Atkinson","year":"2019"},{"key":"2023050211442835000_kiac563-B5","author":"Avogadro","year":"2012"},{"issue":"1","key":"2023050211442835000_kiac563-B6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jbior.2011.11.001","article-title":"Thoughts on Sec14-like nanoreactors and phosphoinositide signaling","volume":"52","author":"Bankaitis","year":"2012","journal-title":"Adv Biol Regul"},{"issue":"22","key":"2023050211442835000_kiac563-B7","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1073\/pnas.1402262111","article-title":"Polarization of IRON-REGULATED TRANSPORTER 1 (IRT1) to the plant-soil interface plays crucial role in metal homeostasis","volume":"111","author":"Barberon","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023050211442835000_kiac563-B9","first-page":"2188","article-title":"A tomato tocopherol-binding protein sheds light on intracellular \u03b1-tocopherol metabolism in plants","volume":"59","author":"Berm\u00fadez","year":"2018","journal-title":"Plant Cell Physiol"},{"issue":"7","key":"2023050211442835000_kiac563-B10","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.devcel.2021.02.008","article-title":"Maintaining the structural and functional homeostasis of the plant endoplasmic reticulum","volume":"56","author":"Brandizzi","year":"2021","journal-title":"Dev Cell"},{"issue":"1","key":"2023050211442835000_kiac563-B11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tplants.2014.07.005","article-title":"Iron nutrition, biomass production, and plant product quality","volume":"20","author":"Briat","year":"2015","journal-title":"Trends Plant Sci"},{"key":"2023050211442835000_kiac563-B12","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3389\/fpls.2016.01456","article-title":"Differential gene expression and protein phosphorylation as factors regulating the state of the Arabidopsis SNX1 protein complexes in response to environmental stimuli","volume":"7","author":"Brumbarova","year":"2016","journal-title":"Front Plant Sci"},{"issue":"21","key":"2023050211442835000_kiac563-B13","doi-asserted-by":"crossref","first-page":"e1999","DOI":"10.21769\/BioProtoc.1999","article-title":"Hydrogen peroxide measurement in Arabidopsis root tissue using amplex red","volume":"6","author":"Brumbarova","year":"2016","journal-title":"Bio Protoc"},{"issue":"6825","key":"2023050211442835000_kiac563-B14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/35065626","article-title":"The S-locus receptor kinase is inhibited by thioredoxins and activated by pollen coat proteins","volume":"410","author":"Cabrillac","year":"2001","journal-title":"Nature"},{"issue":"3","key":"2023050211442835000_kiac563-B15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-313X.2011.04510.x","article-title":"A fast brassinolide-regulated response pathway in the plasma membrane of Arabidopsis thaliana","volume":"66","author":"Caesar","year":"2011","journal-title":"Plant J"},{"issue":"4","key":"2023050211442835000_kiac563-B16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1768-322X.2004.tb01415.x","article-title":"P24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities","volume":"96","author":"Carney","year":"2004","journal-title":"Biol Cell"},{"key":"2023050211442835000_kiac563-B17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.plantsci.2011.09.009","article-title":"Comparative phosphoproteomic analysis of microsomal fractions of Arabidopsis thaliana and Oryza sativa subjected to high salinity","volume":"185-186","author":"Chang","year":"2012","journal-title":"Plant Sci"},{"issue":"21","key":"2023050211442835000_kiac563-B18","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1093\/jxb\/ery278","article-title":"Atcam4 interacts with a Sec14-like protein, PATL1, to regulate freezing tolerance in Arabidopsis in a CBF-independent manner","volume":"69","author":"Chu","year":"2018","journal-title":"J Exp Bot"},{"issue":"6","key":"2023050211442835000_kiac563-B19","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1105\/tpc.001263","article-title":"Expression of the IRT1 metal transporter is controlled by metals at the levels of transcript and protein accumulation","volume":"14","author":"Connolly","year":"2002","journal-title":"Plant Cell"},{"issue":"2","key":"2023050211442835000_kiac563-B20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1104\/pp.103.027979","article-title":"A gateway cloning vector set for high-throughput functional analysis of genes in planta","volume":"133","author":"Curtis","year":"2003","journal-title":"Plant Physiol"},{"key":"2023050211442835000_kiac563-B21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pbi.2017.09.007","article-title":"The regulation of cell polarity by lipid transfer proteins of the SEC14 family","volume":"40","author":"de Campos","year":"2017","journal-title":"Curr Opin Plant Biol"},{"issue":"2","key":"2023050211442835000_kiac563-B22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/mp\/sst009","article-title":"The calcineurin B-like calcium sensors CBL1 and CBL9 together with their interacting protein kinase CIPK26 regulate the Arabidopsis NADPH oxidase RBOHF","volume":"6","author":"Drerup","year":"2013","journal-title":"Mol Plant"},{"issue":"6","key":"2023050211442835000_kiac563-B23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.molcel.2018.02.009","article-title":"Metal sensing by the IRT1 transporter-receptor orchestrates its own degradation and plant metal nutrition","volume":"69","author":"Dubeaux","year":"2018","journal-title":"Mol Cell"},{"issue":"11","key":"2023050211442835000_kiac563-B24","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1073\/pnas.93.11.5624","article-title":"A novel iron-regulated metal transporter from plants identified by functional expression in yeast","volume":"93","author":"Eide","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2023050211442835000_kiac563-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1099-1352(199601)9:1<1::AID-JMR241>3.0.CO;2-6","article-title":"Automated docking of flexible ligands: applications of AutoDock","volume":"9","author":"Goodsell","year":"1996","journal-title":"J Mol Recognit"},{"issue":"1","key":"2023050211442835000_kiac563-B26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/nph.16168","article-title":"Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FIT","volume":"225","author":"Gratz","year":"2019","journal-title":"New Phytol"},{"issue":"5","key":"2023050211442835000_kiac563-B27","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.devcel.2019.01.006","article-title":"CIPK11-dependent phosphorylation modulates FIT activity to promote Arabidopsis iron acquisition in response to calcium signaling","volume":"48","author":"Gratz","year":"2019","journal-title":"Dev Cell"},{"key":"2023050211442835000_kiac563-B28","doi-asserted-by":"crossref","first-page":"102048","DOI":"10.1016\/j.pbi.2021.102048","article-title":"Fe acquisition at the crossroad of calcium and reactive oxygen species signaling","volume":"63","author":"Gratz","year":"2021","journal-title":"Curr Opin Plant Biol"},{"issue":"5","key":"2023050211442835000_kiac563-B29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2144\/000113941","article-title":"A 2in1 cloning system enables ratiometric bimolecular fluorescence complementation (rBiFC)","volume":"53","author":"Grefen","year":"2012","journal-title":"Biotechniques"},{"issue":"2","key":"2023050211442835000_kiac563-B30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1021\/acs.jproteome.7b00684","article-title":"Mining the secretome of C2C12 muscle cells: data dependent experimental approach to analyze protein secretion using label-free quantification and peptide based analysis","volume":"17","author":"Grube","year":"2018","journal-title":"J Proteome Res"},{"issue":"1-2","key":"2023050211442835000_kiac563-B31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0005-2736(00)00138-3","article-title":"The ZIP family of metal transporters","volume":"1465","author":"Guerinot","year":"2000","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"2023050211442835000_kiac563-B32","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1111\/nph.15543","article-title":"Fine-tuning of RBOHF activity is achieved by differential phosphorylation and Ca(2+) binding","volume":"221","author":"Han","year":"2019","journal-title":"New Phytol"},{"issue":"1","key":"2023050211442835000_kiac563-B33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J Cheminform"},{"issue":"12","key":"2023050211442835000_kiac563-B34","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1105\/tpc.105.037036","article-title":"Vitamin E protects against photoinhibition and photooxidative stress in Arabidopsis thaliana","volume":"17","author":"Havaux","year":"2005","journal-title":"Plant Cell"},{"issue":"4\/5","key":"2023050211442835000_kiac563-B35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1023\/A:1019942200164","article-title":"Knock-out of Arabidopsis metal transporter gene IRT1 results in iron deficiency accompanied by cell differentiation defects","volume":"50","author":"Henriques","year":"2002","journal-title":"Plant Mol. Biol"},{"issue":"1","key":"2023050211442835000_kiac563-B36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1477-5956-7-42","article-title":"Functional phosphoproteomic profiling of phosphorylation sites in membrane fractions of salt-stressed Arabidopsis thaliana","volume":"7","author":"Hsu","year":"2009","journal-title":"Proteome Sci"},{"issue":"20","key":"2023050211442835000_kiac563-B37","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1111\/febs.15658","article-title":"Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer","volume":"288","author":"Hu","year":"2021","journal-title":"FEBS J"},{"issue":"14","key":"2023050211442835000_kiac563-B38","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1091\/mbc.E16-04-0221","article-title":"Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins","volume":"27","author":"Huang","year":"2016","journal-title":"Mol Biol Cell"},{"issue":"3","key":"2023050211442835000_kiac563-B39","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1105\/tpc.113.116244","article-title":"SORTING NEXIN1 is required for modulating the trafficking and stability of the Arabidopsis IRON-REGULATED TRANSPORTER1","volume":"26","author":"Ivanov","year":"2014","journal-title":"Plant Cell"},{"issue":"7","key":"2023050211442835000_kiac563-B40","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1105\/tpc.108.063479","article-title":"Endocytosis and endosomal regulation of the S-receptor kinase during the self-incompatibility response in Brassica oleracea","volume":"21","author":"Ivanov","year":"2009","journal-title":"Plant Cell"},{"issue":"1","key":"2023050211442835000_kiac563-B41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/boc.202000118","article-title":"Endocytosis in plants: peculiarities and roles in the regulated trafficking of plant metal transporters","volume":"113","author":"Ivanov","year":"2021","journal-title":"Biol Cell"},{"key":"2023050211442835000_kiac563-B42","doi-asserted-by":"crossref","first-page":"e57264","DOI":"10.7554\/eLife.57264","article-title":"How to measure and evaluate binding affinities","volume":"9","author":"Jarmoskaite","year":"2020","journal-title":"eLife"},{"issue":"13","key":"2023050211442835000_kiac563-B43","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1002\/j.1460-2075.1987.tb02730.x","article-title":"GUS Fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants","volume":"6","author":"Jefferson","year":"1987","journal-title":"EMBO J"},{"issue":"9","key":"2023050211442835000_kiac563-B44","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2023050211442835000_kiac563-B108","author":"Kanwar","year":"2021"},{"issue":"4","key":"2023050211442835000_kiac563-B45","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/pcp\/pcab018","article-title":"Comparative transcriptomics of lowland rice varieties leads to novel candidate genes for adaptive iron excess tolerance","volume":"62","author":"Kar","year":"2021","journal-title":"Plant Cell Physiol"},{"issue":"3","key":"2023050211442835000_kiac563-B46","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1104\/pp.19.00163","article-title":"Calcium-promoted interaction between the C2-domain protein EHB1 and metal transporter IRT1 inhibits Arabidopsis iron acquisition","volume":"180","author":"Khan","year":"2019","journal-title":"Plant Physiol"},{"issue":"6136","key":"2023050211442835000_kiac563-B47","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.1233508","article-title":"Impaired \u03b1-TTP-PIPs interaction underlies familial vitamin E deficiency","volume":"340","author":"Kono","year":"2013","journal-title":"Science"},{"issue":"1","key":"2023050211442835000_kiac563-B48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1026438615520","article-title":"The IRT1 protein from Arabidopsis thaliana is a metal transporter with a broad substrate range","volume":"40","author":"Korshunova","year":"1999","journal-title":"Plant Mol Biol"},{"issue":"3","key":"2023050211442835000_kiac563-B49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.embor.7400919","article-title":"Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling","volume":"8","author":"Krauss","year":"2007","journal-title":"EMBO Rep"},{"issue":"1","key":"2023050211442835000_kiac563-B50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1104\/pp.112.193987","article-title":"Quantitative phosphoproteome profiling of iron-deficient Arabidopsis roots","volume":"159","author":"Lan","year":"2012","journal-title":"Plant Physiol"},{"issue":"11","key":"2023050211442835000_kiac563-B51","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.febslet.2009.03.019","article-title":"The structural basis of allosteric regulation in proteins","volume":"583","author":"Laskowski","year":"2009","journal-title":"FEBS Lett"},{"key":"2023050211442835000_kiac563-B52","first-page":"43","volume-title":"Redox Homeostasis in Plants, From Signalling to Stress Tolerance","author":"Le","year":"2019"},{"issue":"1","key":"2023050211442835000_kiac563-B53","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1104\/pp.15.01589","article-title":"Zinc finger of Arabidopsis thaliana12 (ZAT12) interacts with FER-like iron deficiency-induced transcription factor (FIT) linking iron deficiency and oxidative stress responses","volume":"170","author":"Le","year":"2016","journal-title":"Plant Physiol"},{"issue":"4","key":"2023050211442835000_kiac563-B54","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/tpj.15593","article-title":"Spatial regulation of RBOHD via AtECA4-mediated recycling and clathrin-mediated endocytosis contributes to ROS accumulation during salt stress response but not flg22-induced immune response","volume":"109","author":"Lee","year":"2021","journal-title":"Plant J"},{"issue":"4","key":"2023050211442835000_kiac563-B55","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.molp.2020.01.006","article-title":"bHLH121 functions as a direct link that facilitates the activation of FIT by bHLH IVc transcription factors for maintaining Fe homeostasis in Arabidopsis","volume":"13","author":"Lei","year":"2020","journal-title":"Mol Plant"},{"key":"2023050211442835000_kiac563-B56","author":"Lindahl","year":"2021"},{"issue":"1","key":"2023050211442835000_kiac563-B57","doi-asserted-by":"crossref","first-page":"e53787","DOI":"10.1371\/journal.pone.0053787","article-title":"pAUL: a gateway-based vector system for adaptive expression and flexible tagging of proteins in Arabidopsis","volume":"8","author":"Lyska","year":"2013","journal-title":"PLoS One"},{"key":"2023050211442835000_kiac563-B109","author":"Mart\u00edn-Barranco","year":"2020"},{"issue":"4","key":"2023050211442835000_kiac563-B58","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1104\/pp.18.01065","article-title":"Osmotic stress activates two reactive oxygen species pathways with distinct effects on protein nanodomains and diffusion","volume":"179","author":"Martini\u00e8re","year":"2019","journal-title":"Plant Physiol"},{"issue":"29","key":"2023050211442835000_kiac563-B59","doi-asserted-by":"crossref","first-page":"12126","DOI":"10.1073\/pnas.1306331110","article-title":"Transorganellar complementation redefines the biochemical continuity of endoplasmic reticulum and chloroplasts","volume":"110","author":"Mehrshahi","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2023050211442835000_kiac563-B60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/antiox7010002","article-title":"Vitamin E biosynthesis and its regulation in plants","volume":"7","author":"M\u00e8ne-Saffran\u00e9","year":"2018","journal-title":"Antioxidants"},{"issue":"D1","key":"2023050211442835000_kiac563-B61","doi-asserted-by":"crossref","first-page":"D394","DOI":"10.1093\/nar\/gkaa1106","article-title":"PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API","volume":"49","author":"Mi","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2023050211442835000_kiac563-B62","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s11103-020-01067-y","article-title":"Phylogenetic analysis of plant multi-domain SEC14-like phosphatidylinositol transfer proteins and structure\u2013function properties of PATELLIN2","volume":"104","author":"Montag","year":"2020","journal-title":"Plant Mol Biol"},{"issue":"1","key":"2023050211442835000_kiac563-B63","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1038\/s41598-017-11171-7","article-title":"Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein","volume":"7","author":"Naranjo Arcos","year":"2017","journal-title":"Sci Rep"},{"key":"2023050211442835000_kiac563-B64","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1016\/j.bmc.2006.01.053","article-title":"Preparation of fluorescent tocopherols for use in protein binding and localization with the \u03b1-tocopherol transfer protein","volume":"14","author":"Nava","year":"2006","journal-title":"Bioorgan Med Chem"},{"issue":"1","key":"2023050211442835000_kiac563-B65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-arplant-081519-035910","article-title":"Functions of anionic lipids in plants","volume":"71","author":"Noack","year":"2020","journal-title":"Annu Rev Plant Biol"},{"key":"2023050211442835000_kiac563-B66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2017.07.013","article-title":"ROS-related redox regulation and signaling in plants","volume":"80","author":"Noctor","year":"2018","journal-title":"Sem Cell Dev Biol"},{"issue":"1","key":"2023050211442835000_kiac563-B67","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0092-8674(80)90128-2","article-title":"Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway","volume":"21","author":"Novick","year":"1980","journal-title":"Cell"},{"issue":"6","key":"2023050211442835000_kiac563-B68","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.3390\/ijms22062950","article-title":"Antioxidant and signaling role of plastid-derived isoprenoid quinones and chromanols","volume":"22","author":"Nowicka","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2023050211442835000_kiac563-B69","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bbamem.2018.12.003","article-title":"In vitro lipid transfer assays of phosphatidylinositol transfer proteins provide insight into the in vivo mechanism of ligand transfer","volume":"1861","author":"Panagabko","year":"2019","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"2","key":"2023050211442835000_kiac563-B70","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1104\/pp.104.045369","article-title":"Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides","volume":"136","author":"Peterman","year":"2004","journal-title":"Plant Physiol"},{"key":"2023050211442835000_kiac563-B71","author":"PyMol","year":"2015"},{"issue":"3","key":"2023050211442835000_kiac563-B72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1365-313X.2008.03698.x","article-title":"Ferritins control interaction between iron homeostasis and oxidative stress in Arabidopsis","volume":"57","author":"Ravet","year":"2009","journal-title":"Plant J"},{"issue":"3","key":"2023050211442835000_kiac563-B73","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molp.2014.11.014","article-title":"Iron- and ferritin-dependent reactive oxygen species distribution: impact on Arabidopsis root system architecture","volume":"8","author":"Reyt","year":"2015","journal-title":"Mol Plant"},{"issue":"6721","key":"2023050211442835000_kiac563-B74","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/17800","article-title":"A ferric-chelate reductase for iron uptake from soils","volume":"397","author":"Robinson","year":"1999","journal-title":"Nature"},{"issue":"4","key":"2023050211442835000_kiac563-B75","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat Protoc"},{"issue":"1","key":"2023050211442835000_kiac563-B76","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1104\/pp.16.01253","article-title":"Extracellular vesicles isolated from the leaf apoplast carry stress-response proteins","volume":"173","author":"Rutter","year":"2017","journal-title":"Plant Physiol"},{"issue":"6","key":"2023050211442835000_kiac563-B77","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.bbalip.2007.02.010","article-title":"The lipid-binding SEC14 domain","volume":"1771","author":"Saito","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"2023050211442835000_kiac563-B78","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/ci500209e","article-title":"Autodock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins","volume":"54","author":"Santos-Martins","year":"2014","journal-title":"J Chem Inf Model"},{"issue":"6","key":"2023050211442835000_kiac563-B79","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1105\/tpc.021360","article-title":"Vitamin E is essential for seed longevity and for preventing lipid peroxidation during germination","volume":"16","author":"Sattler","year":"2004","journal-title":"Plant Cell"},{"issue":"6","key":"2023050211442835000_kiac563-B80","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1091\/mbc.e10-11-0903","article-title":"Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution","volume":"22","author":"Schaaf","year":"2011","journal-title":"Mol Biol Cell"},{"issue":"2","key":"2023050211442835000_kiac563-B81","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molcel.2007.11.026","article-title":"Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily","volume":"29","author":"Schaaf","year":"2008","journal-title":"Mol Cell"},{"issue":"1-2","key":"2023050211442835000_kiac563-B82","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11103-006-9015-0","article-title":"Transmembrane topology of FRO2, a ferric chelate reductase from Arabidopsis thaliana","volume":"62","author":"Schagerl\u00f6f","year":"2006","journal-title":"Plant Mol Biol"},{"issue":"6666","key":"2023050211442835000_kiac563-B83","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/35179","article-title":"Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol-transfer protein","volume":"391","author":"Sha","year":"1998","journal-title":"Nature"},{"issue":"8","key":"2023050211442835000_kiac563-B84","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1105\/tpc.113.115212","article-title":"IRT1 degradation factor1, a ring E3 ubiquitin ligase, regulates the degradation of iron-regulated transporter1 in Arabidopsis","volume":"25","author":"Shin","year":"2013","journal-title":"Plant Cell"},{"issue":"9","key":"2023050211442835000_kiac563-B85","doi-asserted-by":"crossref","first-page":"e44843","DOI":"10.1371\/journal.pone.0044843","article-title":"Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway","volume":"7","author":"Sivitz","year":"2012","journal-title":"PLoS One"},{"key":"2023050211442835000_kiac563-B86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chemphyslip.2014.02.002","article-title":"Cellular and molecular interactions of phosphoinositides and peripheral proteins","volume":"182","author":"Stahelin","year":"2014","journal-title":"Chem Phys Lipids"},{"issue":"3","key":"2023050211442835000_kiac563-B87","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1104\/pp.19.00618","article-title":"A role for tocopherol biosynthesis in Arabidopsis basal immunity to bacterial infection","volume":"181","author":"Stahl","year":"2019","journal-title":"Plant Physiol"},{"key":"2023050211442835000_kiac563-B88","author":"Global Nutrition Report","year":"2021"},{"issue":"1","key":"2023050211442835000_kiac563-B89","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bpj.2018.11.3131","article-title":"Biophysical parameters of the Sec14 phospholipid exchange cycle","volume":"116","author":"Sugiura","year":"2019","journal-title":"Biophys J"},{"issue":"8","key":"2023050211442835000_kiac563-B90","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1093\/pcp\/pcw098","article-title":"Identification of phosphoinositide-binding protein PATELLIN2 as a substrate of Arabidopsis MPK4 MAP kinase during septum formation in cytokinesis","volume":"57","author":"Suzuki","year":"2016","journal-title":"Plant Cell Physiol"},{"key":"2023050211442835000_kiac563-B91","volume-title":"Vitamin E in Human Health. Nutrition and Health","author":"Sylvester","year":"2019"},{"issue":"2","key":"2023050211442835000_kiac563-B92","doi-asserted-by":"crossref","first-page":"jcs204198","DOI":"10.1242\/jcs.204198","article-title":"PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in Arabidopsis thaliana","volume":"131","author":"Tejos","year":"2018","journal-title":"J Cell Sci"},{"key":"2023050211442835000_kiac563-B93","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.plantsci.2016.01.010","article-title":"CIPK23 Is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity","volume":"246","author":"Tian","year":"2016","journal-title":"Plant Sci"},{"key":"2023050211442835000_kiac563-B94","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"issue":"6","key":"2023050211442835000_kiac563-B95","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1105\/tpc.001388","article-title":"IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth","volume":"14","author":"Vert","year":"2002","journal-title":"Plant Cell"},{"issue":"6","key":"2023050211442835000_kiac563-B96","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/jxb\/eraa522","article-title":"Reactive oxygen species coordinate the transcriptional responses to iron availability in Arabidopsis","volume":"72","author":"von der Mark","year":"2021","journal-title":"J Exp Bot"},{"issue":"7","key":"2023050211442835000_kiac563-B97","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tibs.2017.05.001","article-title":"Advances on the transfer of lipids by lipid transfer proteins","volume":"42","author":"Wong","year":"2017","journal-title":"Trends Biochem Sci"},{"issue":"12","key":"2023050211442835000_kiac563-B98","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/jipb.12578","article-title":"Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit","volume":"59","author":"Wu","year":"2017","journal-title":"J Integr Plant Biol"},{"issue":"1","key":"2023050211442835000_kiac563-B99","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat Methods"},{"issue":"3","key":"2023050211442835000_kiac563-B100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/cr.2008.26","article-title":"FIT Interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis","volume":"18","author":"Yuan","year":"2008","journal-title":"Cell Res"},{"key":"2023050211442835000_kiac563-B101","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.817","article-title":"Analysis of malondialdehyde, chlorophyll proline, soluble sugar, and glutathione content in Arabidopsis seedling","volume":"3","author":"Zhang","year":"2013","journal-title":"Bio Protoc"},{"issue":"3","key":"2023050211442835000_kiac563-B102","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1105\/tpc.114.132704","article-title":"The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis","volume":"27","author":"Zhang","year":"2015","journal-title":"Plant Cell"},{"issue":"4","key":"2023050211442835000_kiac563-B103","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.jmb.2010.11.028","article-title":"The contribution of surface residues to membrane binding and ligand transfer by the \u03b1-tocopherol transfer protein (\u03b1-TTP)","volume":"405","author":"Zhang","year":"2011","journal-title":"J Mol Biol"},{"issue":"6","key":"2023050211442835000_kiac563-B104","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1073\/pnas.93.6.2454","article-title":"The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation","volume":"93","author":"Zhao","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2023050211442835000_kiac563-B105","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/pcp\/pcy081","article-title":"Patellin1 negatively modulates salt tolerance by regulating PM Na+\/H+ antiport activity and cellular redox homeostasis in Arabidopsis","volume":"59","author":"Zhou","year":"2018","journal-title":"Plant Cell Physiol"},{"key":"2023050211442835000_kiac563-B106","volume-title":"Vitamin E in Human Health. Nutrition and Health","author":"Zingg","year":"2019"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/plphys\/advance-article-pdf\/doi\/10.1093\/plphys\/kiac563\/49118037\/kiac563.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/192\/1\/504\/50168393\/kiac563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/192\/1\/504\/50168393\/kiac563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T04:43:40Z","timestamp":1728535420000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/192\/1\/504\/6885538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":108,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12,9]]},"published-print":{"date-parts":[[2023,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/plphys\/kiac563","relation":{},"ISSN":["0032-0889","1532-2548"],"issn-type":[{"value":"0032-0889","type":"print"},{"value":"1532-2548","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,12,9]]}}}