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To elucidate the mechanisms underlying developmentally controlled thermogenesis and thermoregulation in skunk cabbage, we conducted a comprehensive transcriptome and metabolome analysis across 3 developmental stages of spadix development. Our RNA-seq analysis revealed distinct groups of expressed genes, with selenium-binding protein 1\/methanethiol oxidase (SBP1\/MTO) exhibiting the highest levels in thermogenic florets. Notably, the expression of alternative oxidase (AOX) was consistently high from the prethermogenic stage through the thermogenic stage in the florets. Metabolome analysis showed that alterations in nucleotide levels correspond with the developmentally controlled and tissue-specific thermogenesis of skunk cabbage, evident by a substantial increase in AMP levels in thermogenic florets. Our study also reveals that hydrogen sulfide, a product of SBP1\/MTO, inhibits cytochrome c oxidase (COX)-mediated mitochondrial respiration, while AOX-mediated respiration remains relatively unaffected. Specifically, at lower temperatures, the inhibitory effect of hydrogen sulfide on COX-mediated respiration increases, promoting a shift toward the dominance of AOX-mediated respiration. Finally, despite the differential regulation of genes and metabolites throughout spadix development, we observed a convergence of gene expression and metabolite accumulation patterns during thermogenesis. This synchrony may play a key role in developmentally regulated thermogenesis. Moreover, such convergence during the thermogenic stage in the spadix may provide a solid molecular basis for thermoregulation in skunk cabbage.<\/jats:p>","DOI":"10.1093\/plphys\/kiae059","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T06:57:10Z","timestamp":1707202630000},"page":"1561-1585","source":"Crossref","is-referenced-by-count":10,"title":["Gene expression and metabolite levels converge in the thermogenic spadix of skunk cabbage"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9313-6318","authenticated-orcid":false,"given":"Haruka","family":"Tanimoto","sequence":"first","affiliation":[{"name":"United Graduate School of Agricultural Science, Iwate University , Morioka, Iwate 020-8550 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9190-3199","authenticated-orcid":false,"given":"Yui","family":"Umekawa","sequence":"additional","affiliation":[{"name":"Department of Planning and General Affairs, Akita Research Institute of Food and Brewing , Araya-machi, Akita 010-1623 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-5353","authenticated-orcid":false,"given":"Hideyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Agriculture, School of Agriculture, Tokai University , Kumamoto 862-8652 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6511-9836","authenticated-orcid":false,"given":"Kota","family":"Goto","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Iwate University , Morioka, Iwate 020-8550 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-3462","authenticated-orcid":false,"given":"Kikukatsu","family":"Ito","sequence":"additional","affiliation":[{"name":"United Graduate School of Agricultural Science, Iwate University , Morioka, Iwate 020-8550 , Japan"},{"name":"Faculty of Agriculture, Iwate University , Morioka, Iwate 020-8550 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"issue":"2","key":"2024053117411945300_kiae059-B1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1095-8339.2003.00139.x","article-title":"Pollination ecology of Arum italicum (Araceae)","volume":"141","author":"Albre","year":"2003","journal-title":"Bot J Linn Soc"},{"issue":"3","key":"2024053117411945300_kiae059-B2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00425-010-1207-9","article-title":"Arabidopsis sucrose 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