{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:09:11Z","timestamp":1748938151518,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The study compared the efficacy and tolerability of piroxicam gel and a new topical combination of medicinal plant products (Soulagel\u00ae; Belpharma Tunisia) to treat pain caused by soft tissue injuries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients (n\u2009=\u20091,525) were assigned to receive piroxicam gel or Soulagel. Efficacy assessments included a change of at least 50% in the pain-on-movement visual numeric scale rating from emergency department discharge (baseline) to day\u00a07 final assessment, as well as the time required to reach pain resolution criteria, the need for rescue analgesia, patients\u2019 satisfaction, and the rate of adverse effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At day 7, 1,216 patients (79.7%) achieved at least 50% reduction in visual numeric scale rating from baseline: 623 patients (82.4%) in the Soulagel group vs 593 patients (77.1%) in the piroxicam group (P\u2009=\u20090.01). Time to decrease pain on movement by 50% was significantly higher with piroxicam gel than with Soulagel (34\u2009\u00b1\u20091 vs 33\u2009\u00b1\u20091\u2009days, respectively; P\u2009=\u20090.54). At day\u00a07, 96.4% of patients in the Soulagel group declared being \u201cvery satisfied\u201d to \u201csatisfied,\u201d vs 68% in the piroxicam group (P\u2009&amp;lt;\u20090.001). There were no major adverse events in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Soulagel is not inferior to piroxicam gel for managing pain related to a soft tissue injuries. Further studies will help ascertain whether this new gel offers an alternative treatment option for this common emergency department condition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnac176","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T21:48:07Z","timestamp":1667944087000},"page":"586-592","source":"Crossref","is-referenced-by-count":1,"title":["Analgesic Effect of Topical Piroxicam vs Phytotherapy Gel in the Treatment of Acute Soft Tissue Injuries: A Randomized Controlled Noninferiority Study"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-6679","authenticated-orcid":false,"given":"Khaoula","family":"Bel haj ali","sequence":"first","affiliation":[{"name":"Emergency Department, Fattouma Bourguiba University Hospital , Monastir, Tunisia"},{"name":"Research Laboratory LR12SP18, University of Monastir , Monastir, 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