{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:53:38Z","timestamp":1784328818997,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MAU at the Institute of Neurological Sciences"},{"name":"German Pain Association"},{"name":"German Pain League"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the effectiveness of \u03949-tetrahydrocannabinol (dronabinol [DRO]) as an add-on treatment in patients with refractory chronic pain (CP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An exploratory retrospective analysis of 12-week data provided by the German Pain e-Registry on adult patients with treatment refractory CP who received DRO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between March 10, 2017, and June 30, 2019, the German Pain e-Registry collected information on 89,095 patients with pain, of whom 1,145 patients (1.3%) received DRO (53.8% female, mean\u2009\u00b1\u2009standard deviation age: 56.9\u2009\u00b1\u200910.6\u2009years), and 70.0% documented use for the entire 12-week evaluation period. The average DRO daily dose was 15.8\u2009\u00b1\u20097.5\u2009mg, typically in three divided doses (average DRO dose of 5.3\u2009\u00b1\u20092.1\u2009mg). Average 24-hour pain intensity decreased from 46.3\u2009\u00b1\u200916.1 to 26.8\u2009\u00b1\u200918.7\u2009mm on a visual analog scale (absolute visual analog scale difference: \u201319.5\u2009\u00b1\u200917.3; P\u2009&amp;lt;\u20090.001). Among patients who completed follow-up, an improvement from baseline of at least 50% was documented for pain (46.5%), activities of daily living (39%), quality of life (31.4%), and sleep (35.3%). A total of 536 patients (46.8%) reported at least one of 1,617 drug-related adverse events, none of which were serious, and 248 patients (21.7%) stopped treatment. Over the 12-week period, 59.0% of patients reported a reduction of other pain treatments, and 7.8% reported a complete cessation of any other pharmacological pain treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Add-on treatment with DRO in patients with refractory CP was well tolerated and associated with a significant improvement.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnac010","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T20:15:11Z","timestamp":1643314511000},"page":"1409-1422","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness and Tolerability of Dronabinol Use in Patients with Chronic Pain: A Retrospective Analysis of 12-Week Open-Label Real-World Data Provided by the German Pain e-Registry"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-9492","authenticated-orcid":false,"given":"Michael A","family":"Ueberall","sequence":"first","affiliation":[{"name":"Center of Excellence in Health Care Research of the German Pain Association, Institute of Neurological Sciences , Nuernberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Horlemann","sequence":"additional","affiliation":[{"name":"German Pain Association , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Schuermann","sequence":"additional","affiliation":[{"name":"Department for Pain and Palliative Care Medicine, St. Josef Hospital Moers , Moers, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-5197","authenticated-orcid":false,"given":"Maja","family":"Kalaba","sequence":"additional","affiliation":[{"name":"Canopy Growth Corporation , Smiths Falls, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Ware","sequence":"additional","affiliation":[{"name":"Canopy Growth Corporation , Smiths Falls, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"2022080109292253200_pnac010-B1","volume-title":"The Management of Pain","author":"Bonica","year":"1953"},{"key":"2022080109292253200_pnac010-B2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-12819-6_1","volume-title":"Praktische Schmerztherapie","author":"Treede","year":"2011"},{"key":"2022080109292253200_pnac010-B3","volume-title":"Classification of Chronic Pain","author":"Merskey","year":"1994","edition":"2nd edition."},{"issue":"4","key":"2022080109292253200_pnac010-B4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey 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