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Furthermore, 70 healthy controls were included to establish normative values. Quantitative sensory testing (QST), including temporal summation of pain (TSP), conditioned pain modulation (CPM), and psychological and sleep variables, was assessed in a single session. TSP and CPM were then combined to build pain modulation profiles (PMP) for each individual.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference was found between groups for PMP, TSP, and CPM. However, 10 CTTH patients showed a pronociceptive PMP, with 8 related to a deficient CPM and 2 to both a deficient CPM and increased TSP. Increased cold detection thresholds were the most common sensory disturbance found in CTTH patients. Significant differences were seen between groups for pain catastrophizing, depression, and sleep quality although not all patient\u2019s scores were above the clinically meaningful cutoffs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, CTTH patients presented with different PMP. These PMP may be related to increased TSP, deficient CPM, alterations in thermal detection that may be related to autonomic dysregulation, or a combination of all three. Overall, this suggests that due to their heterogeneous pathophysiology, CTTH patients should be managed according to their underlying pathophysiology and not with a one-size-fits-all approach.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnab084","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T20:12:10Z","timestamp":1614715930000},"page":"2356-2365","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of Pain Modulatory and Somatosensory Profiles in Chronic Tension-Type Headache Patients"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-4072","authenticated-orcid":false,"given":"Fernando G","family":"Exposto","sequence":"first","affiliation":[{"name":"Section of Orofacial Pain and Jaw Function, Department of Dentistry, Aarhus University, Aarhus, Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON), Aarhus, 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