{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:28:13Z","timestamp":1773916093979,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974574"],"award-info":[{"award-number":["81974574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873314"],"award-info":[{"award-number":["81873314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Scientific Research Platforms and Research Projects of Universities in Guangdong Province","award":["2018KQNCX041"],"award-info":[{"award-number":["2018KQNCX041"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M633036"],"award-info":[{"award-number":["2018M633036"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of State Administration of Traditional Chinese Medicine of China","award":["20201129"],"award-info":[{"award-number":["20201129"]}]},{"name":"Medical Science Research Foundation of Guangdong Province","award":["A2020105"],"award-info":[{"award-number":["A2020105"]}]},{"name":"Medical Science Research Foundation of Guangdong Province","award":["B2019091"],"award-info":[{"award-number":["B2019091"]}]},{"name":"Project of Guangdong Provincial Department of Finance","award":["[2018]8"],"award-info":[{"award-number":["[2018]8"]}]},{"name":"Project of Guangdong Provincial Department of Finance","award":["[2014]157"],"award-info":[{"award-number":["[2014]157"]}]},{"name":"Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine","award":["YN2019ML08"],"award-info":[{"award-number":["YN2019ML08"]}]},{"name":"Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine","award":["YN2015MS15"],"award-info":[{"award-number":["YN2015MS15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the efficacy and safety of celecoxib and diclofenac sodium in patients with knee osteoarthritis (KOA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical controlled trials (CCTs) and randomized controlled trials (RCTs) from online databases comparing the efficacy of celecoxib and diclofenac sodium in the treatment of KOA were retrieved. The main outcomes included the treatment effect, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), visual analog scale (VAS) score, and complication rate. The Cochrane risk of bias (ROB) tool in Review Manager 5.3.5 was used to assess methodological quality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twelve studies (N\u2009=\u20092,350) were included in this meta-analysis. The meta-analysis indicated that celecoxib reduced pain more effectively than diclofenac sodium in patients with KOA, as evaluated by the VAS score. In addition, celecoxib has certain advantages in terms of better treatment effects and greater reductions in the ESR, CRP level, and complication rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Celecoxib is superior to diclofenac sodium in the treatment of KOA. However, well-designed and high-quality RCTs are still needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnaa230","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T11:12:35Z","timestamp":1591701155000},"page":"352-362","source":"Crossref","is-referenced-by-count":23,"title":["Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6197-1375","authenticated-orcid":false,"given":"Hetao","family":"Huang","sequence":"first","affiliation":[{"name":"Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese 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