{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:32:03Z","timestamp":1772155923313,"version":"3.50.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K22NS096030"],"award-info":[{"award-number":["K22NS096030"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Pain Society Future Leaders"},{"name":"Rita Allen Foundation Award in Pain"},{"name":"University of Texas System Rising STARS"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UM1 AR06338"],"award-info":[{"award-number":["UM1 AR06338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NIH UM1 AR06338-S1"],"award-info":[{"award-number":["NIH UM1 AR06338-S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["54TR001013"],"award-info":[{"award-number":["54TR001013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["NIH UL1TR000445"],"award-info":[{"award-number":["NIH UL1TR000445"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fibromyalgia (FM) is a chronic pain disorder characterized by chronic widespread musculoskeletal pain (CWP), resting pain, movement-evoked pain (MEP), and other somatic symptoms that interfere with daily functioning and quality of life. In clinical studies, this symptomology is assessed, while preclinical models of CWP are limited to nociceptive assays. The aim of the study was to investigate the human-to-model translatability of clinical behavioral assessments for spontaneous (or resting) pain and MEP in a preclinical model of CWP. For preclinical measures, the acidic saline model of FM was used to induce widespread muscle pain in adult female mice. Two intramuscular injections of acidic or neutral pH saline were administered following baseline measures, 5 days apart. An array of adapted evoked and spontaneous pain measures and functional assays were assessed for 3 weeks. A novel paradigm for MEP assessment showed increased spontaneous pain following activity. For clinical measures, resting and movement-evoked pain and function were assessed in adult women with FM. Moreover, we assessed correlations between the preclinical model of CWP and in women with fibromyalgia to examine whether similar relationships between pain assays that comprise resting and MEP existed in both settings. For both preclinical and clinical outcomes, MEP was significantly associated with mechanical pain sensitivity. Preclinically, it is imperative to expand how the field assesses spontaneous pain and MEP when studying multi-symptom disorders like FM. Targeted pain assessments to match those performed clinically is an important aspect of improving preclinical to clinical translatability of animal models.<\/jats:p>","DOI":"10.1093\/pm\/pnac047","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T16:13:11Z","timestamp":1648051991000},"page":"1690-1707","source":"Crossref","is-referenced-by-count":7,"title":["Translating Outcomes from the Clinical Setting to Preclinical Models: Chronic Pain and Functionality in Chronic Musculoskeletal Pain"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-4700","authenticated-orcid":false,"given":"Melissa E","family":"Lenert","sequence":"first","affiliation":[{"name":"Neuroimmunology and Behavior Laboratory, Department of Neuroscience, Center for Advanced Pain Studies (CAPS), School of Behavioral and Brain Sciences, University of Texas at Dallas , Richardson, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Gomez","sequence":"additional","affiliation":[{"name":"Inclusive and Translational Research in Pain Lab, Department of Physical Therapy, Steinhardt School of Culture, Education, and Human Development, New York University , New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon T","family":"Lane","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Behavior Laboratory, Department of Neuroscience, Center for Advanced Pain Studies (CAPS), School of Behavioral and Brain Sciences, University of Texas at Dallas , Richardson, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana L","family":"Dailey","sequence":"additional","affiliation":[{"name":"Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA"},{"name":"Department of Physical Therapy, Center for Health Sciences, St. Ambrose University , Davenport, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol G T","family":"Vance","sequence":"additional","affiliation":[{"name":"Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A","family":"Rakel","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Iowa , Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie J","family":"Crofford","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-8728","authenticated-orcid":false,"given":"Kathleen A","family":"Sluka","sequence":"additional","affiliation":[{"name":"Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka N","family":"Merriwether","sequence":"additional","affiliation":[{"name":"Inclusive and Translational Research in Pain Lab, Department of Physical Therapy, Steinhardt School of Culture, Education, and Human Development, New York University , New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-824X","authenticated-orcid":false,"given":"Michael D","family":"Burton","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Behavior Laboratory, Department of Neuroscience, Center for Advanced Pain Studies (CAPS), School of Behavioral and Brain Sciences, University of Texas at Dallas , Richardson, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"issue":"1","key":"2022100307580515000_pnac047-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-019-1976-2","article-title":"Animal to human translation: A systematic scoping review of reported concordance rates","volume":"17","author":"Leenaars","year":"2019","journal-title":"J Transl Med"},{"issue":"4","key":"2022100307580515000_pnac047-B2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: Progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"2022100307580515000_pnac047-B3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tips.2004.04.008","article-title":"Pain-like behaviours in animals \u2013 how human are 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