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However, the molecular mechanisms involved are not fully understood. Here, we isolated a rice mutant ecdr1 (enhanced cell death and resistance 1) that displayed an autoimmunity phenotype and enhanced resistance to rice blast and bacterial blight, and we identified ECDR1 as a new shared component in phosphoinositide 3-kinase (PI3K) and PI4K complexes, linking the hyccin-containing protein with plant defense responses. ECDR1 was expressed at all developmental stages and in all tissues examined. The ECDR1 protein was highly conserved in function across monocots and dicots. The 113 bp deletion in the ECDR1 promoter reduced its expression, leading to cell death and enhanced disease resistance. The ECDR1 protein was localized in plasma membrane and interacted with tetratricopeptide repeat protein 1 (TPR1) and TPR2, which in turn interacted with both PI4K1 and PI3K1, suggesting that ECDR1 could function as a component associated with not only PI4K complexes but also PI3K complexes to help catalyze PI into phosphatidylinositol 3-phosphate (PI3P) and PI4P. The lethality of all homozygous ecdr1, pi3k1, tpr1 and tpr2 mutants indicated the crucial roles of these genes in plant normal growth, which restricted our understanding of PI3K and PI4K functions. Alternatively, exogenous application of PI3K and PI4K inhibitors could substantially exacerbate the cell death and enhance disease resistance, implying their roles in plant immunity. Our findings provide novel insights into the regulatory mechanisms of ECDR1 in cell death and defense pathways, will aid in understanding the functions of PI3K and PI4K in plant immunity.<\/jats:p>","DOI":"10.1093\/plphys\/kiag663","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:35:08Z","timestamp":1788521708000},"source":"Crossref","is-referenced-by-count":0,"title":["The hyccin-containing protein ECDR1 interacts with PI3K1 and PI4K1 and regulates broad-spectrum disease resistance in rice"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5868-8763","authenticated-orcid":false,"given":"Shuang","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 ,","place":["China"]},{"name":"State Key Laboratory for Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, National Observation and Research Station of Rice Germplasm Resources, Nanjing Agricultural University , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2074-0639","authenticated-orcid":false,"given":"Lingzhi","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-6922","authenticated-orcid":false,"given":"Zhichao","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9209-4843","authenticated-orcid":false,"given":"Changyan","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2695-5889","authenticated-orcid":false,"given":"Chen","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7976-1362","authenticated-orcid":false,"given":"Xiaokang","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, National Observation and Research Station of Rice Germplasm Resources, Nanjing Agricultural University , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-5881","authenticated-orcid":false,"given":"Ling","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, National Observation and Research Station of Rice Germplasm Resources, Nanjing Agricultural University , Nanjing 210095 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