{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:06:38Z","timestamp":1773885998130,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korean National Health Insurance Service"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To investigate the opioid consumption and the healthcare resource utilization in patients with the intrathecal drug delivery system (IDDS) therapy and the comprehensive medical management (CMM) alone.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A retrospective cohort study with a customized claims database.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n In a university-based hospital.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Patients with complex regional pain syndrome, post-laminectomy syndrome, and fibromyalgia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using propensity score matching (1:3), we selected patients with morphine infusion through IDDS (IDDS group) and CMM alone (CMM group). The primary endpoints were comparisons of average morphine equivalents daily dosages (MEDD, mg\/day) for 6 and 12\u2009months from an index date. The number of emergency room (ER) visits and hospitalizations and the total medical expenditures were compared as secondary outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In total, 82 patients (N\u2009=\u200923 in the IDDS group and N\u2009=\u200959 in the CMM group) were analyzed. Although a 6-month average MEDD did not reach statistical significance, a 12-month average MEDD was significantly decreased in the IDDS group compared to the CMM group (53.2\u2009\u00b1\u200946.3 vs 123.9\u2009\u00b1\u2009176.4, respectively; P\u2009=\u20090.008). ER visits were more frequent in the IDDS group than the CMM group at baseline (5.4 vs 0.5, respectively; P\u2009=\u2009.002), which was maintained for 12\u2009months (P\u2009&lt;\u20090.001). Otherwise, the number of hospitalization and the medical expenditures for pain management were not different between the groups for 12\u2009months.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The combined IDDS therapy had some benefits in reducing opioid consumption for 1-year follow-up compared to the CMM alone in chronic noncancer pain patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/pm\/pnac110","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T18:09:55Z","timestamp":1658858995000},"page":"79-88","source":"Crossref","is-referenced-by-count":4,"title":["Myth and Truth in Opioid Consumption with Intrathecal Morphine Pump Implantation in Chronic Pain: A Retrospective Cohort Study with Claims Database in South Korea"],"prefix":"10.1093","volume":"24","author":[{"given":"Yongjae","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Hospital , Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Hyeon","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Boramae Medical Center , Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haine","family":"Lee","sequence":"additional","affiliation":[{"name":"Healthcare Economics and Government Affairs, Medtronic Korea, Inc. , Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsook","family":"Choi","sequence":"additional","affiliation":[{"name":"Healthcare Economics and Government Affairs, Medtronic Korea, Inc. , Seoul, Republic of Korea"},{"name":"Department of Health Convergence, Ewha Womans University , Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somin","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Hospital , Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Hogyu","family":"Han","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine , Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7750","authenticated-orcid":false,"given":"Jee Youn","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Hospital , Seoul, Republic of Korea"},{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine , Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"issue":"10289","key":"2023010721332906300_pnac110-B1","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","article-title":"Chronic pain: An update on burden, best practices, and new advances","volume":"397","author":"Cohen","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"2023010721332906300_pnac110-B2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.36076\/ppj.2014\/17\/401","article-title":"Chronic opioid therapy for chronic non-cancer pain: A review and comparison of treatment guidelines","volume":"17","author":"Cheung","year":"2014","journal-title":"Pain Physician"},{"issue":"6","key":"2023010721332906300_pnac110-B3","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/ejp.1742","article-title":"Is opioid therapy for chronic non-cancer pain associated with a greater risk of all-cause mortality compared to non-opioid analgesics? 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