{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:27:44Z","timestamp":1789090064952,"version":"build-2803163510"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372813"],"award-info":[{"award-number":["32372813"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030099"],"award-info":[{"award-number":["32030099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["tsqn202312287"],"award-info":[{"award-number":["tsqn202312287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012492","name":"Youth Innovation Promotion Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005542","name":"CAS","doi-asserted-by":"publisher","award":["2020315"],"award-info":[{"award-number":["2020315"]}],"id":[{"id":"10.13039\/100005542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["ISSASIP2208"],"award-info":[{"award-number":["ISSASIP2208"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Improving nitrogen-use efficiency is an important path toward enhancing crop yield and alleviating the environmental impacts of fertilizer use. Ammonium (NH4+) is the energetically preferred inorganic N source for plants. The interaction of NH4+ with other nutrients is a chief determinant of ammonium-use efficiency (AUE) and of the tipping point toward ammonium toxicity, but these interactions have remained ill-defined. Here, we report that iron (Fe) accumulation is a critical factor determining AUE and have identified a substance that can enhance AUE by manipulating Fe availability. Fe accumulation under NH4+ nutrition induces NH4+ efflux in the root system, reducing both growth and AUE in Arabidopsis (Arabidopsis thaliana). Low external availability of Fe and a low plant Fe status substantially enhance protein N-glycosylation through a Vitamin C1-independent pathway, thereby reducing NH4+ efflux to increase AUE during the vegetative stage in Arabidopsis under elevated NH4+ supply. We confirm the validity of the iron\u2013ammonium interaction in the important crop species lettuce (Lactuca sativa). We further show that dolomite can act as an effective substrate to subdue Fe accumulation under NH4+ nutrition by reducing the expression of Low Phosphate Root 2 and acidification of the rhizosphere. Our findings present a strategy to improve AUE and reveal the underlying molecular\u2013physiological mechanism.<\/jats:p>","DOI":"10.1093\/plphys\/kiae103","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T20:18:01Z","timestamp":1708805881000},"page":"1712-1727","source":"Crossref","is-referenced-by-count":18,"title":["Plant iron status regulates ammonium-use efficiency through protein N-glycosylation"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-6722","authenticated-orcid":false,"given":"Guangjie","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Sciences , Jinan 250100 , China"},{"name":"State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , Nanjing 210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3175-8642","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Sciences , Jinan 250100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2702-2226","authenticated-orcid":false,"given":"Jinlin","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , Nanjing 210008 , China"},{"name":"College of Advanced Agricultural Sciences, University of the Chinese Academy of Sciences , No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8083-8726","authenticated-orcid":false,"given":"Zhaoyue","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , Nanjing 210008 , China"},{"name":"College of Advanced Agricultural Sciences, University of the Chinese Academy of Sciences , No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-0998","authenticated-orcid":false,"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , Nanjing 210008 , China"},{"name":"College of Advanced Agricultural Sciences, University of the Chinese Academy of Sciences , No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-0029","authenticated-orcid":false,"given":"Herbert J","family":"Kronzucker","sequence":"additional","affiliation":[{"name":"School of BioSciences, The University of Melbourne , Parkville, VIC 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-0704","authenticated-orcid":false,"given":"Weiming","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences , Nanjing 210008 , China"},{"name":"College of Advanced Agricultural Sciences, University of the Chinese Academy of Sciences , No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049 , China"},{"name":"International Research Centre for Environmental Membrane Biology, Foshan University , Foshan 528000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"issue":"2","key":"2024053117430815400_kiae103-B1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1438-8677.2007.00022.x","article-title":"The proton pump interactor (Ppi) gene family of Arabidopsis thaliana: expression pattern of Ppi1 and characterisation of knockout mutants for Ppi1 and 2","volume":"10","author":"Anzi","year":"2008","journal-title":"Plant Biol"},{"issue":"1","key":"2024053117430815400_kiae103-B2","first-page":"23","article-title":"Optimization of ammonium acquisition and metabolism by potassium in rice (Oryza sativa L. cv. 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