{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:36:46Z","timestamp":1790721406231,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Relievant Medsystems, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigate associations between endplate and motion segment magnetic resonance imaging (MRI) characteristics and treatment outcomes following basivertebral nerve radiofrequency ablation (BVN RFA) in patients with clinically suspected vertebral endplate pain (VEP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Aggregated cohort study of 296 participants treated with BVN RFA from three prospective clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline MRI characteristics were analyzed using stepwise logistic regression to identify factors associated with treatment success. Predictive models used three definitions of treatment success: (1) \u226550% low back pain (LBP) visual analog scale (VAS), (2) \u226515-point Oswestry Disability Index (ODI), and (3) \u226550% VAS or \u226515-point ODI improvements at 3-months post-BVN RFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of lumbar facet joint fluid (odds ratio [OR] 0.586) reduced the odds of BVN RFA treatment success in individuals with clinically suspected VEP. In patients with a less advanced degenerative disc disease (DDD) profile, a\u2009&amp;gt;\u200950% area of the endplate with bone marrow intensity changes (BMIC) was predictive of treatment success (OR 4.689). Both regressions areas under the curve (AUCs) were under 70%, indicating low predictive value. All other vertebral endplate, intervertebral disc, nerve roots facet joint, spinal segmental alignment, neuroforamina, lateral recesses, and central canal MRI characteristics were not associated with BVN RFA success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with vertebrogenic low back pain with Modic changes, the presence of degenerative findings of the anterior and posterior column was not associated with a clinically important impact on BVN RFA treatment success. None of the models demonstrated strong predictive value, indicating that the use of objective imaging biomarkers (Type 1 and\/or 2 Modic changes) and a correlating presentation of pain remain the most useful patient selection factors for BVN RFA.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnac093","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T09:15:02Z","timestamp":1658308502000},"page":"S34-S49","source":"Crossref","is-referenced-by-count":18,"title":["Magnetic Resonance Imaging Characteristics Associated with Treatment Success from Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trials Data"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-8745","authenticated-orcid":false,"given":"Zachary L","family":"McCormick","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine , Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Conger","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine , Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Smuck","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Stanford University , Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C","family":"Lotz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University of California San Francisco , San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colton","family":"Hickman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine , Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Harper","sequence":"additional","affiliation":[{"name":"Technomics Research LLC , Mi nneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-9695","authenticated-orcid":false,"given":"Taylor R","family":"Burnham","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine , Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"6","key":"2022072009143903600_pnac093-B1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/annrheumdis-2013-204428","article-title":"The global burden of low back pain: Estimates from the global burden of disease 2010 study","volume":"73","author":"Hoy","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2022072009143903600_pnac093-B2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.spinee.2007.10.005","article-title":"A systematic review of low back pain cost of illness studies in the United States and internationally","volume":"8","author":"Dagenais","year":"2008","journal-title":"Spine J"},{"issue":"2","key":"2022072009143903600_pnac093-B3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1526-4637.2010.01045.x","article-title":"What is the source of chronic low back pain and does age play a role?","volume":"12","author":"DePalma","year":"2011","journal-title":"Pain Med"},{"issue":"Suppl 1","key":"2022072009143903600_pnac093-B4","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1093\/pm\/pnab117","article-title":"Intraosseous basivertebral nerve radiofrequency ablation for the treatment of vertebral body endplate low back pain: Current evidence and future directions","volume":"22","author":"Michalik","year":"2021","journal-title":"Pain Med"},{"issue":"5","key":"2022072009143903600_pnac093-B5","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1007\/s00586-017-4955-4","article-title":"ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc\/bone marrow cross-talk with Modic changes","volume":"26","author":"Dudli","year":"2017","journal-title":"Eur Spine J"},{"issue":"3","key":"2022072009143903600_pnac093-B6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1469-7580.2010.01332.x","article-title":"Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra","volume":"218","author":"Bailey","year":"2011","journal-title":"J Anat"},{"issue":"1","key":"2022072009143903600_pnac093-B7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/s1529-9430(02)00455-2","article-title":"Substance P\u2013containing nerves within the human vertebral body. An immunohistochemical study of the basivertebral nerve","volume":"3","author":"Fras","year":"2003","journal-title":"Spine J"},{"issue":"3","key":"2022072009143903600_pnac093-B8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0033-1347298","article-title":"The role of the vertebral end plate in low back pain","volume":"3","author":"Lotz","year":"2013","journal-title":"Global Spine J"},{"issue":"6","key":"2022072009143903600_pnac093-B9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00002517-199812000-00013","article-title":"Innervation of the human vertebral body","volume":"11","author":"Antonacci","year":"1998","journal-title":"J Spinal Disord"},{"issue":"1","key":"2022072009143903600_pnac093-B10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1302\/0301-620X.79B1.0790147","article-title":"Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease","volume":"79","author":"Brown","year":"1997","journal-title":"J Bone Joint Surg Br"},{"issue":"13","key":"2022072009143903600_pnac093-B11","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1097\/00007632-200007010-00005","article-title":"Mechanical initiation of intervertebral disc degeneration","volume":"25","author":"Adams","year":"2000","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1 Pt 1","key":"2022072009143903600_pnac093-B12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1148\/radiology.166.1.3336678","article-title":"Degenerative disk disease: Assessment of changes in vertebral body marrow with MR imaging","volume":"166","author":"Modic","year":"1988","journal-title":"Radiology"},{"issue":"9","key":"2022072009143903600_pnac093-B13","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/01.brs.0000215027.87102.7c","article-title":"Tumor necrosis factor-immunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back pain and Modic Type 1 or Type 2 changes on MRI","volume":"31","author":"Ohtori","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"issue":"8","key":"2022072009143903600_pnac093-B14","doi-asserted-by":"crossref","first-page":"e0200677","DOI":"10.1371\/journal.pone.0200677","article-title":"Modic changes\u2014Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis","volume":"13","author":"Herlin","year":"2018","journal-title":"PLoS One"},{"issue":"14","key":"2022072009143903600_pnac093-B15","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/BRS.0b013e31828ce66d","article-title":"Magnetic resonance imaging predictors of surgical outcome in patients with lumbar intervertebral disc herniation","volume":"38","author":"Lurie","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"2022072009143903600_pnac093-B16","doi-asserted-by":"crossref","DOI":"10.1093\/pm\/pnac070","article-title":"The effectiveness of intraosseous basivertebral nerve radiofrequency ablation for the treatment of vertebrogenic low back pain: An updated systematic review with single arm meta-analysis","author":"Conger","year":"2022","journal-title":"Pain Med"},{"issue":"5","key":"2022072009143903600_pnac093-B17","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s00586-018-5496-1","article-title":"Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: A prospective randomized double-blind sham-controlled multi-center study","volume":"27","author":"Fischgrund","year":"2018","journal-title":"Eur Spine J"},{"issue":"10","key":"2022072009143903600_pnac093-B18","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.spinee.2019.05.598","article-title":"A prospective, randomized, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain","volume":"19","author":"Khalil","year":"2019","journal-title":"Spine J"},{"issue":"7","key":"2022072009143903600_pnac093-B19","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1007\/s00586-019-05995-2","article-title":"A prospective, open-label, single-arm, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain","volume":"28","author":"Truumees","year":"2019","journal-title":"Eur Spine J"},{"issue":"2","key":"2022072009143903600_pnac093-B20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.spinee.2016.08.032","article-title":"Ablation of the basivertebral nerve for treatment of back pain: A clinical study","volume":"17","author":"Becker","year":"2017","journal-title":"Spine J"},{"issue":"5","key":"2022072009143903600_pnac093-B21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00234-020-02577-8","article-title":"Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain","volume":"63","author":"De Vivo","year":"2021","journal-title":"Neuroradiology"},{"issue":"3","key":"2022072009143903600_pnac093-B22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14531\/ss2021.3.61-67","article-title":"Radiofrequency ablation of the basivertebral nerve in the treatment of chronic low back pain: Analysis of a small clinical series","volume":"18","author":"Fishchenko","year":"2021","journal-title":"Hir Pozvonochnika"},{"issue":"3","key":"2022072009143903600_pnac093-B23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/neuros\/nyz093","article-title":"Association between opioid use and patient-reported outcomes in a randomized trial evaluating basivertebral nerve ablation for the relief of chronic low back pain","volume":"86","author":"Markman","year":"2020","journal-title":"Neurosurgery"},{"issue":"2","key":"2022072009143903600_pnac093-B24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.14444\/6015","article-title":"Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 2-year results from a prospective randomized double-blind sham-controlled multicenter study","volume":"13","author":"Fischgrund","year":"2019","journal-title":"Int J Spine Surg"},{"issue":"8","key":"2022072009143903600_pnac093-B25","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00586-020-06448-x","article-title":"Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5 year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study","volume":"29","author":"Fischgrund","year":"2020","journal-title":"Eur Spine J"},{"issue":"100030","key":"2022072009143903600_pnac093-B26","first-page":"100030","article-title":"A prospective, open-label, single-arm, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results","volume":"3","author":"Macadaeg","year":"2020","journal-title":"NASSJ"},{"issue":"8","key":"2022072009143903600_pnac093-B27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/rapm-2020-102259","article-title":"A prospective, randomized, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results","volume":"46","author":"Smuck","year":"2021","journal-title":"Reg Anesth Pain Med"},{"key":"2022072009143903600_pnac093-B28","first-page":"100089","article-title":"Prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 24-month treatment arm results","volume":"8","author":"Koreckij","year":"2021","journal-title":"NASSJ"},{"issue":"11","key":"2022072009143903600_pnac093-B29","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/pm\/pnx121","article-title":"Guidelines for composing and assessing a paper on treatment of pain","volume":"18","author":"Bogduk","year":"2017","journal-title":"Pain Med"},{"issue":"7","key":"2022072009143903600_pnac093-B30","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/pm\/pny301","article-title":"Managing patient expectations is vital to successful pain management","volume":"20","author":"McCormick","year":"2019","journal-title":"Pain Med"},{"issue":"17","key":"2022072009143903600_pnac093-B31","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1097\/00007632-200109010-00011","article-title":"Magnetic resonance classification of lumbar intervertebral disc degeneration","volume":"26","author":"Pfirrmann","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"issue":"9","key":"2022072009143903600_pnac093-B32","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J Thorac Oncol"},{"key":"2022072009143903600_pnac093-B33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.wneu.2021.02.029","article-title":"Lumbar facet fluid-does it correlate with dynamic instability in degenerative spondylolisthesis? A systematic review and meta-analysis","volume":"149","author":"Aggarwal","year":"2021","journal-title":". World Neurosurg"},{"issue":"17","key":"2022072009143903600_pnac093-B34","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1097\/BRS.0b013e318113271a","article-title":"The significance of increased fluid signal on magnetic resonance imaging in lumbar facets in relationship to degenerative spondylolisthesis","volume":"32","author":"Chaput","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"issue":"10","key":"2022072009143903600_pnac093-B35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/BSD.0000000000000205","article-title":"Routine upright imaging for evaluating degenerative lumbar stenosis: Incidence of degenerative spondylolisthesis missed on supine MRI","volume":"28","author":"Segebarth","year":"2015","journal-title":"J Spinal Disord Tech"},{"key":"2022072009143903600_pnac093-B36","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.2147\/JPR.S227153","article-title":"Prevalence of facet effusion and its relationship with lumbar spondylolisthesis and low back pain: The Wakayama Spine Study","volume":"12","author":"Shinto","year":"2019","journal-title":"J Pain Res"},{"issue":"3","key":"2022072009143903600_pnac093-B37","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.spinee.2007.04.022","article-title":"Lumbar zygapophysial (facet) joint radiofrequency denervation success as a function of pain relief during diagnostic medial branch blocks: A multicenter analysis","volume":"8","author":"Cohen","year":"2008","journal-title":"Spine J"},{"issue":"1","key":"2022072009143903600_pnac093-B38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.ajp.0000210941.04182.ea","article-title":"Clinical predictors of success and failure for lumbar facet radiofrequency denervation","volume":"23","author":"Cohen","year":"2007","journal-title":"Clin J Pain"},{"issue":"2","key":"2022072009143903600_pnac093-B39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/AJP.0b013e3181b8cd4d","article-title":"MRI analysis of the lumbar spine: Can it predict response to diagnostic and therapeutic facet procedures?","volume":"26","author":"Stojanovic","year":"2010","journal-title":"Clin J Pain"},{"issue":"1","key":"2022072009143903600_pnac093-B40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/pm\/pnaa383","article-title":"The prevalence of \u201cpure\u201d lumbar zygapophysial joint pain in patients with chronic low back pain","volume":"22","author":"MacVicar","year":"2021","journal-title":"Pain Med"},{"issue":"3","key":"2022072009143903600_pnac093-B41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1526-4637.2009.00602.x","article-title":"Are outer annular fissures stimulated during diskography the source of diskogenic low-back pain? An analysis of analgesic diskography data","volume":"10","author":"DePalma","year":"2009","journal-title":"Pain Med"},{"issue":"5","key":"2022072009143903600_pnac093-B42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/BRS.0000000000004160","article-title":"Texture analysis of magnetic resonance images enables phenotyping of potentially painful annular fissures","volume":"47","author":"Eriksson","year":"2022","journal-title":"Spine (Phila Pa 1976)"},{"issue":"21","key":"2022072009143903600_pnac093-B43","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1097\/BRS.0000000000002721","article-title":"Endplate defect is heritable, associated with low back pain and triggers intervertebral disc degeneration: A longitudinal study from TwinsUK","volume":"43","author":"Munir","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"issue":"9","key":"2022072009143903600_pnac093-B44","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1007\/s00586-021-06865-6","article-title":"The association between vertebral endplate structural defects and back pain: A systematic review and meta-analysis","volume":"30","author":"Lawan","year":"2021","journal-title":"Eur Spine J"},{"issue":"5","key":"2022072009143903600_pnac093-B45","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/jor.24195","article-title":"Multidimensional vertebral endplate defects are associated with disc degeneration, Modic changes, facet joint abnormalities, and pain","volume":"37","author":"Zehra","year":"2019","journal-title":"J Orthop Res"},{"issue":"11","key":"2022072009143903600_pnac093-B46","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1007\/s00586-016-4459-7","article-title":"Pathobiology of Modic changes","volume":"25","author":"Dudli","year":"2016","journal-title":"Eur Spine J"},{"issue":"16","key":"2022072009143903600_pnac093-B47","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/BRS.0000000000002545","article-title":"Tidemark avulsions are a predominant form of endplate irregularity","volume":"43","author":"Berg-Johansen","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"issue":"10137","key":"2022072009143903600_pnac093-B48","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"Lancet Low Back Pain Series Working Group. What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"issue":"12","key":"2022072009143903600_pnac093-B49","doi-asserted-by":"crossref","first-page":"e009655","DOI":"10.1136\/bmjopen-2015-009655","article-title":"To what extent are surgery and invasive procedures effective beyond a placebo response? A systematic review with meta-analysis of randomised, sham controlled trials","volume":"5","author":"Jonas","year":"2015","journal-title":"BMJ Open"},{"key":"2022072009143903600_pnac093-B50","doi-asserted-by":"crossref","first-page":"370","DOI":"10.22203\/eCM.v041a24","article-title":"Intervertebral disc degeneration and regeneration: A motion segment perspective","volume":"41","author":"Ashinsky","year":"2021","journal-title":"Eur Cell Mater"},{"issue":"14","key":"2022072009143903600_pnac093-B51","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1097\/BRS.0000000000003035","article-title":"The relationship between endplate pathology and patient-reported symptoms for chronic low back pain depends on lumbar paraspinal muscle quality","volume":"44","author":"Bailey","year":"2019","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"2022072009143903600_pnac093-B52","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00586-012-2147-9","article-title":"Modic type I change may predict rapid progressive, deforming disc degeneration: a prospective 1-year follow-up study","volume":"21","author":"Kerttula","year":"2012","journal-title":"Eur Spine J"}],"container-title":["Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/painmedicine\/article-pdf\/23\/Supplement_2\/S34\/45029385\/pnac093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/painmedicine\/article-pdf\/23\/Supplement_2\/S34\/45029385\/pnac093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T02:49:55Z","timestamp":1676170195000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/painmedicine\/article\/23\/Supplement_2\/S34\/6646816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":52,"journal-issue":{"issue":"Supplement_2","published-online":{"date-parts":[[2022,7,20]]},"published-print":{"date-parts":[[2022,7,20]]}},"URL":"https:\/\/doi.org\/10.1093\/pm\/pnac093","relation":{},"ISSN":["1526-2375","1526-4637"],"issn-type":[{"value":"1526-2375","type":"print"},{"value":"1526-4637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,7,20]]}}}