{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:28:35Z","timestamp":1793474915076,"version":"4.5.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the effects of pain neuroscience education (PNE) on patients with fibromyalgia in terms of pain intensity, fibromyalgia impact, anxiety, and pain catastrophizing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review with meta-analysis of randomized controlled trials was conducted. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated with RStudio software (RStudio, Boston, MA) for relevant outcomes and were pooled in a meta-analysis with the random effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of eight studies were included. The meta-analysis showed statistically significant differences in pain intensity with a moderate clinical effect in seven studies at the post-intervention assessment (SMD: \u20130.76; 95% CI: \u20131.33 to \u20130.19; P\u2009&amp;lt;\u20090.05) with evidence of significant heterogeneity (P\u2009&amp;lt;\u20090.05, I2\u2009=\u200992%), but it did not show statistically significant differences in fibromyalgia impact, anxiety, and pain catastrophizing (P\u2009&amp;gt;\u20090.05). With regard to the follow-up assessment, only the fibromyalgia impact showed significant improvements, with a very small clinical effect in nine studies (SMD: \u20130.44; 95% CI: \u20130.73 to \u20130.14; P\u2009&amp;lt;\u20090.05) and evidence of significant heterogeneity (P\u2009&amp;lt;\u20090.05, I2\u2009=\u200980%). After the application of a sensitivity analysis with the PNE face-to-face interventions, the meta-analysis showed a significant decrease in pain intensity, with a moderate clinical effect at the post-intervention and follow-up assessments without evidence of significant heterogeneity (P\u2009&amp;lt;\u20090.05, I2\u2009=\u200910%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is low-quality evidence that in patients with fibromyalgia, PNE can decrease the pain intensity in the post-intervention period and the fibromyalgia impact in the follow-up period. However, it appears that PNE showed no effect on anxiety and pain catastrophizing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnac077","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T08:17:19Z","timestamp":1652948239000},"page":"1837-1850","source":"Crossref","is-referenced-by-count":42,"title":["Effectiveness of Pain Neuroscience Education in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-4243","authenticated-orcid":false,"given":"Luis","family":"Suso-Mart\u00ed","sequence":"first","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4644-3758","authenticated-orcid":false,"given":"Ferran","family":"Cuenca-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Alba-Quesada","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Mu\u00f1oz-Alarcos","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Herranz-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-8013","authenticated-orcid":false,"given":"Clovis","family":"Varangot-Reille","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dom\u00ednguez-Navarro","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Casa\u00f1a","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"issue":"5","key":"2022110207583284600_pnac077-B1","doi-asserted-by":"crossref","first-page":"ITC33","DOI":"10.7326\/AITC202003030","article-title":"Fibromyalgia","volume":"172","author":"Bair","year":"2020","journal-title":"Ann Intern Med"},{"issue":"2","key":"2022110207583284600_pnac077-B2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12016-015-8509-4","article-title":"Fibromyalgia: A critical and comprehensive review","volume":"49","author":"Borchers","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"issue":"5","key":"2022110207583284600_pnac077-B3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.7748\/ns.2016.e10550","article-title":"Fibromyalgia: Clinical features, diagnosis and management","volume":"31","author":"Walker","year":"2016","journal-title":"Nurs Stand"},{"issue":"1","key":"2022110207583284600_pnac077-B4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.semarthrit.2014.01.001","article-title":"Central sensitization in fibromyalgia? 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