{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:14:59Z","timestamp":1787242499045,"version":"build-2736575974"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD2201302"],"award-info":[{"award-number":["2024YFD2201302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Chongqing, China","award":["cstc2021jcyj-cxtt0005"],"award-info":[{"award-number":["cstc2021jcyj-cxtt0005"]}]},{"name":"Special Funding for Postdoctoral Research","award":["2023CQBSHTB3069"],"award-info":[{"award-number":["2023CQBSHTB3069"]}]},{"name":"Innovation Research 2035 Pilot Plan of Southwest University","award":["SWU-XDZD22008"],"award-info":[{"award-number":["SWU-XDZD22008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>1-Deoxynojirimycin (DNJ) is an iminosugar with notable pharmacological properties, and mulberry (Morus spp.) represents the richest natural source of this compound, particularly in young leaves and roots. Despite its tissue-specific distribution, the transcriptional regulatory mechanisms underlying its biosynthesis remain poorly understood. In this study, we integrated transcriptomic profiling, molecular assays, and phytohormone analyses to uncover a multilayered transcriptional network controlling DNJ biosynthesis in mulberry. Weighted gene co-expression network analysis identified a DNJ-associated module (MEblue) that includes 4 potential transcription factors: zinc-finger homeodomain-6 (ZFHD6), HOMEODOMAIN GLABROUS11 (HDG11), TEOSINTE BRANCHED1\/CYCLOIDEA\/PROLIFERATING CELL FACTOR-14 (TCP14), and ARABIDOPSIS THALIANA HOMEBOX-40 (ATHB40). ZFHD6, TCP14, and ATHB40 directly interacted with and activated the MnGutB1 promoter, a key biosynthetic gene. Although HDG11 did not target MnGutB1 directly, it transcriptionally activated ZFHD6, TCP14, and ATHB40, and formed protein complexes with TCP14 or ATHB40, thereby indirectly promoting DNJ biosynthesis. Furthermore, exogenous application of trans-zeatin riboside or abscisic acid induced HDG11 and MnGutB1 expression, concomitant with elevated DNJ levels. Our findings identify an HDG11-centered regulatory hierarchy that integrates phytohormonal and developmental signals to regulate DNJ biosynthesis, offering insights for metabolic engineering of DNJ production in plants.<\/jats:p>","DOI":"10.1093\/plphys\/kiaf567","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:46:37Z","timestamp":1762674397000},"source":"Crossref","is-referenced-by-count":7,"title":["An HDG11-mediated transcriptional network regulates 1-deoxynojirimycin biosynthesis in mulberry"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2750-253X","authenticated-orcid":false,"given":"Zhen","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeling","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-7957","authenticated-orcid":false,"given":"Xiaoyu","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-9487","authenticated-orcid":false,"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-7113","authenticated-orcid":false,"given":"Ningjia","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, Southwest University , Chongqing 400715 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"issue":"5","key":"2025112007465431700_kiaf567-B1","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1105\/tpc.106.048041","article-title":"ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis","volume":"19","author":"Adie","year":"2007","journal-title":"Plant Cell"},{"issue":"12","key":"2025112007465431700_kiaf567-B2","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1105\/tpc.104.025833","article-title":"Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis","volume":"16","author":"Anderson","year":"2004","journal-title":"Plant Cell"},{"issue":"5","key":"2025112007465431700_kiaf567-B3","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1021\/np9705726","article-title":"Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis","volume":"61","author":"Asano","year":"1998","journal-title":"J Nat Prod"},{"issue":"3","key":"2025112007465431700_kiaf567-B4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0031-9422(99)00555-5","article-title":"Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae)","volume":"53","author":"Asano","year":"2000","journal-title":"Phytochemistry"},{"key":"2025112007465431700_kiaf567-B5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0008-6215(94)80068-5","article-title":"Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis","volume":"253","author":"Asano","year":"1994","journal-title":"Carbohydr Res"},{"key":"2025112007465431700_kiaf567-B6","doi-asserted-by":"publisher","first-page":"138588","DOI":"10.1016\/j.ijbiomac.2024.138588","article-title":"MYB proteins: versatile regulators of plant development, stress responses, and secondary metabolite biosynthetic pathways","volume":"288","author":"Bhatt","year":"2025","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"2025112007465431700_kiaf567-B7","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1128\/AAC.01457-08","article-title":"Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses","volume":"53","author":"Chang","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"2025112007465431700_kiaf567-B8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.tplants.2017.12.006","article-title":"Combinatorial transcriptional control of plant specialized metabolism","volume":"23","author":"Colinas","year":"2018","journal-title":"Trends Plant Sci"},{"key":"2025112007465431700_kiaf567-B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fct.2014.11.001","article-title":"1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice","volume":"75","author":"Do","year":"2015","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"2025112007465431700_kiaf567-B10","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1039\/C1RA00910A","article-title":"Targeted drugs by olefin metathesis: piperidine-based iminosugars","volume":"2","author":"Dragutan","year":"2012","journal-title":"RSC Adv."},{"issue":"19","key":"2025112007465431700_kiaf567-B11","doi-asserted-by":"publisher","first-page":"8987","DOI":"10.1128\/JVI.75.19.8987-8998.2001","article-title":"Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus","volume":"75","author":"Durantel","year":"2001","journal-title":"J Virol"},{"issue":"1","key":"2025112007465431700_kiaf567-B12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1104\/pp.20.00433","article-title":"Plant secondary metabolites as defenses, regulators, and primary metabolites: the blurred functional trichotomy","volume":"184","author":"Erb","year":"2020","journal-title":"Plant Physiol"},{"issue":"1","key":"2025112007465431700_kiaf567-B13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1055\/s-2006-960448","article-title":"Comparison between in vivo and in vitro metabolite production of Morus nigra","volume":"65","author":"Ferrari","year":"1999","journal-title":"Planta Med"},{"issue":"5","key":"2025112007465431700_kiaf567-B14","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1111\/nph.17453","article-title":"AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua","volume":"231","author":"Fu","year":"2021","journal-title":"New Phytol"},{"issue":"3","key":"2025112007465431700_kiaf567-B15","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1111\/nph.20081","article-title":"CmMYC2-CmMYBML1 module orchestrates the resistance to herbivory by synchronously regulating the trichome development and constitutive terpene biosynthesis in Chrysanthemum","volume":"244","author":"Guan","year":"2024","journal-title":"New Phytol"},{"key":"2025112007465431700_kiaf567-B16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.foodchem.2018.01.058","article-title":"Seasonal variations of iminosugars in mulberry leaves detected by hydrophilic interaction chromatography coupled with tandem mass spectrometry","volume":"251","author":"Han","year":"2018","journal-title":"Food Chem"},{"issue":"30","key":"2025112007465431700_kiaf567-B17","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1016\/S0040-4020(01)81840-8","article-title":"The biosynthesis of 1-deoxynojirimycin in Bacillus subtilis var Niger","volume":"49","author":"Hardicka","year":"1993","journal-title":"Tetrahedron"},{"issue":"30","key":"2025112007465431700_kiaf567-B18","doi-asserted-by":"publisher","first-page":"6285","DOI":"10.1016\/S0040-4020(01)88220-X","article-title":"Glucose is a precursor of 1-deoxynojirimycin and 1-deoxymannonojirimycin in Streptomyces subrutilus","volume":"48","author":"Hardick","year":"1992","journal-title":"Tetrahedron"},{"issue":"1","key":"2025112007465431700_kiaf567-B19","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1038\/ncomms3445","article-title":"Draft genome sequence of the mulberry tree Morus notabilis","volume":"4","author":"He","year":"2013","journal-title":"Nat Commun"},{"key":"2025112007465431700_kiaf567-B20","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.indcrop.2013.06.030","article-title":"Quantitative determination of 1-deoxynojirimycin in mulberry leaves from 132 varieties","volume":"49","author":"Hu","year":"2013","journal-title":"Ind Crops Prod"},{"issue":"19","key":"2025112007465431700_kiaf567-B21","doi-asserted-by":"publisher","first-page":"10166","DOI":"10.1093\/nar\/gkz754","article-title":"Conserved HORMA domain-containing protein Hop1 stabilizes interaction between proteins of meiotic DNA break hotspots and chromosome axis","volume":"47","author":"Kariyazono","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"2025112007465431700_kiaf567-B22","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1104\/pp.107.115717","article-title":"Jasmonate signaling: toward an integrated view","volume":"146","author":"Kazan","year":"2008","journal-title":"Plant Physiol"},{"issue":"14","key":"2025112007465431700_kiaf567-B23","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.1021\/jf062680g","article-title":"Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans","volume":"55","author":"Kimura","year":"2007","journal-title":"J Agric Food Chem"},{"issue":"2","key":"2025112007465431700_kiaf567-B24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3164\/jcbn.10-53","article-title":"Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans","volume":"47","author":"Kojima","year":"2010","journal-title":"J Clin Biochem Nutr"},{"issue":"8","key":"2025112007465431700_kiaf567-B25","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1021\/jf073223i","article-title":"Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models","volume":"56","author":"Kong","year":"2008","journal-title":"J Agric Food Chem"},{"issue":"10","key":"2025112007465431700_kiaf567-B26","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s13205-021-02970-x","article-title":"Emerging roles of NAC transcription factor in medicinal plants: progress and prospects","volume":"11","author":"Kumar","year":"2021","journal-title":"3 Biotech"},{"issue":"15","key":"2025112007465431700_kiaf567-B27","doi-asserted-by":"publisher","first-page":"7330","DOI":"10.1016\/j.bmc.2008.06.026","article-title":"In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures","volume":"16","author":"Kuriyama","year":"2008","journal-title":"Bioorgan Med Chem"},{"issue":"14","key":"2025112007465431700_kiaf567-B28","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.1073\/pnas.1103010108","article-title":"Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco","volume":"108","author":"Lackman","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2025112007465431700_kiaf567-B29","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.antiviral.2007.04.004","article-title":"Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity","volume":"76","author":"Lazar","year":"2007","journal-title":"Antiviral Res."},{"issue":"5","key":"2025112007465431700_kiaf567-B30","doi-asserted-by":"publisher","first-page":"637","DOI":"10.4014\/jmb.1209.09043","article-title":"1-Deoxynojirimycin isolated from a Bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes","volume":"23","author":"Lee","year":"2013","journal-title":"J Microbiol Biotechnol"},{"key":"2025112007465431700_kiaf567-B31","doi-asserted-by":"publisher","first-page":"RP95891","DOI":"10.7554\/eLife.95891","article-title":"Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)","volume":"13","author":"Lin","year":"2024","journal-title":"eLife"},{"key":"2025112007465431700_kiaf567-B32","doi-asserted-by":"publisher","first-page":"697702","DOI":"10.3389\/fpls.2021.697702","article-title":"Transcriptome and DNA methylome reveal insights into phytoplasma infection responses in mulberry (Morus multicaulis Perr.)","volume":"12","author":"Liu","year":"2021","journal-title":"Front Plant Sci"},{"issue":"44","key":"2025112007465431700_kiaf567-B33","doi-asserted-by":"publisher","first-page":"12345","DOI":"10.1021\/acs.jafc.0c04832","article-title":"Comparative transcriptome analysis of key reductase genes involved in the 1-deoxynojirimycin biosynthetic pathway in mulberry leaves and cloning, prokaryotic expression, and functional analysis of MaSDR1 and MaSDR2","volume":"68","author":"Liu","year":"2020","journal-title":"J Agric Food Chem"},{"issue":"8","key":"2025112007465431700_kiaf567-B34","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00299-018-2295-4","article-title":"Lysm1 in MmLYK2 is a motif required for the interaction of MmLYP1 and MmLYK2 in the chitin signaling","volume":"37","author":"Lv","year":"2018","journal-title":"Plant Cell Rep"},{"issue":"7","key":"2025112007465431700_kiaf567-B35","doi-asserted-by":"publisher","first-page":"uhad111","DOI":"10.1093\/hr\/uhad111","article-title":"The gap-free genome of mulberry elucidates the architecture and evolution of polycentric chromosomes","volume":"10","author":"Ma","year":"2023","journal-title":"Hortic Res"},{"issue":"11","key":"2025112007465431700_kiaf567-B36","doi-asserted-by":"publisher","first-page":"eaas9357","DOI":"10.1126\/sciadv.aas9357","article-title":"Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua","volume":"4","author":"Ma","year":"2018","journal-title":"Sci Adv"},{"issue":"2","key":"2025112007465431700_kiaf567-B37","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1104\/pp.104.058032","article-title":"The Arabidopsis transcription factor MYB12 is a flavonol-specific regulator of phenylpropanoid biosynthesis","volume":"138","author":"Mehrtens","year":"2005","journal-title":"Plant Physiol"},{"issue":"9","key":"2025112007465431700_kiaf567-B38","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1111\/pbi.13101","article-title":"Development of an efficient root transgenic system for pigeon pea and its application to other important economically plants","volume":"17","author":"Meng","year":"2019","journal-title":"Plant Biotechnol J"},{"issue":"12","key":"2025112007465431700_kiaf567-B39","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1271\/bbb.110407","article-title":"Effect of environmental conditions on the \u03b1-glucosidase inhibitory activity of mulberry leaves","volume":"75","author":"Nakanishi","year":"2011","journal-title":"Biosci Biotech Bioch"},{"issue":"6","key":"2025112007465431700_kiaf567-B40","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/0003-9969(83)90186-3","article-title":"Inhibition by acarbose, nojirimycin and 1-deoxynojirimycin of glucosyltransferase produced by oral streptococci","volume":"28","author":"Newbrun","year":"1983","journal-title":"Arch Oral Biol"},{"issue":"4","key":"2025112007465431700_kiaf567-B41","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.jpba.2007.03.031","article-title":"Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography\u2013tandem mass spectrometry","volume":"44","author":"Nuengchamnong","year":"2007","journal-title":"J Pharm Biomed Anal"},{"key":"2025112007465431700_kiaf567-B42","first-page":"262","article-title":"Production of 1-deoxynojirimycin by Streptomyces sp. SID9135","volume":"7","author":"Paek","year":"1997","journal-title":"J Microbiol Biotechnol"},{"issue":"1","key":"2025112007465431700_kiaf567-B43","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1124\/mol.61.1.186","article-title":"The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step","volume":"61","author":"Papandr\u00e9ou","year":"2002","journal-title":"Mol Pharmacol"},{"issue":"19","key":"2025112007465431700_kiaf567-B44","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1080\/10408398.2021.1989660","article-title":"A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-\u03b1-d-galactopyranosyl-DNJ","volume":"63","author":"Parida","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"7","key":"2025112007465431700_kiaf567-B45","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1093\/jxb\/erx484","article-title":"SmJAZ8 acts as a core repressor regulating JA-induced biosynthesis of salvianolic acids and tanshinones in Salvia miltiorrhiza hairy roots","volume":"69","author":"Pei","year":"2018","journal-title":"J Exp Bot"},{"issue":"5","key":"2025112007465431700_kiaf567-B46","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00438-014-0851-3","article-title":"Cloning and expression analyses of the anthocyanin biosynthetic genes in mulberry plants","volume":"289","author":"Qi","year":"2014","journal-title":"Mol Genet Genomics"},{"issue":"6","key":"2025112007465431700_kiaf567-B47","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.2337\/dc20-2109","article-title":"Efficacy and safety of mulberry twig alkaloids tablet for the treatment of type 2 diabetes: a multicenter, randomized, double-blind, double-dummy, and parallel controlled clinical trial","volume":"44","author":"Qu","year":"2021","journal-title":"Diabetes Care"},{"issue":"0","key":"2025112007465431700_kiaf567-B48","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1039\/CT9171100876","article-title":"LXXV.\u2014a theory of the mechanism of the phytochemical synthesis of certain alkaloids","volume":"111","author":"Robinson","year":"1917","journal-title":"J Chem Soc Trans"},{"issue":"19","key":"2025112007465431700_kiaf567-B49","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1016\/j.phytochem.2004.08.013","article-title":"Biosynthesis of 1-deoxynojirimycin in Commelina communis: a difference between the microorganisms and plants","volume":"65","author":"Shibano","year":"2004","journal-title":"Phytochemistry"},{"key":"2025112007465431700_kiaf567-B50","first-page":"251","article-title":"Determination of 1-deoxynojirimycin and 2, 5-dihydroxymethyl 3, 4-dihydroxypyrrolidine contents of Commelina communis var. hortensis and the antihyperglycemic activity","volume":"55","author":"Shibano","year":"2001","journal-title":"Nat Med"},{"issue":"2","key":"2025112007465431700_kiaf567-B51","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1104\/pp.18.00293","article-title":"Plant hormonomics: multiple phytohormone profiling by targeted metabolomics","volume":"177","author":"\u0160imura","year":"2018","journal-title":"Plant Physiol"},{"issue":"11","key":"2025112007465431700_kiaf567-B52","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1002\/jsfa.7614","article-title":"Effect of solar radiation on the functional components of mulberry (Morus alba L.) leaves","volume":"96","author":"Sugiyama","year":"2016","journal-title":"J Sci Food Agr"},{"issue":"4","key":"2025112007465431700_kiaf567-B53","doi-asserted-by":"publisher","first-page":"534","DOI":"10.2503\/hortj.OKD-053","article-title":"Seasonal changes in functional component contents in mulberry (Morus alba L.) leaves","volume":"86","author":"Sugiyama","year":"2017","journal-title":"Horticult J"},{"issue":"4","key":"2025112007465431700_kiaf567-B54","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1104\/pp.111.181834","article-title":"The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus","volume":"157","author":"Suttipanta","year":"2011","journal-title":"Plant Physiol"},{"issue":"1","key":"2025112007465431700_kiaf567-B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.antiviral.2006.03.016","article-title":"Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3","volume":"72","author":"Tanaka","year":"2006","journal-title":"Antiviral Res."},{"issue":"D1","key":"2025112007465431700_kiaf567-B56","doi-asserted-by":"publisher","first-page":"D1104","DOI":"10.1093\/nar\/gkz1020","article-title":"PlantRegMap: charting functional regulatory maps in plants","volume":"48","author":"Tian","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2025112007465431700_kiaf567-B57","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.lwt.2011.09.008","article-title":"Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction","volume":"45","author":"Vichasilp","year":"2012","journal-title":"LWT - Food Sci Technol"},{"issue":"8","key":"2025112007465431700_kiaf567-B58","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1021\/acs.jafc.6b05212","article-title":"Characterization of stilbene synthase genes in mulberry (Morus atropurpurea) and metabolic engineering for the production of resveratrol in Escherichia coli","volume":"65","author":"Wang","year":"2017","journal-title":"J Agric Food Chem"},{"key":"2025112007465431700_kiaf567-B59","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pep.2018.06.004","article-title":"Cloning, expression, and functional analysis of lysine decarboxylase in mulberry (Morus alba L.)","volume":"151","author":"Wang","year":"2018","journal-title":"Protein Expression Purif"},{"key":"2025112007465431700_kiaf567-B60","doi-asserted-by":"publisher","first-page":"e5443","DOI":"10.7717\/peerj.5443","article-title":"Transcriptome analysis and identification of key genes involved in 1-deoxynojirimycin biosynthesis of mulberry (Morus alba L.)","volume":"6","author":"Wang","year":"2018","journal-title":"PeerJ"},{"issue":"27","key":"2025112007465431700_kiaf567-B61","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1021\/acs.jafc.5b01680","article-title":"Mulberry 1-deoxynojirimycin inhibits adipogenesis by repression of the ERK\/PPAR\u03b3 signaling pathway in porcine intramuscular adipocytes","volume":"63","author":"Wang","year":"2015","journal-title":"J Agric Food Chem"},{"key":"2025112007465431700_kiaf567-B62","doi-asserted-by":"publisher","first-page":"e027","DOI":"10.48130\/forres-0024-0024","article-title":"MGCPdb, a collective resource for mulberry genome size, chromosome number, and ploidy","volume":"4","author":"Wang","year":"2024","journal-title":"For Res (Fayettev)"},{"issue":"4","key":"2025112007465431700_kiaf567-B63","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1111\/nph.18779","article-title":"The regulatory module MdBZR1-MdCOL6 mediates brassinosteroid- and light-regulated anthocyanin synthesis in apple","volume":"238","author":"Wang","year":"2023","journal-title":"New Phytol"},{"key":"2025112007465431700_kiaf567-B64","first-page":"1","article-title":"Optimization of the fermentation conditions for 1-deoxynojirimycin production by Streptomyces lawendulae applying the response surface methodology","volume":"7","author":"Wei","year":"2011","journal-title":"Ind Crops Prod"},{"issue":"30","key":"2025112007465431700_kiaf567-B65","doi-asserted-by":"publisher","first-page":"e2403059","DOI":"10.1002\/advs.202403059","article-title":"Regulation of glandular size and phytoalexin biosynthesis by a negative feedback loop in cotton","volume":"11","author":"Wu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"12","key":"2025112007465431700_kiaf567-B66","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1111\/pbi.12583","article-title":"Altered metabolite accumulation in tomato fruits by coexpressing a feedback-insensitive AroG and the PhODO1 mYB-type transcription factor","volume":"14","author":"Xie","year":"2016","journal-title":"Plant Biotechnol J"},{"issue":"1","key":"2025112007465431700_kiaf567-B67","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41438-021-00588-x","article-title":"Dynamic changes in transposable element and gene methylation in mulberry (Morus notabilis) in response to Botrytis cinerea","volume":"8","author":"Xin","year":"2021","journal-title":"Hortic Res"},{"issue":"4","key":"2025112007465431700_kiaf567-B68","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1093\/plphys\/kiad245","article-title":"PACLOBUTRAZOL-RESISTANCE4 positively regulates cell expansion to promote tendril elongation in cucumber","volume":"192","author":"Xu","year":"2023","journal-title":"Plant Physiol"},{"key":"2025112007465431700_kiaf567-B69","first-page":"571","article-title":"The structure of moranoline, a piperidine alkaloid from Morus species","volume":"50","author":"Yagi","year":"1976","journal-title":"B Agric Chem Soc Jpn"},{"issue":"2","key":"2025112007465431700_kiaf567-B70","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3136\/fstr.23.349","article-title":"Lactose increases the production of 1-deoxynojirimycin in Bacillus amyloliquefaciens","volume":"23","author":"Yamagishi","year":"2017","journal-title":"Food Sci Technol Res"},{"issue":"9","key":"2025112007465431700_kiaf567-B71","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/v10090472","article-title":"Identification of the potential virulence factors and RNA silencing suppressors of mulberry mosaic dwarf-associated geminivirus","volume":"10","author":"Yang","year":"2018","journal-title":"Viruses"},{"issue":"2","key":"2025112007465431700_kiaf567-B72","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1093\/plphys\/kiad065","article-title":"Dehydrogenase MnGutB1 catalyzes 1-deoxynojirimycin biosynthesis in mulberry","volume":"192","author":"Yang","year":"2023","journal-title":"Plant Physiol"},{"issue":"1","key":"2025112007465431700_kiaf567-B73","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11418-007-0185-0","article-title":"The relationship between 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan","volume":"62","author":"Yatsunami","year":"2007","journal-title":"J Nat Med"},{"issue":"3","key":"2025112007465431700_kiaf567-B74","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/nph.18567","article-title":"AabHLH113 integrates jasmonic acid and abscisic acid signaling to positively regulate artemisinin biosynthesis in Artemisia annua","volume":"237","author":"Yuan","year":"2023","journal-title":"New Phytol"},{"issue":"4","key":"2025112007465431700_kiaf567-B75","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1111\/nph.15486","article-title":"Activator-type R2R3-MYB genes induce a repressor-type R2R3-MYB gene to balance anthocyanin and proanthocyanidin accumulation","volume":"221","author":"Zhou","year":"2019","journal-title":"New Phytol"},{"issue":"4","key":"2025112007465431700_kiaf567-B76","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.biotechadv.2016.02.004","article-title":"Jasmonate-responsive transcription factors regulating plant secondary metabolism","volume":"34","author":"Zhou","year":"2016","journal-title":"Biotechnol Adv"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/plphys\/advance-article-pdf\/doi\/10.1093\/plphys\/kiaf567\/65238050\/kiaf567.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/199\/3\/kiaf567\/65238050\/kiaf567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/199\/3\/kiaf567\/65238050\/kiaf567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:46:59Z","timestamp":1763642819000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/doi\/10.1093\/plphys\/kiaf567\/8316277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,10,31]]}},"URL":"https:\/\/doi.org\/10.1093\/plphys\/kiaf567","relation":{},"ISSN":["0032-0889","1532-2548"],"issn-type":[{"value":"0032-0889","type":"print"},{"value":"1532-2548","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,10,31]]},"article-number":"kiaf567"}}