{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:41:51Z","timestamp":1783388511930,"version":"3.54.6"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Epimed International"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Compare the effectiveness of catheter-directed cervical interlaminar epidural steroid injection (C-CIESI) with triamcinolone to cervical transforaminal steroid injection (CTFESI) with dexamethasone for the treatment of refractory unilateral radicular pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective, randomized, comparative trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Primary outcome: proportion of participants with \u226550% numeric rating scale pain score reduction from baseline \u201cdominant pain\u201d (the greater of arm vs neck) at one month postinjection. Secondary outcomes: \u226530% Neck Disability Index (NDI-5) reduction and Patient Global Impression of Change (PGIC) response indicating \u201cmuch improved\u201d or \u201cvery much improved.\u201d<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred twenty participants (55.6% females, 52.3\u2009\u00b1\u200912.5\u2009years of age, BMI 28.2\u2009\u00b1\u20096.5\u2009kg\/m2), were enrolled. The proportions of participants who experienced \u226550% pain reduction at one, three, and six months were 68.5% (95% CI = 54.9\u201379.5%), 59.3% (95% CI = 45.7\u201371.6%), and 60.8% (95% CI = 46.7\u201373.2%), respectively, in the C-CIESI group compared with 49.1% (95% CI = 36.4\u201362.0%), 46.4% (95% CI = 33.8\u201359.6%), and 51.9% (95% CI = 38.4\u201365.2%), respectively, in the CTFESI group. The between-group difference at one month was significant (P\u2009=\u20090.038). The proportions of participants who experienced a \u226530% NDI-5 score improvement were 64.0% (95% CI = 49.8\u201376.1%) and 54.9% (95% CI = 41.1\u201368.0%) in the C-CIESI and CTFESI groups (P\u2009=\u20090.352). Participants reported similar PGIC improvement in both groups: At six months, 53.2% (95% CI 38.9\u201367.1%) and 54.5% (95% CI = 39.7\u201368.7%) of the C-CIESI and CTFESI groups reported being \u201cmuch improved\u201d or \u201cvery much improved,\u201d respectively (P\u2009=\u20090.897).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both C-CIESI with triamcinolone and CTFESI with dexamethasone are effective in reducing pain and disability associated with refractory unilateral cervical radiculopathy in a substantial proportion of participants for at least six months.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnaa242","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T19:18:05Z","timestamp":1592939885000},"page":"2077-2089","source":"Crossref","is-referenced-by-count":14,"title":["A Randomized Comparative Trial of Targeted Steroid Injection via Epidural Catheter vs Standard Transforaminal Epidural Injection for the Treatment of Unilateral Cervical Radicular Pain: Six-Month Results"],"prefix":"10.1093","volume":"21","author":[{"given":"Zachary L","family":"McCormick","sequence":"first","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Conger","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau P","family":"Sperry","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Petersen","sequence":"additional","affiliation":[{"name":"Alabama College of Osteopathic Medicine, Dothan, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Salazar","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shellie","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Michael Henrie","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Bisson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kendall","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"issue":"2","key":"2021052608564685700_pnaa242-B1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/brain\/117.2.325","article-title":"Epidemiology of cervical radiculopathy. 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