{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:37:48Z","timestamp":1773823068176,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071921"],"award-info":[{"award-number":["32071921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Scholars Project","award":["ts201712024"],"award-info":[{"award-number":["ts201712024"]}]},{"name":"Taishan Scholars Project","award":["dxkt201707"],"award-info":[{"award-number":["dxkt201707"]}]},{"name":"State Key Laboratory of Crop Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Maize (Zea mays) smut is a common biotrophic fungal disease caused by Ustilago maydis and leads to low maize yield. Maize resistance to U. maydis is a quantitative trait. However, the molecular mechanism underlying the resistance of maize to U. maydis is poorly understood. Here, we reported that a maize mutant caused by a single gene mutation exhibited defects in both fungal resistance and plant development. maize mutant highly susceptible to U. maydis (mmsu) with a dwarf phenotype forms tumors in the ear. A map-based cloning and allelism test demonstrated that 1 gene encoding a putative arogenate dehydratase\/prephenate dehydratase (ADT\/PDT) is responsible for the phenotypes of the mmsu and was designated as ZmADT2. Combined transcriptomic and metabolomic analyses revealed that mmsu had substantial differences in multiple metabolic pathways in response to U. maydis infection compared with the wild type. Disruption of ZmADT2 caused damage to the chloroplast ultrastructure and function, metabolic flux redirection, and reduced the amounts of salicylic acid (SA) and lignin, leading to susceptibility to U. maydis and dwarf phenotype. These results suggested that ZmADT2 is required for maintaining metabolic flux, as well as resistance to U. maydis and plant development in maize. Meanwhile, our findings provided insights into the maize response mechanism to U. maydis infection.<\/jats:p>","DOI":"10.1093\/plphys\/kiae115","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T03:37:55Z","timestamp":1709437075000},"page":"1642-1659","source":"Crossref","is-referenced-by-count":15,"title":["Maize requires <i>arogenate dehydratase 2<\/i> for resistance to <i>Ustilago maydis<\/i> and plant development"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8940-6694","authenticated-orcid":false,"given":"Ru Chang","family":"Ren","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-003X","authenticated-orcid":false,"given":"Ling Guang","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8981-6790","authenticated-orcid":false,"given":"Guang Ming","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1984-6417","authenticated-orcid":false,"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8369-9975","authenticated-orcid":false,"given":"Jia Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-6992","authenticated-orcid":false,"given":"Cuimei","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, National Centre for Plant Gene Research (Beijing) , Beijing 100101 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1677-8776","authenticated-orcid":false,"given":"Jinfang","family":"Chu","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, National Centre for Plant Gene Research (Beijing) , Beijing 100101 , China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-5992","authenticated-orcid":false,"given":"Xin Hua","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-5206","authenticated-orcid":false,"given":"Xian Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University , Taian, Shandong 271018 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-2038","authenticated-orcid":false,"given":"Guan Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University , Qingdao, Shandong 266237 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-6542","authenticated-orcid":false,"given":"Xiang Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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