{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:21:01Z","timestamp":1790875261358,"version":"4.1.0"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["31870170"],"award-info":[{"award-number":["31870170"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["31701168"],"award-info":[{"award-number":["31701168"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xu Chen"},{"DOI":"10.13039\/501100008766","name":"Fujian Agriculture and Forestry University","doi-asserted-by":"publisher","award":["xjq201921"],"award-info":[{"award-number":["xjq201921"]}],"id":[{"id":"10.13039\/501100008766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017601","name":"Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University","doi-asserted-by":"publisher","award":["324-1122yb082"],"award-info":[{"award-number":["324-1122yb082"]}],"id":[{"id":"10.13039\/501100017601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The primary cell wall is a fundamental plant constituent that is flexible but sufficiently rigid to support the plant cell shape. Although many studies have demonstrated that reactive oxygen species (ROS) serve as important signaling messengers to modify the cell wall structure and affect cellular growth, the regulatory mechanism underlying the spatial-temporal regulation of ROS activity for cell wall maintenance remains largely unclear. Here, we demonstrate the role of the Arabidopsis (Arabidopsis thaliana) multicopper oxidase-like protein skewed 5 (SKU5) and its homolog SKU5-similar 1 (SKS1) in root cell wall formation through modulating ROS homeostasis. Loss of SKU5 and SKS1 function resulted in aberrant division planes, protruding cell walls, ectopic deposition of iron, and reduced nicotinamide adeninedinucleotide phosphate (NADPH) oxidase-dependent ROS overproduction in the root epidermis\u2013cortex and cortex\u2013endodermis junctions. A decrease in ROS level or inhibition of NADPH oxidase activity rescued the cell wall defects of sku5 sks1 double mutants. SKU5 and SKS1 proteins were activated by iron treatment, and iron over-accumulated in the walls between the root epidermis and cortex cell layers of sku5 sks1. The glycosylphosphatidylinositol-anchored motif was crucial for membrane association and functionality of SKU5 and SKS1. Overall, our results identified SKU5 and SKS1 as regulators of ROS at the cell surface for regulation of cell wall structure and root cell growth.<\/jats:p>","DOI":"10.1093\/plphys\/kiad207","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:59:26Z","timestamp":1680523166000},"page":"2243-2260","source":"Crossref","is-referenced-by-count":32,"title":["Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-4148","authenticated-orcid":false,"given":"Chaofan","family":"Chen","sequence":"first","affiliation":[{"name":"College of Life Science and Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"},{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-4762","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science and Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"},{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-5629","authenticated-orcid":false,"given":"Jianfa","family":"Cai","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-0740","authenticated-orcid":false,"given":"Yuting","family":"Qiu","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-2079","authenticated-orcid":false,"given":"Lihong","family":"Li","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3743-9546","authenticated-orcid":false,"given":"Chengxu","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences , Beijing 100101 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3440-2772","authenticated-orcid":false,"given":"Yiqun","family":"Gao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences , Shanghai 200032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-1674","authenticated-orcid":false,"given":"Meiyu","family":"Ke","sequence":"additional","affiliation":[{"name":"College of Life Science and Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"},{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2696-7052","authenticated-orcid":false,"given":"Shengwei","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life Science and Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"},{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-118X","authenticated-orcid":false,"given":"Chuan","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Life Science and Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-9178","authenticated-orcid":false,"given":"Jiaomei","family":"Chen","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-9217","authenticated-orcid":false,"given":"Tongda","family":"Xu","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-7596","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Friml","sequence":"additional","affiliation":[{"name":"Faculty of Cell Biology, Institute of Science and Technology Austria (IST Austria) , Klosterneuburg 3400 , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-0263","authenticated-orcid":false,"given":"Junqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology , Shenzhen, Guangdong 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-5436","authenticated-orcid":false,"given":"Ruixi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology , Shenzhen, Guangdong 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-4800","authenticated-orcid":false,"given":"Daiyin","family":"Chao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences , Shanghai 200032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-7263","authenticated-orcid":false,"given":"Baocai","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences , Beijing 100101 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-083X","authenticated-orcid":false,"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-0634","authenticated-orcid":false,"given":"Zhen","family":"Gao","sequence":"additional","affiliation":[{"name":"FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"issue":"19","key":"2023070301171473800_kiad207-B1","doi-asserted-by":"crossref","first-page":"19002","DOI":"10.1007\/s11356-016-7309-6","article-title":"Catalase and ascorbate peroxidase\u2014representative H2O2-detoxifying heme enzymes in plants","volume":"23","author":"Anjum","year":"2016","journal-title":"Environ Sci Pollut Res 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