{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:16:59Z","timestamp":1781036219149,"version":"3.54.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA24030303"],"award-info":[{"award-number":["XDA24030303"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["ZDRW-ZS-2019-2-02"],"award-info":[{"award-number":["ZDRW-ZS-2019-2-02"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Development Plan Project of Jilin Province of China","award":["20210302005NC"],"award-info":[{"award-number":["20210302005NC"]}]},{"name":"Zhejiang Lab","award":["2021PE0AC04"],"award-info":[{"award-number":["2021PE0AC04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MutL homolog 1 (MLH1), a member of the MutL homolog family, is required for normal recombination in most organisms. However, its role in soybean (Glycine max) remains unclear to date. Here, we characterized the Glycine max female and male sterility 1 (Gmfms1) mutation that reduces pollen grain viability and increases embryo sac abortion in soybean. Map-based cloning revealed that the causal gene of Gmfms1 is Glycine max MutL homolog 1 (GmMLH1), and CRISPR\/Cas9 knockout approach further validated that disruption of GmMLH1 confers the female\u2013male sterility phenotype in soybean. Loss of GmMLH1 function disrupted bivalent formation, leading to univalent mis-segregation during meiosis and ultimately to female\u2013male sterility. The Gmmlh1 mutant showed about a 78.16% decrease in meiotic crossover frequency compared to the wild type. The residual chiasmata followed a Poisson distribution, suggesting that interference-sensitive crossover formation was affected in the Gmmlh1 mutant. Furthermore, GmMLH1 could interact with GmMLH3A and GmMLH3B both in vivo and in vitro. Overall, our work demonstrates that GmMLH1 participates in interference-sensitive crossover formation in soybean, and provides additional information about the conserved functions of MLH1 across plant species.<\/jats:p>","DOI":"10.1093\/plphys\/kiae165","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T18:31:58Z","timestamp":1710613918000},"page":"2579-2595","source":"Crossref","is-referenced-by-count":6,"title":["<i>MutL homolog 1<\/i> participates in interference-sensitive meiotic crossover formation in soybean"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-5108","authenticated-orcid":false,"given":"Tao","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-9428","authenticated-orcid":false,"given":"Suxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9075-5528","authenticated-orcid":false,"given":"Junling","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"},{"name":"College of Life Science, Jilin Agricultural University , Changchun 130118 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-5195","authenticated-orcid":false,"given":"Yaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0653-8800","authenticated-orcid":false,"given":"Jinshan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantian","family":"Leng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuanqiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-6275","authenticated-orcid":false,"given":"Javaid Akhter","family":"Bhat","sequence":"additional","affiliation":[{"name":"Zhejiang Lab , Hangzhou 311121 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-3731","authenticated-orcid":false,"given":"Xianzhong","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of 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