{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:23:16Z","timestamp":1770513796217,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The treatment for neuropathic pain is still a big challenge. Pulsed radiofrequency technique has been widely used to relieve neuropathic pain in recent years. The purpose of this study is to optimize the temperature for pulsed radiofrequency therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Animal, experimental study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventy-five male SD rats were randomly divided into five groups: Sham operation group (Sham group), chronic constriction injury group (CCI group), PRF 42\u00b0C group (P42 group), PRF 50\u00b0C group (P50 group), and PRF 60\u00b0C group (P60 group). The hindpaw withdrawal threshold (HWT), paw thermal withdrawal latency (PTWL), sciatic nerve structure, and the concentration of spinal methionine enkephalin(M-ENK) were detected to identify which temperature is the best for PRF treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>PRF at 42\u00b0C, 50\u00b0C and 60\u00b0C significantly alleviated the pain in CCI rats. The therapeutic effects of 50\u00b0C and 60\u00b0C were similar, and both were better than 42\u00b0C. In addition, PRF using 42\u00b0C, 50\u00b0C, and 60\u00b0C mediated nerve injury to sciatic nerve were grade 1, 1, and 2, respectively. The concentration of M-ENK in spinal cord increased accompanying with the increasing of the temperature of PRF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PRF using 50\u00b0C could induce less damage while achieving better improvement of mechanical and thermal pain threshold than 42\u00b0C and 60\u00b0C in CCI rats, which may be achieved by promoting the expression of M-ENK in spinal cord.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnab045","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T20:11:58Z","timestamp":1614024718000},"page":"1612-1618","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Pulsed Radiofrequency with Different Temperature on Model Rats of Chronic Constriction 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