{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:24:45Z","timestamp":1788992685515,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Support Foundation 2018 of the Juntendo Institute of Mental Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>The aims of the present study were to examine the effects of short-term music interventions among patients with fibromyalgia (FM) and to clarify the alterations in functional connectivity and persistent pain.<\/jats:p><\/jats:sec>Design<\/jats:title>Pilot study.<\/jats:p><\/jats:sec>Setting<\/jats:title>All participants were evaluated at Juntendo University from November 2017 to January 2019.<\/jats:p><\/jats:sec>Subjects<\/jats:title>We enrolled female patients who had been clinically diagnosed with FM (N\u2009=\u200923).<\/jats:p><\/jats:sec>Methods<\/jats:title>All participants listened to Mozart\u2019s Duo for Violin and Viola No. 1, K. 423, in a quiet room for 17\u2009minutes. We compared the degree of pain using resting-state functional magnetic resonance imaging and the numeric rating scale before and after listening to music.<\/jats:p><\/jats:sec>Results<\/jats:title>Pain scores were significantly reduced after listening to music. Further, we observed there was a significant difference in connectivity between the right insular cortex (IC) and posterior cingulate cortex (PCC)\/precuneus (PCu) before and after listening to music. We also found that the difference between the right IC-PCu connectivity and the difference in pain scores were significantly correlated.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We found that a short period of music intervention reduced chronic pain and altered functional IC\u2013default mode network connectivity. Furthermore, music potentially normalized the neural network via IC\u2013default mode network connectivity, yielding temporary pain relief in patients with FM. Further longitudinal studies with larger sample sizes are required to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnaa071","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T12:16:33Z","timestamp":1582028193000},"page":"1546-1552","source":"Crossref","is-referenced-by-count":31,"title":["Music Intervention Reduces Persistent Fibromyalgia Pain and Alters Functional Connectivity Between the Insula and Default Mode Network"],"prefix":"10.1093","volume":"21","author":[{"given":"Chie","family":"Usui","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Juntendo University Nerima Hospital, Tokyo, Japan"},{"name":"Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kirino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan"},{"name":"Juntendo Shizuoka Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Information and Communication Sciences, Sophia University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Inami","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Hatta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Juntendo University Nerima Hospital, Tokyo, Japan"},{"name":"Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Institute of Innovative Medical Science and Education, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusuki","family":"Nishioka","sequence":"additional","affiliation":[{"name":"National Graduate Institute for Policy Studies, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"issue":"6447","key":"2020081623465941000_pnaa071-B1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/365611a0","article-title":"Music and spatial task performance","volume":"365","author":"Rauscher","year":"1993","journal-title":"Nature"},{"issue":"10004","key":"2020081623465941000_pnaa071-B2","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(15)60169-6","article-title":"Music as an aid for postoperative recovery in adults: A systematic review and meta-analysis","volume":"386","author":"Hole","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"2020081623465941000_pnaa071-B3","first-page":"261","article-title":"Effectiveness of cognitive-behavioral program on pain and fear in school-aged children undergoing intravenous placement","volume":"11","author":"Hsieh","year":"2017","journal-title":"Asian Nurs Res (Korean Soc Nurs Sci)"},{"issue":"7","key":"2020081623465941000_pnaa071-B4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.36076\/ppj\/2017.7.597","article-title":"Music-induced analgesia in chronic pain conditions: A systematic review and meta-analysis","volume":"20","author":"Garza-Villarreal","year":"2017","journal-title":"Pain Physician"},{"issue":"5","key":"2020081623465941000_pnaa071-B5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res (Hoboken"},{"issue":"2","key":"2020081623465941000_pnaa071-B6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. 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