{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:43:41Z","timestamp":1780605821719,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Gr\u00fcnenthal GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>During routine clinical evaluation, it can be challenging to differentiate between lumbar radiculopathy (RAD) and lower back pain with non-radicular somatic referred pain (SRP) or even axial non-radiating low back pain (LBP). The aim of this study was to characterize patients with RAD, axial LBP (aLBP), and SRP on the basis of somatosensory profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with LBP (n\u2009=\u200954) were assessed with quantitative sensory testing in the area of LBP and, in cases of RAD, additionally in the area of projecting pain. Questionnaires (PainDETECT\u00ae, EuroQol-5D, Medical Outcomes Study Sleep Scale, Hannover Functional Ability Questionnaire for Back Pain, Roland Morris Disability Questionnaire, Short Form-12 Health Survey, and Hospital Anxiety and Depression Scale) were answered by all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with RAD (n\u2009=\u200912) had higher pain intensity scores (numeric rating scale: 5.7\u2009\u00b1\u20091.5 vs 4.1\u2009\u00b1\u20092.2; P\u2009&amp;lt;\u20090.05) and higher PainDETECT scores (14.6\u2009\u00b1\u20096.13 vs 9.7\u2009\u00b1\u20096.2; P\u2009&amp;lt;\u20090.05) than did patients with aLBP and SRP (n\u2009=\u200942). Patients with RAD had a more pronounced loss of small-fiber function, increased mechanical hyperalgesia, and a trend toward increased sensitivity to thermal pain in the area of LBP compared with patients with aLBP and SRP. Within patients with RAD, sensory profiles of the area of projecting pain and the area of LBP did not differ. Pressure pain hyperalgesia (measured by pressure pain threshold) and loss of mechanical detection (measured by mechanical detection threshold) in combination with the PainDETECT items numbness and prickling reached the best predictive value in detecting a radiculopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with RAD demonstrated more somatosensory abnormalities than did patients with aLBP and SRP, including increased mechanical hyperalgesia and a loss of mechanical detection. The combination of pressure pain threshold, mechanical detection threshold, numbness, and prickling in the area of LBP can be a time-efficient tool to identify patients with RAD.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnac129","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T15:30:29Z","timestamp":1663342229000},"page":"306-315","source":"Crossref","is-referenced-by-count":8,"title":["Sensory Profiles in Patients with Low Back Pain with and Without Radiculopathy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-8595","authenticated-orcid":false,"given":"Maren","family":"Reimer","sequence":"first","affiliation":[{"name":"Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein , Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Witth\u00f6ft","sequence":"additional","affiliation":[{"name":"Division 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Schleswig-Holstein , Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"H\u00fcllemann","sequence":"additional","affiliation":[{"name":"Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein , Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Binder","sequence":"additional","affiliation":[{"name":"Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein , Kiel, Germany"},{"name":"Department of Neurology, Saarbr\u00fccken Hospital , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Gierthm\u00fchlen","sequence":"additional","affiliation":[{"name":"Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein , Kiel, 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