{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:14:50Z","timestamp":1791324890187,"version":"4.3.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"JSPS KAKENHI","award":["JP16K10306"],"award-info":[{"award-number":["JP16K10306"]}]},{"name":"JSPS KAKENHI","award":["JP16H06280"],"award-info":[{"award-number":["JP16H06280"]}]},{"name":"JSPS KAKENHI","award":["JP20K08099"],"award-info":[{"award-number":["JP20K08099"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the functional connectivity (FC) in patients with migraine compared with healthy subjects before and after C2 peripheral nerve field stimulation with electroacupuncture (EA-C2-PNfS) to evaluate the effect of EA-C2-PNfS and elucidate the mechanism of migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-six patients with migraine and 24 healthy controls were recruited. All patients underwent resting state functional magnetic resonance imaging before and after 3\u2009months of EA-C2-PNfS. We evaluated a numerical rating scale, the Headache Impact Test, and the Self-Rating Depression Scale, which assesses depression. Healthy controls underwent magnetic resonance imaging twice at a 3-month interval without acupuncture. An analysis of FC in the region of interest in the pain matrix was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients with migraine and 23 healthy controls (mean\u2009\u00b1\u2009standard deviation: 44.9\u2009\u00b1\u200912.9\u2009years of age) were included. Three patients had migraine with aura (55.0\u2009\u00b1\u200918.0\u2009years of age), 11 patients had migraine without aura (MWoA) (45.6\u2009\u00b1\u200914.6\u2009years of age), and six patients had chronic migraine (40.8\u2009\u00b1\u200913.9\u2009years of age). The clinical assessments significantly improved after EA-C2-PNfS in the MWoA group only. In FC analysis, the MWoA group showed a significant decrease after EA-C2-PNfS in FC between the right hypothalamus and left insula. Right hypothalamus\u2013related FC was lower before acupuncture in the chronic migraine group than in the MWoA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After EA-C2-PNfS for MWoA, significant changes in FC were observed at the hypothalamus and insula. Our results indicate that EA-C2-PNfS could improve migraine headache by modifying pain-related FC.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnac048","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T12:10:41Z","timestamp":1647691841000},"page":"1560-1569","source":"Crossref","is-referenced-by-count":15,"title":["The Modifying of Functional Connectivity Induced by Peripheral Nerve Field Stimulation\u00a0using Electroacupuncture for Migraine: A Prospective Clinical Study"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-6885","authenticated-orcid":false,"given":"Sumire","family":"Ishiyama","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Tsukuba University of Technology , Tsukuba, Ibaraki, Japan"},{"name":"Graduate School of Comprehensive Human Sciences, Doctoral Program in Clinical Sciences, University of Tsukuba , Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Headache Clinic, University of Tsukuba, Mito Medical Center, Mito Kyodo General Hospital , Mito, Ibaraki, Japan"},{"name":"Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ayuzawa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Tsukuba University of Technology , Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Neurorehabilitation, Ibaraki Prefectural University of Health Sciences , Ami, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"},{"name":"Ibaraki Prefectural University of Health Sciences , Ami, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"issue":"1","key":"2022090108152038700_pnac048-B1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1474-4422(14)70193-0","article-title":"Functional MRI of migraine","volume":"14","author":"Schwedt","year":"2015","journal-title":"Lancet 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