{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:54:38Z","timestamp":1792151678851,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-Level Talent Special Support Program of Zhejiang Province"},{"name":"Natural Science Foundation of Zhejiang"},{"name":"Research on Key Molecular Design Breeding Technologies of Northern Hybrid Japonica Rice"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heat stress (HS) severely threatens rice (Oryza sativa) growth, development, and yield formation; elucidating regulatory mechanisms underlying rice thermotolerance is essential. Here, we dissected the role of OsMYBR17, a previously uncharacterized R2R3-MYB transcription factor, in the heat-stress responses of rice using gain- and loss-of-function approaches combined with DNA affinity purification sequencing (DAP-seq) and RNA sequencing (RNA-seq). The results indicated that OsMYBR17 was induced by HS. Overexpression of OsMYBR17 markedly enhanced seedling thermotolerance, whereas CRISPR\/Cas9-mediated knockout lines exhibited pronounced heat hypersensitivity. OsMYBR17-overexpression plants accumulated less reactive oxygen species and exhibited reduced lipid peroxidation, as reflected by lower malondialdehyde levels, accompanied by elevated ascorbate peroxidase activity. Consistently, chloroplast structural integrity and chlorophyll-associated signals were better maintained in overexpression lines under prolonged heat exposure, while opposite trends were observed in knockout mutants. Integrative analysis of DAP-seq and RNA-seq identified multiple heat- and oxidative stress-associated candidate targets regulated by OsMYBR17, among which OsLEA4 emerged as a prominent target. Further analyses demonstrated that OsMYBR17 recognized specific cis-elements in the OsLEA4 promoter and directly activated its transcription. Functional analysis of OsLEA4 gain- and loss-of-function materials, together with genetic analysis in the OsMYBR17-overexpression background, further supported its positive contribution to thermotolerance. Collectively, our findings establish an OsMYBR17\u2013OsLEA4 regulatory module that enhances rice heat tolerance and is associated with improved redox homeostasis and chloroplast stability under HS. This study advances our understanding of the molecular basis of heat-stress tolerance in rice and highlights OsMYBR17 and OsLEA4 as potential targets for developing heat-resilient rice cultivars.<\/jats:p>","DOI":"10.1093\/plphys\/kiag686","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:28:29Z","timestamp":1789496909000},"source":"Crossref","is-referenced-by-count":0,"title":["OsMYBR17 enhances thermotolerance in rice by activating\n                    <i>OsLEA4<\/i>\n                    and reinforcing antioxidant defense"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-9314","authenticated-orcid":false,"given":"He","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121 ,","place":["China"]},{"name":"Seed Industry Innovation Research Institute, Liaoning Academy of Agricultural Sciences, No. 84 Dongling Road, Shenhe District, Shenyang, Liaoning 110161 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6572-594X","authenticated-orcid":false,"given":"Yaohuang","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-1878","authenticated-orcid":false,"given":"Banpu","family":"Ruan","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Seed Industry Innovation Research Institute, Liaoning Academy of Agricultural Sciences, No. 84 Dongling Road, Shenhe District, Shenyang, Liaoning 110161 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1850-7948","authenticated-orcid":false,"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-3882","authenticated-orcid":false,"given":"Limin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1176-7107","authenticated-orcid":false,"given":"Jian","family":"Wei","sequence":"additional","affiliation":[{"name":"Faculty of Agronomy, Jilin Agricultural University, No. 2888 Xincheng Street, Changchun, Jilin 130118 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6697-281X","authenticated-orcid":false,"given":"Dianrong","family":"Ma","sequence":"additional","affiliation":[{"name":"Liaoning Academy of Agricultural Sciences, No. 84 Dongling Road, Shenhe District, Shenyang, Liaoning 110161 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2401-316X","authenticated-orcid":false,"given":"Yanchun","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2026101607222331100_kiag686-B1","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1105\/tpc.114.127316","article-title":"The ubiquitous distribution of late embryogenesis abundant proteins across cell compartments in Arabidopsis offers tailored protection against abiotic stress","volume":"26","author":"Candat","year":"2014","journal-title":"Plant Cell"},{"key":"2026101607222331100_kiag686-B2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12864-016-2659-5","article-title":"Expression of OsMYB55 in maize activates stress-responsive genes and enhances heat and drought tolerance","volume":"17","author":"Casaretto","year":"2016","journal-title":"BMC Genomics"},{"key":"2026101607222331100_kiag686-B3","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1111\/tpj.15019","article-title":"Activation tagging identifies Arabidopsis transcription factor AtMYB68 for heat and drought tolerance at yield determining reproductive stages","volume":"104","author":"Deng","year":"2020","journal-title":"Plant J"},{"key":"2026101607222331100_kiag686-B4","doi-asserted-by":"publisher","first-page":"814","DOI":"10.3390\/plants9070814","article-title":"Late embryogenesis abundant protein-client protein interactions","volume":"9","author":"Dirk","year":"2020","journal-title":"Plants (Basel)"},{"key":"2026101607222331100_kiag686-B5","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1038\/s41467-020-16403-5","article-title":"UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice","volume":"11","author":"Dong","year":"2020","journal-title":"Nat Commun"},{"key":"2026101607222331100_kiag686-B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052030","article-title":"The rice R2R3-MYB transcription factor OsMYB55 is involved in the tolerance to high temperature and modulates amino acid metabolism","volume":"7","author":"El-Kereamy","year":"2012","journal-title":"PLoS One"},{"key":"2026101607222331100_kiag686-B7","doi-asserted-by":"publisher","first-page":"6803","DOI":"10.1093\/jxb\/erv386","article-title":"A stress-responsive NAC transcription factor SNAC3 confers heat and drought tolerance through modulation of reactive oxygen species in rice","volume":"66","author":"Fang","year":"2015","journal-title":"J Exp Bot"},{"key":"2026101607222331100_kiag686-B8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/nph.17383","article-title":"Growth-defense trade-offs and yield loss in plants with engineered cell walls","volume":"231","author":"Ha","year":"2021","journal-title":"New Phytol"},{"key":"2026101607222331100_kiag686-B9","doi-asserted-by":"publisher","first-page":"6525","DOI":"10.1093\/jxb\/erac293","article-title":"LEAfing through literature: late embryogenesis abundant proteins coming of age-achievements and perspectives","volume":"73","author":"Hernandez-Sanchez","year":"2022","journal-title":"J Exp Bot"},{"key":"2026101607222331100_kiag686-B10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021178","article-title":"Protein disorder in plant stress adaptation: from late embryogenesis abundant to other intrinsically disordered proteins","volume":"25","author":"Hsiao","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026101607222331100_kiag686-B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2023.108190","article-title":"Lipidomics-based insights into the physiological mechanism of wheat in response to heat stress","volume":"205","author":"Hu","year":"2023","journal-title":"Plant Physiol Biochem"},{"key":"2026101607222331100_kiag686-B12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12010-011-9418-5","article-title":"Molecular analysis of OsLEA4 and its contributions to improve E. coli viability","volume":"166","author":"Hu","year":"2012","journal-title":"Appl Biochem Biotechnol"},{"key":"2026101607222331100_kiag686-B13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.envexpbot.2015.10.002","article-title":"Overexpression of OsLEA4 enhances drought, high salt and heavy metal stress tolerance in transgenic rice (Oryza sativa L.)","volume":"123","author":"Hu","year":"2016","journal-title":"Environ Exp Bot"},{"key":"2026101607222331100_kiag686-B14","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41467-023-36227-3","article-title":"HSFA1a modulates plant heat stress responses and alters the 3D chromatin organization of enhancer-promoter interactions","volume":"14","author":"Huang","year":"2023","journal-title":"Nat Commun"},{"key":"2026101607222331100_kiag686-B15","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1093\/mp\/ssu049","article-title":"Growth-defense tradeoffs in plants: a balancing act to optimize fitness","volume":"7","author":"Huot","year":"2014","journal-title":"Mol Plant."},{"key":"2026101607222331100_kiag686-B16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/pbi.12659","article-title":"The heat-shock protein\/chaperone network and multiple stress resistance","volume":"15","author":"Jacob","year":"2017","journal-title":"Plant Biotechnol J"},{"key":"2026101607222331100_kiag686-B17","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/j.molp.2023.09.013","article-title":"The molecular basis of heat stress responses in plants","volume":"16","author":"Kan","year":"2023","journal-title":"Mol Plant"},{"key":"2026101607222331100_kiag686-B18","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1038\/s41467-023-38096-2","article-title":"Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"key":"2026101607222331100_kiag686-B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100675","article-title":"AtMYBS1 negatively regulates heat tolerance by directly repressing the expression of MAX1 required for strigolactone biosynthesis in Arabidopsis","volume":"4","author":"Li","year":"2023","journal-title":"Plant Commun"},{"key":"2026101607222331100_kiag686-B20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/nph.14679","article-title":"MYB30 transcription factor regulates oxidative and heat stress responses through ANNEXIN-mediated cytosolic calcium signaling in Arabidopsis","volume":"216","author":"Liao","year":"2017","journal-title":"New Phytol"},{"key":"2026101607222331100_kiag686-B21","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/pbi.14500","article-title":"CRISPR\/Cas knockout of the NADPH oxidase gene OsRbohB reduces ROS overaccumulation and enhances heat stress tolerance in rice","volume":"23","author":"Liu","year":"2025","journal-title":"Plant Biotechnol J"},{"key":"2026101607222331100_kiag686-B22","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1111\/pbi.13297","article-title":"A membrane-associated NAC transcription factor OsNTL3 is involved in thermotolerance in rice","volume":"18","author":"Liu","year":"2020","journal-title":"Plant Biotechnol J"},{"key":"2026101607222331100_kiag686-B23","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1111\/pbi.70458","article-title":"Heat shock transcription factor OsHsfc1a enhances rice seedling thermotolerance by regulating OsMFT1 and preserving chloroplast structure under heat stress","volume":"24","author":"Lu","year":"2026","journal-title":"Plant Biotechnol J"},{"key":"2026101607222331100_kiag686-B24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrg3901","article-title":"Genetic mechanisms of abiotic stress tolerance that translate to crop yield stability","volume":"16","author":"Mickelbart","year":"2015","journal-title":"Nat Rev Genet"},{"key":"2026101607222331100_kiag686-B25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1104\/pp.110.158964","article-title":"Functional analysis of the group 4 late embryogenesis abundant proteins reveals their relevance in the adaptive response during water deficit in Arabidopsis","volume":"154","author":"Olvera-Carrillo","year":"2010","journal-title":"Plant Physiol"},{"key":"2026101607222331100_kiag686-B26","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.cell.2016.04.038","article-title":"Cistrome and epicistrome features shape the regulatory DNA landscape","volume":"165","author":"O'Malley","year":"2016","journal-title":"Cell"},{"key":"2026101607222331100_kiag686-B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137181","article-title":"The OsERF115\/AP2EREBP110 transcription factor is involved in the multiple stress tolerance to heat and drought in rice plants","volume":"22","author":"Park","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026101607222331100_kiag686-B28","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.998985","article-title":"Genome-wide analysis of UDP-glycosyltransferase gene family and identification of members involved in flavonoid glucosylation in Chinese bayberry (Morella rubra)","volume":"13","author":"Ren","year":"2022","journal-title":"Front Plant Sci"},{"key":"2026101607222331100_kiag686-B29","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/jxb\/erab027","article-title":"A heat stress responsive NAC transcription factor heterodimer plays key roles in rice grain filling","volume":"72","author":"Ren","year":"2021","journal-title":"J Exp Bot"},{"key":"2026101607222331100_kiag686-B30","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050912","article-title":"Overexpression of HVA1 enhances drought and heat stress tolerance in Triticum aestivum doubled haploid plants","volume":"11","author":"Samtani","year":"2022","journal-title":"Cells"},{"key":"2026101607222331100_kiag686-B31","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1111\/tpj.16612","article-title":"Complex plant responses to drought and heat stress under climate change","volume":"117","author":"Sato","year":"2024","journal-title":"Plant J"},{"key":"2026101607222331100_kiag686-B32","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/plphys\/kiad536","article-title":"PEP-ASSOCIATED PROTEIN 3 regulates rice tiller formation and grain yield by controlling chloroplast biogenesis","volume":"194","author":"Seo","year":"2024","journal-title":"Plant Physiol"},{"key":"2026101607222331100_kiag686-B33","doi-asserted-by":"publisher","first-page":"6549","DOI":"10.1038\/s41467-021-26819-2","article-title":"Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana","volume":"12","author":"Sielemann","year":"2021","journal-title":"Nat Commun"},{"key":"2026101607222331100_kiag686-B34","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1104\/pp.107.114496","article-title":"Arabidopsis stromal 70-kD heat shock proteins are essential for plant development and important for thermotolerance of germinating seeds","volume":"146","author":"Su","year":"2008","journal-title":"Plant Physiol"},{"key":"2026101607222331100_kiag686-B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.151746","article-title":"Heat stress may cause a significant reduction of rice yield in China under future climate scenarios","volume":"818","author":"Sun","year":"2022","journal-title":"Sci Total Environ"},{"key":"2026101607222331100_kiag686-B36","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/jxb\/ers335","article-title":"Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2","volume":"64","author":"Suzuki","year":"2013","journal-title":"J Exp Bot"},{"key":"2026101607222331100_kiag686-B37","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s00425-005-0214-8","article-title":"Rice ascorbate peroxidase gene family encodes functionally diverse isoforms localized in different subcellular compartments","volume":"224","author":"Teixeira","year":"2006","journal-title":"Planta"},{"key":"2026101607222331100_kiag686-B38","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1105\/tpc.111.088443","article-title":"The Arabidopsis glucosyltransferase UGT76B1 conjugates isoleucic acid and modulates plant defense and senescence","volume":"23","author":"von Saint Paul","year":"2011","journal-title":"Plant Cell"},{"key":"2026101607222331100_kiag686-B39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116203","article-title":"Local and systemic response to heterogeneous sulfate resupply after sulfur deficiency in rice","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026101607222331100_kiag686-B40","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1093\/plphys\/kiac196","article-title":"Rice CIRCADIAN CLOCK ASSOCIATED 1 transcriptionally regulates ABA signaling to confer multiple abiotic stress tolerance","volume":"190","author":"Wei","year":"2022","journal-title":"Plant Physiol"},{"key":"2026101607222331100_kiag686-B41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00299-008-0614-x","article-title":"Enhanced heat and drought tolerance in transgenic rice seedlings overexpressing OsWRKY11 under the control of HSP101 promoter","volume":"28","author":"Wu","year":"2009","journal-title":"Plant Cell Rep."},{"key":"2026101607222331100_kiag686-B42","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/jipb.13869","article-title":"Diverse roles of MYB transcription factors in plants","volume":"67","author":"Zhang","year":"2025","journal-title":"J Integr Plant Biol"},{"key":"2026101607222331100_kiag686-B43","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.devcel.2020.10.012","article-title":"Thriving under stress: how plants balance growth and the stress response","volume":"55","author":"Zhang","year":"2020","journal-title":"Dev Cell"},{"key":"2026101607222331100_kiag686-B44","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1126\/science.abo5721","article-title":"A genetic module at one locus in rice protects chloroplasts to enhance thermotolerance","volume":"376","author":"Zhang","year":"2022","journal-title":"Science"},{"key":"2026101607222331100_kiag686-B45","doi-asserted-by":"publisher","first-page":"9326","DOI":"10.1073\/pnas.1701762114","article-title":"Temperature increase reduces global yields of major crops in four independent estimates","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026101607222331100_kiag686-B46","doi-asserted-by":"publisher","DOI":"10.3390\/plants14121784","article-title":"Identification and expression analysis of rice MYB family members in response to heat stress","volume":"14","author":"Zhao","year":"2025","journal-title":"Plants (Basel)"},{"key":"2026101607222331100_kiag686-B47","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.17252","article-title":"Rice glycosyltransferase UGT706F1 functions in heat tolerance through glycosylating flavonoids under the regulation of transcription factor MYB61","volume":"121","author":"Zhao","year":"2025","journal-title":"Plant J."},{"key":"2026101607222331100_kiag686-B48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12284-016-0086-5","article-title":"The rice TCM5 gene encoding a novel Deg protease protein is essential for chloroplast development under high temperatures","volume":"9","author":"Zheng","year":"2016","journal-title":"Rice (N Y)"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/plphys\/advance-article-pdf\/doi\/10.1093\/plphys\/kiag686\/71090265\/kiag686.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/202\/2\/kiag686\/71090265\/kiag686.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/202\/2\/kiag686\/71090265\/kiag686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:22:34Z","timestamp":1792149754000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/doi\/10.1093\/plphys\/kiag686\/8796192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/plphys\/kiag686","relation":{},"ISSN":["0032-0889","1532-2548"],"issn-type":[{"value":"0032-0889","type":"print"},{"value":"1532-2548","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,15]]},"article-number":"kiag686"}}