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Current evidence does not provide guidance for inpatient management of acute pain in adults with sickle cell disease. We conducted a retrospective analysis of a longitudinal cohort quality improvement project to characterize the role of individualized care plans on improving patient care and reducing financial burden in high healthcare-utilizing patients with SCD-related pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individualized care plans were developed for patients with hospital admissions resulting from pain associated with sickle cell disease. A 2-year prospective longitudinal cohort quality improvement project was performed and retrospectively analyzed. Primary outcome measure was duration of hospitalization. Secondary outcome measures included: pain intensity; 7, 30, and 90-day readmission rates; cost per day; total admissions; total cost per year; analgesic regimen at index admission; and discharge disposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Duration of hospitalization, the primary outcome, significantly decreased by 1.23\u2009days with no worsening of pain intensity scores. Seven-day readmission decreased by 34%. Use of intravenous hydromorphone significantly decreased by 25%. The potential cost saving was $1,398,827 as a result of this quality initiative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implementation of individualized care plans reduced both admission rate and financial burden of high utilizing patients. Importantly, pain outcomes were not diminished. Results suggest that individualized care plans are a promising strategy for managing acute pain crisis in adult sickle cell patients from both care-focused and utilization outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnab092","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T04:17:56Z","timestamp":1614745076000},"page":"1743-1752","source":"Crossref","is-referenced-by-count":17,"title":["Implementation of Individualized Pain Care Plans Decreases Length of Stay and Hospital Admission Rates for High Utilizing Adults with Sickle Cell Disease"],"prefix":"10.1093","volume":"22","author":[{"given":"Jena L","family":"Welch-Coltrane","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Section of Pain Medicine, Wake Forest School of Medicine, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A","family":"Wachnik","sequence":"additional","affiliation":[{"name":"Department of 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