{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:19:42Z","timestamp":1772248782455,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Myth<\/jats:title>\n                  <jats:p>Corticosteroid injection for the treatment of pain is known to decrease the efficacy of the adenovirus vector-based vaccines for COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Fact<\/jats:title>\n                  <jats:p>There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an adenovirus vector-based COVID-19 vaccine decreases the efficacy of the vaccine. However, based on the known timeline of hypothalamic-pituitary-adrenal axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Janssen and AstraZeneca vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to and no less than 2 weeks following a COVID-19 adenovirus vector-based vaccine dose, whenever possible. We emphasize the importance of risk\/benefit analysis and shared decision making in determining the timing of corticosteroid injections for pain indications in relation to receipt of a COVID-19 vaccine given that patient-specific factors will vary.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnab130","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:47:40Z","timestamp":1617922060000},"page":"1441-1464","source":"Crossref","is-referenced-by-count":5,"title":["Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of Adenovirus Vector-Based COVID-19 Vaccines?"],"prefix":"10.1093","volume":"22","author":[{"given":"Haewon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, University of California, San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A","family":"Punt","sequence":"additional","affiliation":[{"name":"University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaymin","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan P","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Anesthesiology, Critical Care and Pain Medicine Service, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-1816","authenticated-orcid":false,"given":"Belinda","family":"Duszynski","sequence":"additional","affiliation":[{"name":"Spine Intervention Society, Hinsdale, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-8745","authenticated-orcid":false,"given":"Zachary L","family":"McCormick","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Spine Intervention Society\u2019s Patient Safety Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"2021070821110560400_pnab130-B1"},{"key":"2021070821110560400_pnab130-B2"},{"key":"2021070821110560400_pnab130-B3"},{"key":"2021070821110560400_pnab130-B4","year":"2021"},{"key":"2021070821110560400_pnab130-B5"},{"issue":"11","key":"2021070821110560400_pnab130-B6","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1099\/vir.0.19497-0","article-title":"Genetic content and evolution of adenoviruses","volume":"84","author":"Davison","year":"2003","journal-title":"J Gen Virol"},{"issue":"4","key":"2021070821110560400_pnab130-B7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ymthe.2004.07.013","article-title":"Adenoviruses as vaccine vectors","volume":"10","author":"Tatsis","year":"2004","journal-title":"Molecular Therapy"},{"key":"2021070821110560400_pnab130-B8"},{"key":"2021070821110560400_pnab130-B9"},{"key":"2021070821110560400_pnab130-B10","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2034201","article-title":"Interim results of a phase 1-2a trial of Ad26.COV2.S COVID-19 vaccine","author":"Sadoff","year":"2021","journal-title":"N Engl J Med"},{"issue":"2","key":"2021070821110560400_pnab130-B11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1378\/chest.110.2.367","article-title":"Serum antibody response to influenza vaccine in pulmonary patients receiving corticosteroids","volume":"110","author":"Kubiet","year":"1996","journal-title":"Chest"},{"issue":"1","key":"2021070821110560400_pnab130-B12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/jama.1979.03300010037025","article-title":"Influenza vaccination in patients with rheumatic diseases. 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