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While the mechanisms underlying iron uptake and accumulation are well studied, the role of light in modulating iron homeostasis remains poorly understood. In this study, we report that blue light enhances iron accumulation thereby positively regulating iron homeostasis in Arabidopsis thaliana. Under iron-deficient (\u2013Fe) conditions, root elongation is specifically promoted by blue light, but not by red light. We further revealed that light perceived by shoots is required for optimum iron accumulation and for iron deficiency\u2013induced increase in root length. The transcription factor HY5 (ELONGATED HYPOCOTYL 5) mediates these blue light\u2013driven responses. The hy5 mutant showed reduced root elongation under \u2013Fe conditions as well as iron accumulation under blue light as compared to wild-type plants. Further we report that CRY1 and CRY2 are the photoreceptor that acts as a connecting link between blue light and HY5 to regulate iron uptake in Arabidopsis. Overall, our work reveals a new regulatory mechanism and offers potential insights into optimizing light conditions to enhance iron accumulation and improve the nutritional quality of crops. Summary Blue light, acting via cryptochromes and the transcription factor HY5, positively regulates iron accumulation in Arabidopsis, revealing a new mechanism for light mediated regulation of iron homeostasis in plants.<\/jats:p>","DOI":"10.1093\/plphys\/kiag366","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:06:40Z","timestamp":1781453200000},"source":"Crossref","is-referenced-by-count":1,"title":["Blue light promotes root iron acquisition via a shoot CRY\u2013HY5 signaling module in Arabidopsis"],"prefix":"10.1093","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8919-3301","authenticated-orcid":false,"given":"Pooja","family":"Jakhar","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research , Mohali, Punjab 140306 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