{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:19:56Z","timestamp":1782973196411,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCRD-TPE-104-22"],"award-info":[{"award-number":["TCRD-TPE-104-22"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To elucidate the effectiveness of ultrasound-guided genicular nerve radiofrequency ablation in alleviating pain as well as its effects on functional outcomes, quality of life and physical performance in knee osteoarthritis patients.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Patients were recruited within one community hospital.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Patients with knee osteoarthritis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The subjects underwent ultrasound-guided radiofrequency ablation of genicular nerves after showing a positive response to a diagnostic block. Outcome assessments were performed at baseline and at 2 and 12\u2009weeks posttreatments using the 36-item Short Form Health Survey (SF-36), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and a physical performance evaluation including balance tests, quadriceps muscle strength test, two-minute walking test and knee joint proprioception test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Thirteen out of 38 patients were eligible for genicular nerve radiofrequency ablation. There were significant improvements from baseline to posttreatment in the numeric rating scale score, physical health domain score of SF-36, and pain and stiffness domain scores of the WOMAC. Regarding physical performance, the step test result significantly improved over the 12\u2009weeks of follow-up. On the other hand, no significant deteriorations in the single leg stance test, isokinetic quadriceps muscle strength test, knee joint proprioception test or two-minute walking test results were observed after radiofrequency ablation of genicular nerves.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Radiofrequency ablation of genicular nerves may significantly alleviate pain and improve functional outcomes in knee osteoarthritis patients. More importantly, static balance control and quadriceps muscle strength were preserved and there was a change of proprioception in the good direction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/pm\/pnab280","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T19:24:45Z","timestamp":1631733885000},"page":"352-361","source":"Crossref","is-referenced-by-count":10,"title":["Functional Outcomes and Physical Performance of Knee Osteoarthritis Patients After Ultrasound-Guided Genicular Nerve Radiofrequency Ablation"],"prefix":"10.1093","volume":"23","author":[{"given":"Yi-Wei","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, School of Medicine, Tzu Chi University, Hualien, Taiwan"},{"name":"Graduate Institute of Injury Prevention and Control, College of Public 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