{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:31:38Z","timestamp":1778524298750,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Theranica Bio-Electronics Ltd"},{"DOI":"10.13039\/100000038","name":"Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003983","name":"National Headache Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003983","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005339","name":"American Academy of Neurology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005339","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association of American Physicians"},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Evidence indicates that combining behavioral treatments with pharmacological treatments for migraine prevention improves efficacy, but little is known about the outcomes of combining neuromodulation and behavioral interventions for acute treatment of migraine. Remote electrical neuromodulation (REN) is a U.S. Food and Drug Administration (FDA)\u2013cleared nonpharmacological migraine treatment. The present study evaluated the clinical benefits of augmenting REN treatment with a specially tailored behavioral therapy consisting of Guided Intervention of Education and Relaxation (GIER) for the acute treatment of migraine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this two-arm observational study, real-world data were collected from patients across the United States who were using the REN device. Eighty-five migraine patients \u226518 years of age who treated their attacks with REN in parallel with the GIER intervention were individually matched on age and sex with 85 patients who used REN alone. The groups were compared on the proportion of migraine attacks in which they achieved pain relief, pain freedom, improvement of function, and return to normal function, all at 2\u2009hours after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Data from 170 users were analyzed (85 per group). Compared with the REN-only group, the REN+GIER group displayed a statistically significant higher proportion of patients achieving consistent pain relief (P\u2009=\u20090.008), consistent improvement in function (P\u2009=\u20090.014), and consistent return to normal function (P\u2009=\u20090.005), all at 2\u2009hours after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results suggest that combining the GIER behavioral intervention with REN treatment can improve the therapeutic efficacy beyond that of REN alone, in terms of both pain level and improvement of disability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnac021","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T12:07:13Z","timestamp":1644149233000},"page":"1544-1549","source":"Crossref","is-referenced-by-count":13,"title":["Combining Guided Intervention of Education and Relaxation (GIER) with Remote Electrical Neuromodulation (REN) in the Acute Treatment of Migraine"],"prefix":"10.1093","volume":"23","author":[{"given":"Dawn C","family":"Buse","sequence":"first","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine , Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-5361","authenticated-orcid":false,"given":"Liron","family":"Rabany","sequence":"additional","affiliation":[{"name":"Theranica Bio-Electronics LTD. , Netanya, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Lin","sequence":"additional","affiliation":[{"name":"Theranica Bio-Electronics LTD. , Netanya, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Ironi","sequence":"additional","affiliation":[{"name":"Theranica Bio-Electronics LTD. , Netanya, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Connelly","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Health, Children's Mercy Kansas City and University of Missouri-Kansas City , Kansas City, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L","family":"Bickel","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Health, Children's Mercy Kansas City and University of Missouri-Kansas City , Kansas City, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"issue":"6","key":"2022090108151365000_pnac021-B1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1212\/WNL.55.6.754","article-title":"Practice parameter: Evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards 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