{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:29:48Z","timestamp":1788269388886,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-D-110117"],"award-info":[{"award-number":["TSGH-D-110117"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Interest in perineural platelet-rich-plasma (PRP) injections for the treatment of carpal tunnel syndrome (CTS) has increased in recent years. However, evidence supporting the long-term effectiveness of PRP is lacking. Therefore, the aim of our cross-sectional cohort study was to investigate the long-term results of PRP injections for CTS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eighty-one patients diagnosed with CTS of any grade who received a single PRP injection at least 2\u2009years prior were enrolled. Through structured telephone interviews, all patients were asked of their post-injection outcomes compared to their pre-injection condition. Symptom relief \u226550%, compared to the pre-injection condition, was considered an effective outcome. Binary logistic regression was applied to analyze each baseline variable as a regressor for determining the prognostic outcome factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 70% of patients reported positive outcomes \u22652\u2009years post-injection. Shorter duration of symptoms before treatment (odds ratio: 0.991; 95% confidence interval [CI] 0.983\u20130.999; P\u2009=\u2009.023) and lower electrodiagnostic severity of CTS were the main prognostic factors for an effective outcome (mild grade vs severe grade, odds ratio: 17.652; 95% CI 1.43\u2013221.1; P\u2009=\u2009.025). Although there was a trend toward positive outcomes at longer follow-up durations (2\u20133\u2009years vs 3\u20134\u2009years vs 4\u20135\u2009years), the difference was not statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A single perineural PRP injection has a long-term analgesic effect on CTS, especially in mild-to-moderate cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnac011","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T12:08:34Z","timestamp":1642248514000},"page":"1249-1258","source":"Crossref","is-referenced-by-count":17,"title":["The Long-Term Analgesic Effectiveness of Platelet-Rich Plasma Injection for Carpal Tunnel Syndrome: A Cross-Sectional Cohort Study"],"prefix":"10.1093","volume":"23","author":[{"given":"Chia-Ying","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"},{"name":"Integrated Pain Management Center, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-829X","authenticated-orcid":false,"given":"King Hei Stanley","family":"Lam","sequence":"additional","affiliation":[{"name":"The Hong Kong Institute of Musculoskeletal Medicine , Hong Kong"},{"name":"Department of Family Medicine, The Chinese University of Hong Kong , Hong Kong"},{"name":"Department of Family Medicine, The University of Hong Kong , Hong Kong"},{"name":"Center for Regional Anesthesia and Pain Medicine, Wan Fang Hospital, Taipei Medical University , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Public Health, National Defense Medical Center , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dueng-Yuan","family":"Hueng","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"},{"name":"Department of Biology and Anatomy, National Defense Medical Center , Taipei, Taiwan"},{"name":"Department of Biochemistry, National Defense Medical Center , Taipei, Taiwan"},{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-7909","authenticated-orcid":false,"given":"Yung-Tsan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"},{"name":"Integrated Pain Management Center, Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei, Taiwan"},{"name":"Department of Research and Development, School of Medicine, National Defense Medical Center , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"issue":"9","key":"2022070118364333100_pnac011-B1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S1388-2457(02)00169-4","article-title":"Carpal tunnel syndrome: Pathophysiology and clinical neurophysiology","volume":"113","author":"Werner","year":"2002","journal-title":"Clin Neurophysiol"},{"issue":"10","key":"2022070118364333100_pnac011-B2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11916-019-0811-z","article-title":"Recent advances in the understanding and management of carpal tunnel syndrome: A comprehensive review","volume":"23","author":"Urits","year":"2019","journal-title":"Curr Pain Headache Rep"},{"issue":"7","key":"2022070118364333100_pnac011-B3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.apmr.2010.03.022","article-title":"Carpal tunnel syndrome. 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