{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:32:41Z","timestamp":1771493561336,"version":"3.50.1"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["PID2022-142973NB-I00"],"award-info":[{"award-number":["PID2022-142973NB-I00"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["PID2020-117774GA-I00"],"award-info":[{"award-number":["PID2020-117774GA-I00"]}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Recalibration of the Spanish University System"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nitro-fatty acids (NO2-FAs) have emerged as key components of nitric oxide (NO) signaling in eukaryotes. We previously described how nitro-linolenic acid (NO2-Ln), the major NO2-FA detected in plants, regulates S-nitrosoglutathione (GSNO) levels in Arabidopsis (Arabidopsis thaliana). However, the underlying molecular mechanisms remain undefined. Here, we used a combination of physiological, biochemical, and molecular approaches to provide evidence that NO2-Ln modulates S-nitrosothiol (SNO) content through S-nitrosylation of S-nitrosoglutathione reductase1 (GSNOR1) and its impact on germination onset. The aer mutant (a knockout mutant of the alkenal reductase enzyme; AER) exhibits higher NO2-Ln content and lower GSNOR1 transcript levels, reflected by higher SNO content and S-nitrosylated proteins. Given its capacity to release NO, NO2-Ln mediates the S-nitrosylation of GSNOR1, demonstrating that NO2-FAs can indirectly modulate total SNO content in plants. Moreover, the ectopic application of NO2-Ln to dormant seeds enhances germination success similarly to the aer germination rate, which is mediated by the degradation of master regulator ABSCISIC ACID INSENSITIVE 5 (ABI5). Our results establish that NO2-FAs regulate plant development through NO and SNO metabolism and reveal a role of NO2-FAs in plant physiology.<\/jats:p>","DOI":"10.1093\/plphys\/kiaf038","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T15:51:36Z","timestamp":1737820296000},"source":"Crossref","is-referenced-by-count":7,"title":["Nitro-fatty acids modulate germination onset through <i>S<\/i>-nitrosothiol metabolism"],"prefix":"10.1093","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-7242","authenticated-orcid":false,"given":"Capilla","family":"Mata-P\u00e9rez","sequence":"first","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, University Institute for Research in Olive Groves and Olive Oils, University of Ja\u00e9n , Campus \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]},{"name":"Faculty of Biology, Institute for Agribiotechnology Research (CIALE), University of Salamanca , E-37185 Salamanca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-4597","authenticated-orcid":false,"given":"Juan C","family":"Begara-Morales","sequence":"additional","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, University Institute for Research in Olive Groves and Olive Oils, University of Ja\u00e9n , Campus \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda N","family":"Padilla","sequence":"additional","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, University Institute for Research in Olive Groves and Olive Oils, University of Ja\u00e9n , Campus \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-7012","authenticated-orcid":false,"given":"Mounira","family":"Chaki","sequence":"additional","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, University Institute for Research in Olive Groves and Olive Oils, University of Ja\u00e9n , Campus \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1280","authenticated-orcid":false,"given":"Beatriz","family":"S\u00e1nchez-Calvo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Research Center (CEINBIO), School of Medicine, University of the Republic , 11800 Montevideo 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Faculty of Experimental Sciences, University Institute for Research in Olive Groves and Olive Oils, University of Ja\u00e9n , Campus \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2210-9547","authenticated-orcid":false,"given":"Manuel","family":"Melguizo","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Organic Chemistry, Faculty of Experimental Sciences, University of Ja\u00e9n , Campus Universitario \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2253-0101","authenticated-orcid":false,"given":"Raquel","family":"Valderrama","sequence":"additional","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, University Institute for Research in Olive Groves and Olive Oils, University of Ja\u00e9n , Campus \u201cLas Lagunillas\u201d s\/n, E-23071 Ja\u00e9n ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-5578","authenticated-orcid":false,"given":"Inmaculada","family":"S\u00e1nchez-Vicente","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute for Agribiotechnology Research (CIALE), University of Salamanca , E-37185 Salamanca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-0789","authenticated-orcid":false,"given":"\u00d3scar","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute for Agribiotechnology Research (CIALE), University of Salamanca , E-37185 Salamanca 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