{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:01Z","timestamp":1792035541329,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic constriction injury (CCI) is a model of neuropathic pain induced by four loose ligatures around the sciatic nerve. This work aimed to investigate the sensory, affective, cognitive, and motor changes induced by an adaptation of the CCI model by applying a single ligature around the sciatic nerve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mechanical allodynia was measured from day 1 to day 28 postsurgery by the von Frey test. The beam walking test (BWT) was conducted weekly until 28\u2009days after surgery.\u00a0Anxiety- and depression-like behaviors, and cognitive performance were assessed through the open field (OF), forced swimming (FS), and novel object recognition (NOR) tests, respectively, 21\u2009days after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The two CCI models, both Bennett and Xie\u2019s model (four ligatures of the sciatic nerve) and a modification of it (one ligature), induced mechanical allodynia, increased immobility in the FS, and reduced recognition index in the NOR. The exploratory behavior and time spent in the central part of the arena decreased, while the defensive behavior increased in the OF. The animals subjected to the two CCI models showed motor alterations in the BWT; however, autotomy was observed only in the group with four ligatures and not in the group with a single ligature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall these results demonstrate that our adapted CCI model, using a single ligature around the sciatic nerve, induces sensory, affective, cognitive, and motor alterations comparable to the CCI model with four ligatures without generating autotomy. This adaptation to the CCI model may therefore represent an appropriate and more easily performed model for inducing neuropathic pain and study underlying mechanisms and effective treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnaa206","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T07:09:03Z","timestamp":1590995343000},"page":"338-351","source":"Crossref","is-referenced-by-count":50,"title":["An Adapted Chronic Constriction Injury of the Sciatic Nerve Produces Sensory, Affective, and Cognitive Impairments: A Peripheral Mononeuropathy Model for the Study of Comorbid Neuropsychiatric Disorders Associated with Neuropathic Pain in Rats"],"prefix":"10.1093","volume":"22","author":[{"given":"Priscila","family":"Medeiros","sequence":"first","affiliation":[{"name":"Laboratory of Neurosciences of Pain & Emotions and Neuroelectrophysiology Multi-User Centre, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieda Regina","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivair Matias","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatric Surgery, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Palazzo","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Experimental Medicine, University of Campania \u201cL. Vanvitelli,\u201d Naples,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Aparecido","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Department of Psychology, Ribeir\u00e3o Preto School of Philosophy, Sciences and Literature of the University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Psychology Department, Federal University of Juiz de Fora (UFJF-MG) , Juiz de Fora, Minas Gerais,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Rubens","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences of Pain & Emotions and Neuroelectrophysiology Multi-User Centre, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Laboratory of Pediatric Surgery, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Henrique","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences of Pain & Emotions and Neuroelectrophysiology Multi-User Centre, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Biomedical Sciences Institute, Federal University of Alfenas (UNIFAL-MG), Str. Gabriel Monteiro da Silva , Alfenas, Minas Gerais,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabatino","family":"Maione","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Experimental Medicine, University of Campania \u201cL. Vanvitelli,\u201d Naples,","place":["Italy"]},{"name":"IRCCS Neuromed , 86077, Pozzilli-Caserta,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto Cysne","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences of Pain & Emotions and Neuroelectrophysiology Multi-User Centre, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-5326","authenticated-orcid":false,"given":"Renato Leonardo","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences of Pain & Emotions and Neuroelectrophysiology Multi-User Centre, Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP) , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Department of Psychology, Ribeir\u00e3o Preto School of Philosophy, Sciences and Literature of the University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo,","place":["Brazil"]},{"name":"Biomedical Sciences Institute, Federal University of Alfenas (UNIFAL-MG), Str. Gabriel Monteiro da Silva , Alfenas, Minas Gerais,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"2026041420165280600_pnaa206-B1","doi-asserted-by":"crossref","first-page":"e106907","DOI":"10.1371\/journal.pone.0106907","article-title":"The association of depression and anxiety with pain: A study from NESDA","volume":"9","author":"Heer","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"2026041420165280600_pnaa206-B2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jpain.2014.10.002","article-title":"The associations between preexisting mental disorders and subsequent onset of chronic headaches: A worldwide epidemiologic perspective","volume":"16","author":"Bruffaerts","year":"2015","journal-title":"J Pain"},{"issue":"20","key":"2026041420165280600_pnaa206-B3","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1001\/archinte.163.20.2433","article-title":"Depression and pain comorbidity: A literature review","volume":"163","author":"Bair","year":"2003","journal-title":"Arch Intern Med"},{"key":"2026041420165280600_pnaa206-B4","first-page":"12","article-title":"The link between depression and physical symptoms","volume":"6(Suppl 1","author":"Madhukar","year":"2004","journal-title":"Prim Care Companion J Clin Psychiatry"},{"issue":"1","key":"2026041420165280600_pnaa206-B5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/archpsyc.60.1.39","article-title":"Using chronic pain to predict depressive morbidity in the general population","volume":"60","author":"Ohayon","year":"2003","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"2026041420165280600_pnaa206-B6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1522-7154(1996)2:1<28::AID-ANXI4>3.0.CO;2-9","article-title":"Social, blood\/injury, and agoraphobic fears in patients with physically unexplained chronic pain: Are they clinically significant?","volume":"2","author":"Asmundson","year":"1996","journal-title":"Anxiety"},{"issue":"1","key":"2026041420165280600_pnaa206-B7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.genhosppsych.2011.09.004","article-title":"Psychiatric disorders as assessed with SCID in chronic pain patients: The anxiety disorders precede the onset of pain","volume":"34","author":"Knaster","year":"2012","journal-title":"Gen Hosp Psychiatry"},{"issue":"1","key":"2026041420165280600_pnaa206-B8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"issue":"2","key":"2026041420165280600_pnaa206-B9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0304-3959(90)90022-6","article-title":"Further evidence for pain-related behaviours in a model of unilateral peripheral mononeuropathy","volume":"41","author":"Attal","year":"1990","journal-title":"Pain"},{"issue":"2","key":"2026041420165280600_pnaa206-B10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"issue":"2","key":"2026041420165280600_pnaa206-B11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.14245\/ns.1836080.040","article-title":"Effective parameters for gait analysis in experimental models for evaluating peripheral nerve injuries in rats","volume":"16","author":"Matias J\u00fanior","year":"2019","journal-title":"Neurospine"},{"key":"2026041420165280600_pnaa206-B12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2014.08.051","article-title":"Motoneuron regeneration accuracy and recovery of gait after femoral nerve injuries in rats","volume":"280","author":"Kruspe","year":"2014","journal-title":"Neuroscience"},{"key":"2026041420165280600_pnaa206-B13","first-page":"739","volume-title":"Handbook of Molecular Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences)","author":"Belzung","year":"1999"},{"issue":"12","key":"2026041420165280600_pnaa206-B14","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/0269881113493363","article-title":"The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae)","volume":"27","author":"Twardowschy","year":"2013","journal-title":"J Psychopharmacol"},{"issue":"3","key":"2026041420165280600_pnaa206-B15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","article-title":"\u201cBehavioural despair\u201d in rats and mice: Strain differences and the effects of imipramine","volume":"51","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"2026041420165280600_pnaa206-B16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.pain.2009.02.018","article-title":"Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833","volume":"143","author":"Hu","year":"2009","journal-title":"Pain"},{"issue":"6","key":"2026041420165280600_pnaa206-B17","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1093\/cercor\/bht001","article-title":"NMDA and AMPA\/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus","volume":"24","author":"de Freitas","year":"2014","journal-title":"Cereb Cortex"},{"issue":"12","key":"2026041420165280600_pnaa206-B18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/syn.21926","article-title":"\u00b51-opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post-ictal antinociception","volume":"70","author":"de Freitas","year":"2016","journal-title":"Synapse"},{"key":"2026041420165280600_pnaa206-B19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuroscience.2016.08.040","article-title":"The \u03bc1-Opioid receptor and 5-HT2A- and 5HT2C-serotonergic receptors of the locus coeruleus are critical in elaborating hypoalgesia induced by tonic and tonic-clonic seizures","volume":"336","author":"de Freitas","year":"2016","journal-title":"Neuroscience"},{"issue":"8","key":"2026041420165280600_pnaa206-B20","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1017\/S1461145713000163","article-title":"Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: Role of the endocannabinoid CB1 receptor","volume":"16","author":"de Freitas","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"2026041420165280600_pnaa206-B21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainres.2009.09.096","article-title":"GABA(A) receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced antinociception","volume":"1305","author":"Freitas","year":"2009","journal-title":"Brain Res"},{"issue":"4","key":"2026041420165280600_pnaa206-B22","first-page":"197","article-title":"New frontiers in mechanisms and therapy of painful peripheral neuropathies","volume":"37","author":"Bennett","year":"1999","journal-title":"Acta Anaesthesiol Sin"},{"key":"2026041420165280600_pnaa206-B23","first-page":"461","volume-title":"The Management of Pain","author":"Chapman","year":"1990","edition":"2nd ed"},{"issue":"1\u20133","key":"2026041420165280600_pnaa206-B24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(01)01303-6","article-title":"Pathobiology of neuropathic pain","volume":"429","author":"Zimmermann","year":"2001","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2026041420165280600_pnaa206-B25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1053\/eujp.2001.0260","article-title":"A comparison of the SF-36 and Nottingham Health Profile in patients with chronic neuropathic pain","volume":"5","author":"Meyer-Rosberg","year":"2001","journal-title":"Eur J Pain"},{"issue":"2","key":"2026041420165280600_pnaa206-B26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0304-3959(79)90120-9","article-title":"Experimental pain in man","volume":"6","author":"Procacci","year":"1979","journal-title":"Pain"},{"issue":"4","key":"2026041420165280600_pnaa206-B27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.7326\/0003-4819-93-4-588","article-title":"The chronic pain syndrome: Misconceptions and management","volume":"93","author":"Reuler","year":"1980","journal-title":"Ann Intern Med"},{"key":"2026041420165280600_pnaa206-B28","first-page":"229","volume-title":"The Management of Pain","author":"Turner","year":"1990","edition":"2nd ed"},{"issue":"3","key":"2026041420165280600_pnaa206-B29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/1414-431X20122462","article-title":"An improved experimental model for peripheral neuropathy in rats","volume":"46","author":"Dias","year":"2013","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"2026041420165280600_pnaa206-B30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"issue":"21","key":"2026041420165280600_pnaa206-B31","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1242\/jeb.033886","article-title":"Whole limb kinematics are preferentially conserved over individual joint kinematics after peripheral nerve injury","volume":"212","author":"Chang","year":"2009","journal-title":"J Exp Biol"},{"issue":"2","key":"2026041420165280600_pnaa206-B32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bbr.2012.01.040","article-title":"The biomechanics of locomotor compensation after peripheral nerve lesion in the rat","volume":"229","author":"Bennett","year":"2012","journal-title":"Behav Brain Res"},{"issue":"1\u20133","key":"2026041420165280600_pnaa206-B33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effect of drugs on anxiety-like behaviors: A review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur J Pharmacol"},{"issue":"6\u20137","key":"2026041420165280600_pnaa206-B34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav Pharmacol"},{"issue":"6","key":"2026041420165280600_pnaa206-B35","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/j.pain.0000000000000150","article-title":"MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice","volume":"156","author":"Palazzo","year":"2015","journal-title":"Pain"},{"issue":"2","key":"2026041420165280600_pnaa206-B36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00002508-200006000-00004","article-title":"Negative affect, self-report of depressive symptoms, and clinical depression: Relation to the experience of chronic pain","volume":"16","author":"Geisser","year":"2000","journal-title":"Clin J Pain"},{"issue":"2","key":"2026041420165280600_pnaa206-B37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/jnr.24501","article-title":"Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice","volume":"98","author":"Medeiros","year":"2020","journal-title":"J Neurosci Res"},{"issue":"5","key":"2026041420165280600_pnaa206-B38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ejpain.2007.10.002","article-title":"Sciatic nerve cuffing in mice: A model of sustained neuropathic pain","volume":"12","author":"Benbouzid","year":"2008","journal-title":"Eur J Pain"},{"issue":"7","key":"2026041420165280600_pnaa206-B39","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00726-016-2205-4","article-title":"Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice","volume":"48","author":"Palazzo","year":"2016","journal-title":"Amino Acids"},{"issue":"9186","key":"2026041420165280600_pnaa206-B40","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/S0140-6736(99)03057-3","article-title":"The epidemiology of chronic pain in the community","volume":"354","author":"Elliott","year":"1999","journal-title":"Lancet"},{"issue":"4","key":"2026041420165280600_pnaa206-B41","first-page":"1","article-title":"Cognitive impairment in chronic pain","volume":"15","author":"Kreitler","year":"2007","journal-title":"Pain"},{"issue":"4","key":"2026041420165280600_pnaa206-B42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tins.2008.01.003","article-title":"Cortical excitation and chronic pain","volume":"31","author":"Zhuo","year":"2008","journal-title":"Trends Neurosci"},{"key":"2026041420165280600_pnaa206-B43","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.neuroimage.2014.01.020","article-title":"NeuroImage metabolic brain activity suggestive of persistent pain in a rat model of neuropathic pain","volume":"91","author":"Thompson","year":"2014","journal-title":"Neuroimage"},{"key":"2026041420165280600_pnaa206-B44","doi-asserted-by":"crossref","first-page":"9743","DOI":"10.1038\/s41598-017-09991-8","article-title":"Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats","volume":"7","author":"Chung","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"2026041420165280600_pnaa206-B45","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1007\/s11064-019-02843-z","article-title":"N-methyl-D-aspartate receptors in the prelimbic cortex are critical for the maintenance of neuropathic pain","volume":"44","author":"Medeiros","year":"2019","journal-title":"Neurochem Res"},{"issue":"46","key":"2026041420165280600_pnaa206-B46","doi-asserted-by":"crossref","first-page":"10410","DOI":"10.1523\/JNEUROSCI.2541-04.2004","article-title":"Chronic back pain is associated with decreased prefrontal and thalamic gray matter density","volume":"24","author":"Apkarian","year":"2004","journal-title":"J Neurosci"},{"issue":"1","key":"2026041420165280600_pnaa206-B47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1756-6606-5-36","article-title":"Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics","volume":"5","author":"Ji","year":"2012","journal-title":"Mol Brain"}],"container-title":["Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/painmedicine\/article-pdf\/22\/2\/338\/36347897\/pnaa206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/painmedicine\/article-pdf\/22\/2\/338\/36347897\/pnaa206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:30:45Z","timestamp":1776213045000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/painmedicine\/article\/22\/2\/338\/5900445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,9,2]]},"published-print":{"date-parts":[[2021,2,23]]}},"URL":"https:\/\/doi.org\/10.1093\/pm\/pnaa206","relation":{},"ISSN":["1526-2375","1526-4637"],"issn-type":[{"value":"1526-2375","type":"print"},{"value":"1526-4637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2020,9,2]]}}}