{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:23:28Z","timestamp":1791919408768,"version":"4.3.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"University of Rochester Departments of Neurosurgery, Anesthesiology and Perioperative Medicine"},{"name":"Biostatistics and Computational Biology"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Currently available treatments for neuropathic pain are only modestly efficacious when assessed in randomized clinical trials and work for only some patients in the clinic. Induced-pain or gain-of-function phenotypes have been shown to predict response to analgesics (vs placebos) in patients with neuropathic pain. However, the predictive value of these phenotypes has never been studied in post-traumatic neuropathic pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mixed-effects models for repeated measures were used to evaluate the efficacy of pregabalin vs placebo in subgroups with induced-pain phenotypes (i.e., hyperalgesia or allodynia) in data from a recent, multinational randomized clinical trial (N\u2009=\u2009539) that identified phenotypic subgroups through the use of a structured clinical exam.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The difference in mean pain score between the active and placebo groups (i.e., delta) after 15\u2009weeks of treatment for the subgroup with hyperalgesia was \u20130.76 (P\u2009=\u20090.001), compared with 0.19 (P\u2009=\u20090.47) for the subgroup that did not have hyperalgesia. The treatment-by-phenotype interaction, which tests whether subgroups have statistically different treatment responses, was significant (P\u2009=\u20090.0067). The delta for the subgroup with allodynia was \u20130.31 (P\u2009=\u20090.22), compared with \u20130.30 (P\u2009=\u20090.22) for the subgroup that did not have allodynia (treatment-by-phenotype interaction P\u2009=\u20090.98).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These data suggest that hyperalgesia, but not allodynia, predicts response to pregabalin in patients with chronic post-traumatic neuropathic pain. This study extends the growing data supporting the utility of induced-pain phenotypes to predict response to analgesics in post-traumatic neuropathic pain. Sensory phenotyping in large, multisite trials through the use of a structured clinical exam has the potential to accelerate the development of new analgesics and improve the generalizability of clinical trial results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnac045","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T04:10:30Z","timestamp":1647663030000},"page":"1726-1732","source":"Crossref","is-referenced-by-count":4,"title":["Predicting Treatment Response with Sensory Phenotyping in Post-Traumatic Neuropathic Pain"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7938-6775","authenticated-orcid":false,"given":"Jennifer S","family":"Gewandter","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester , Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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