{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:54:41Z","timestamp":1747270481134,"version":"3.37.3"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science, and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Republic of Serbia","award":["III 41005"],"award-info":[{"award-number":["III 41005"]}]},{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Republic of Serbia","award":["175022"],"award-info":[{"award-number":["175022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Previous studies suggest that increased cerebrovascular reactivity might be a feature of patients who have migraine with aura (MwA). The correlation between the clinical presentation of migraine with aura and transcranial Doppler parameters remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The main aim of this study was to explore cerebral blood flow, vascular resistance, and cerebrovascular reactivity in women MwA. Also, the relationships between hemodynamic conditions and aura characteristics are examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Headache Center, Neurology Clinic, Clinical Center of Serbia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>Fifty-four women MwA and 49 healthy controls (HCs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Transcranial Doppler sonography examination was used to determine blood flow mean velocity (MV) and pulsatility index (PI), as well as breath-holding index (BHI), in 15 arterial segments comprising the circle of Willis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 54 women MwA and 49 HCs were studied. The PIs of all segments of the left and right middle cerebral arteries and the left and right anterior cerebral arteries were significantly higher in MwA with regards to HCs. Also, both the left and right BHIs were significantly higher in MwA than HCs. In addition, MVs of the right vertebral artery and the first segment of the basilar artery were significantly lower in MwA than HCs. Longer duration of migraine aura showed a weak negative correlation with the PI of the left posterior cerebral artery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings suggest increased vessel pulsatility, abnormal cerebrovascular reactivity, and decreased cerebral blood flow velocity in several arterial segments of the Willis circle in women MwA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnaa292","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T04:29:19Z","timestamp":1595651359000},"page":"3012-3017","source":"Crossref","is-referenced-by-count":3,"title":["Transcranial Doppler Evaluation of the Cerebral Vasculature in Women Patients who Have Migraine with Aura"],"prefix":"10.1093","volume":"21","author":[{"given":"Igor","family":"Petru\u0161i\u0107","sequence":"first","affiliation":[{"name":"Laboratory for Advanced Analysis of Neuroimages, Faculty of Physical Chemistry, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Podgorac","sequence":"additional","affiliation":[{"name":"Institute of Mental Health, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Radoji\u010di\u0107","sequence":"additional","affiliation":[{"name":"Headache Center, Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasna","family":"Zidverc-Trajkovi\u0107","sequence":"additional","affiliation":[{"name":"Headache Center, Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"issue":"17","key":"2020112415470337700_pnaa292-B1","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","article-title":"Migraine: Multiple processes, complex pathophysiology","volume":"35","author":"Burstein","year":"2015","journal-title":"J Neurosci"},{"key":"2020112415470337700_pnaa292-B2","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/574186","article-title":"Is there a persistent dysfunction of neurovascular coupling in migraine?","volume":"2015","author":"Fabjan","year":"2015","journal-title":"Biomed Res Int"},{"issue":"12","key":"2020112415470337700_pnaa292-B3","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1468-2982.2007.01500.x","article-title":"Is the cerebral cortex hyperexcitable or hyperresponsive in migraine?","volume":"27","author":"Coppola","year":"2007","journal-title":"Cephalalgia"},{"key":"2020112415470337700_pnaa292-B4","doi-asserted-by":"crossref","first-page":"1039.","DOI":"10.3389\/fneur.2019.01039","article-title":"Altered resting state functional activity and microstructure of the white matter in migraine with aura","volume":"10","author":"Farag\u00f3","year":"2019","journal-title":"Front Neurol"},{"issue":"2","key":"2020112415470337700_pnaa292-B5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5853\/jos.2015.01683","article-title":"The migraine\u2013stroke connection","volume":"18","author":"Lee","year":"2016","journal-title":"J Stroke"},{"issue":"5","key":"2020112415470337700_pnaa292-B6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1468-2982.2001.00219.x","article-title":"Altered cerebrovascular response pattern in interictal migraine during visual stimulation","volume":"21","author":"B\u00e4cker","year":"2001","journal-title":"Cephalalgia"},{"issue":"8","key":"2020112415470337700_pnaa292-B7","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/head.12150","article-title":"Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: Results of the American Migraine Prevalence and Prevention (AMPP) study","volume":"53","author":"Buse","year":"2013","journal-title":"Headache"},{"issue":"9","key":"2020112415470337700_pnaa292-B8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0333102414559735","article-title":"Gender influences headache characteristics with increasing age in migraine patients","volume":"35","author":"Bolay","year":"2015","journal-title":"Cephalalgia"},{"issue":"8","key":"2020112415470337700_pnaa292-B9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1089\/jwh.2018.7274","article-title":"Sex and gender differences in migraine - 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