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Unlike other components of this complex, HIZ1 is not expressed constitutively throughout the plant, is not required for m6A deposition, and, when ectopically overexpressed, results in reduced levels of m6A. However, the biological functions of HIZ1 remain unclear. Here, we generated additional HIZ1 constitutive overexpression (HIZ1 OX) lines and selected 8 lines, showing varying levels of expression. These plants exhibited pleiotropic developmental defects, the severity of which correlated with expression level. However, higher levels of HIZ1 overexpression did not reduce m6A levels beyond a 25% decrease, consistent with the complete titration of methylase complex interacting partner(s). Using chromatin immunoprecipitation sequencing (ChIP-seq), we showed that HIZ1 is predominantly associated with predicted gene promoter regions and is significantly enriched on genes whose transcripts in wild-type plants are m6A modified. Our results suggest that constitutive overexpression of HIZ1 promotes vegetative growth and disrupts reproductive growth in Arabidopsis. This likely occurs both through m6A inhibition and transcriptional regulation. Thus, HIZ1 may function in an analogous fashion to the mouse zinc finger protein 217 (ZFP217, human homolog ZNF217), which acts as both a transcriptional regulator and a suppressor of the m6A methylation complex.<\/jats:p>","DOI":"10.1093\/plphys\/kiag303","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:41:52Z","timestamp":1779536512000},"source":"Crossref","is-referenced-by-count":0,"title":["Ectopic expression of the transcriptional regulator and m6A writer complex member HIZ1 impacts development in Arabidopsis"],"prefix":"10.1093","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-5934","authenticated-orcid":false,"given":"Mi","family":"Zhang","sequence":"first","affiliation":[{"name":"Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus , Loughborough LE12 5RD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-1126","authenticated-orcid":false,"given":"Nigel P","family":"Mongan","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington Campus , Loughborough LE12 5RD ,","place":["United Kingdom"]},{"name":"Department of Pharmacology, Weill Cornell Medicine , NewYork, NY 10065 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-6161","authenticated-orcid":false,"given":"Nathan","family":"Archer","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington Campus , Loughborough LE12 5RD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-8945","authenticated-orcid":false,"given":"Rupert G","family":"Fray","sequence":"additional","affiliation":[{"name":"Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus , Loughborough LE12 5RD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026063009012408400_kiag303-B1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.stem.2015.09.005","article-title":"Coordination of m6A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming","volume":"17","author":"Aguilo","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2026063009012408400_kiag303-B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2023.108255","article-title":"ECT12, an YTH-domain protein, is a potential mRNA m6A reader that affects abiotic stress responses by modulating mRNA stability in Arabidopsis","volume":"206","author":"Amara","year":"2024","journal-title":"Plant Physiol Biochem"},{"key":"2026063009012408400_kiag303-B3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev.arplant.59.032607.092759","article-title":"Chlorophyll fluorescence: a probe of photosynthesis in vivo","volume":"59","author":"Baker","year":"2008","journal-title":"Annu Rev Plant Biol"},{"key":"2026063009012408400_kiag303-B4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.stem.2014.09.019","article-title":"M6a RNA modification controls cell fate transition in mammalian embryonic stem cells","volume":"15","author":"Batista","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2026063009012408400_kiag303-B5","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1146\/annurev-arplant-050213-035645","article-title":"Adventitious roots and lateral roots: similarities and differences","volume":"65","author":"Bellini","year":"2014","journal-title":"Annu Rev Plant Biol"},{"key":"2026063009012408400_kiag303-B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2405100121","article-title":"The m6A reader SlYTH2 negatively regulates tomato fruit aroma by impeding the translation process","volume":"121","author":"Bian","year":"2024","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026063009012408400_kiag303-B7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fpls.2012.00048","article-title":"Adenosine methylation in Arabidopsis mRNA is associated with the 3\u2032 end and reduced levels cause developmental defects","volume":"3","author":"Bodi","year":"2012","journal-title":"Front Plant Sci"},{"key":"2026063009012408400_kiag303-B8","doi-asserted-by":"publisher","first-page":"17697","DOI":"10.1016\/S0021-9258(17)32497-3","article-title":"Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. 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