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Here, we combined ubiquitinated peptide immunoaffinity enrichment with 4D label-free quantitative proteomics to profile protein abundance and protein ubiquitination in infected sweet orange leaves. Infection caused extensive proteome remodeling and a strong global increase in protein ubiquitination. Integrated analysis revealed a predominant group of proteins with reduced abundance and increased ubiquitination, pointing to ubiquitination-associated depletion of proteins involved in chloroplast function, redox homeostasis, and primary metabolism. The degradation machinery itself was also remodeled, including widespread ubiquitination of proteasome subunits and increased proteasome-dependent bulk protein turnover. Physiological and biochemical analyses showed that infection suppressed the hydrogen peroxide-scavenging system, with reduced abundance and increased ubiquitination of catalase, accompanied by elevated hydrogen peroxide accumulation. We also identified actin as a major downstream target of CLas-induced proteostasis remodeling. Actin proteins underwent enhanced ubiquitination and degradation in infected tissues, accompanied by actin filament disruption, and CsACT7 showed 26S proteasome-dependent degradation. Seven CLas-upregulated ubiquitination sites acted cooperatively to promote CsACT7 degradation, as simultaneous substitution of all 7 lysines with alanine strongly stabilized CsACT7 and reduced CLas accumulation in citrus hairy roots. Together, these findings establish ubiquitination-dependent proteome remodeling as a central feature of the citrus response to CLas infection and link ubiquitination-mediated posttranslational regulation to redox imbalance, cytoskeletal disruption, and disease susceptibility.<\/jats:p>","DOI":"10.1093\/plphys\/kiag612","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:24:23Z","timestamp":1787570663000},"source":"Crossref","is-referenced-by-count":0,"title":["Ubiquitination-driven proteostasis remodeling underlies oxidative stress and actin degradation in citrus huanglongbing"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-8875","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"first","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]},{"name":"Jiangxi Provincial Key Laboratory of Pest and Disease Control of Featured Horticultural Plants, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2014-852X","authenticated-orcid":false,"given":"Hongkun","family":"Qin","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4088-2233","authenticated-orcid":false,"given":"Yundan","family":"Hu","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4588-7134","authenticated-orcid":false,"given":"Bingqian","family":"Qin","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6244-4625","authenticated-orcid":false,"given":"Zirui","family":"Fan","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2399-0571","authenticated-orcid":false,"given":"Mingzhuo","family":"Li","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6919-1898","authenticated-orcid":false,"given":"Yaping","family":"Mao","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3066-4182","authenticated-orcid":false,"given":"Fajin","family":"Liao","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-6335","authenticated-orcid":false,"given":"Zhigang","family":"Ouyang","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]},{"name":"Jiangxi Provincial Key Laboratory of Pest and Disease Control of Featured Horticultural Plants, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-3144","authenticated-orcid":false,"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University , Shanghai 200240 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3751-7970","authenticated-orcid":false,"given":"Shuo","family":"Duan","sequence":"additional","affiliation":[{"name":"National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University , Ganzhou 341000 ,","place":["China"]},{"name":"Jiangxi Provincial Key Laboratory of Pest and Disease Control of Featured Horticultural Plants, Gannan Normal University , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026091501370652100_kiag612-B1","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1016\/j.cell.2022.08.011","article-title":"Actin cytoskeleton remodeling primes RIG-I-like receptor 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