{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:30:23Z","timestamp":1776882623236,"version":"3.51.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Baudax Bio"},{"name":"Recro Pharma, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of perioperative meloxicam IV 30\u2009mg on opioid consumption in primary total knee arthroplasty (TKA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multicenter, randomized, double-blind, placebo-controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>In total, 181 adults undergoing elective primary TKA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects received meloxicam 30\u2009mg or placebo via an IV bolus every 24\u2009hours, the first dose administered prior to surgery as part of a multimodal pain management protocol. The primary efficacy parameter was total opioid use from end of surgery through 24\u2009hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meloxicam IV was associated with less opioid use versus placebo during the 24\u2009hours after surgery (18.9\u2009\u00b1\u20091.32 vs 27.7\u2009\u00b1\u20091.37\u2009mg IV morphine equivalent dose; P\u2009&amp;lt;\u20090.001) and was superior to placebo on secondary endpoints, including summed pain intensity (first dose to 24\u2009hours postdosing, first dose to first assisted ambulation, and first dose to discharge) and opioid use (48\u201372\u2009hrs., 0\u201348\u2009hrs., 0\u201372\u2009hrs., hour 0 to end of treatment, and the first 24\u2009hours after discharge). Adverse events (AEs) were reported for 69.9% and 92.0% of the meloxicam IV and placebo groups, respectively; the most common AEs were nausea (40% vs. 59%), vomiting (16% vs 22%), hypotension (14% vs 15%), pruritus (15% vs 11%), and constipation (11% vs 13%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perioperative meloxicam IV 30\u2009mg as part of a multimodal analgesic regimen for elective primary TKA reduced opioid consumption in the 24-hour period after surgery versus placebo and was associated with a lower incidence of AEs typically associated with opioid use.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnab016","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T15:59:02Z","timestamp":1611417542000},"page":"1261-1271","source":"Crossref","is-referenced-by-count":16,"title":["Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial"],"prefix":"10.1093","volume":"22","author":[{"given":"Richard D","family":"Berkowitz","sequence":"first","affiliation":[{"name":"University Orthopedic and Joint Replacement Center, Tamarac, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Steinfeld","sequence":"additional","affiliation":[{"name":"Orthopaedic Center of Vero Beach, Vero Beach, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander P","family":"Sah","sequence":"additional","affiliation":[{"name":"Institute for Joint Restoration & Research, Fremont, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-3765","authenticated-orcid":false,"given":"Randall J","family":"Mack","sequence":"additional","affiliation":[{"name":"Baudax Bio\u00a0Inc., Malvern, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart W","family":"McCallum","sequence":"additional","affiliation":[{"name":"Baudax Bio\u00a0Inc., Malvern, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Clinical Statistics Consulting, Blue Bell, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libby K","family":"Black","sequence":"additional","affiliation":[{"name":"Baudax Bio\u00a0Inc., Malvern, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Freyer","sequence":"additional","affiliation":[{"name":"Baudax Bio\u00a0Inc., Malvern, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Coyle","sequence":"additional","affiliation":[{"name":"Baudax Bio\u00a0Inc., Malvern, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"issue":"8","key":"2021061420181085800_pnab016-B1","doi-asserted-by":"crossref","first-page":"e368-73","DOI":"10.3928\/01477447-20110627-11","article-title":"A qualitative and quantitative needs assessment of pain management for hospitalized orthopedic patients","volume":"34","author":"Cordts","year":"2011","journal-title":"Orthopedics"},{"issue":"10","key":"2021061420181085800_pnab016-B2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1365-2044.2008.05565.x","article-title":"A procedure-specific systematic review and consensus recommendations for postoperative analgesia following total knee arthroplasty","volume":"63","author":"Fischer","year":"2008","journal-title":"Anaesthesia"},{"issue":"2","key":"2021061420181085800_pnab016-B3","first-page":"248","article-title":"American Society of Anesthesiologists Task Force on Acute Pain Management. 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