{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:57Z","timestamp":1789556877772,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360742"],"award-info":[{"award-number":["82360742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources","award":["2060302"],"award-info":[{"award-number":["2060302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Panax notoginseng is an economically vital medicinal plant, prized for its bioactive P. notoginseng saponins (PNS), which possess significant therapeutic effects in cardiovascular and cerebrovascular diseases. Despite the elucidation of the core enzymatic steps in PNS biosynthesis, the posttranscriptional mechanisms that coordinate these metabolic fluxes remain largely obscure. This study explored the Pn-miR160a-ARF4 module as a pivotal regulation mode in the biosynthesis of PNS. Under methyl jasmonate stimulation, Pn-miR160a was significantly upregulated, subsequently targeting and cleaving the transcripts of auxin response factor 4 (PnARF4). This targeted silencing of PnARF4 effectively relieves its transcriptional repression, thereby promoting the expression of downstream biosynthetic genes and increasing PNS yield. By integrating hormonal signaling with miRNA-mediated gene silencing, these results uncover a sophisticated regulatory axis that governs specialized metabolism. Furthermore, this work expands the known functional scope of the evolutionarily conserved miR160-ARF module beyond its traditional role in plant architecture and auxin signaling, repositioning it as a central component of secondary metabolic regulation. These findings provide a theoretical foundation and a robust molecular target for the metabolic engineering and genetic improvement of P. notoginseng quality.<\/jats:p>","DOI":"10.1093\/plphys\/kiag656","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:22:05Z","timestamp":1788423725000},"source":"Crossref","is-referenced-by-count":0,"title":["miR160a-ARF4 module regulates the biosynthesis of\n                    <i>Panax notoginseng<\/i>\n                    saponins"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1572-3073","authenticated-orcid":false,"given":"Wenqing","family":"Li","sequence":"first","affiliation":[{"name":"Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Chenggong District Yunnan Key Laboratory of Sustainable Utilization of Panax notoginseng Resources, , Kunming 650500 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs , National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Inner Dongzhimen, Dongcheng District, Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0584-1219","authenticated-orcid":false,"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Chenggong District Yunnan Key Laboratory of Sustainable Utilization of Panax notoginseng Resources, , Kunming 650500 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs , National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Inner Dongzhimen, Dongcheng District, Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Chenggong District Yunnan Key Laboratory of Sustainable Utilization of Panax notoginseng Resources, , Kunming 650500 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs , National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Inner Dongzhimen, Dongcheng District, Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Chenggong District Yunnan Key Laboratory of Sustainable Utilization of Panax notoginseng Resources, , Kunming 650500 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs , National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Inner Dongzhimen, Dongcheng District, Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-7120","authenticated-orcid":false,"given":"Feng","family":"Ge","sequence":"additional","affiliation":[{"name":"Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Chenggong District Yunnan Key Laboratory of Sustainable Utilization of Panax notoginseng Resources, , Kunming 650500 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs , National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Inner Dongzhimen, Dongcheng District, Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026091606313781000_kiag656-B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112171","article-title":"Stimulation of health-promoting triterpenoids accumulation in Centella asiatica (L.) 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