{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:11:44Z","timestamp":1788923504606,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinical Research Center of University Hospitals Cleveland Medical Center"},{"name":"Case Western Reserve University Clinical and Translational Science Collaborative","award":["4UL1TR000439"],"award-info":[{"award-number":["4UL1TR000439"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intrathecal trialing is used as a screening prognostic measure prior to intrathecal drug delivery system implant. The purpose of this study was to determine the efficacy of a continuous intrathecal infusion of an admixture of bupivacaine and fentanyl in patients with chronic low back pain.<\/jats:p>\n               <jats:p>Patients with refractory chronic low back pain in the setting of previous lumbar spine surgery and\/or chronic vertebral compression fracture(s) were enrolled in a randomized double blind cross-over study comparing saline infusion to infusion of a solution containing bupivacaine combined with low-dose fentanyl over a 14\u201318\u2009hour period. The primary outcome measure was the change in pain intensity at the end of the screening trial. Patients who experienced significant pain reduction from either infusion relative to baseline pain were offered a permanent implant.<\/jats:p>\n               <jats:p>In total, 36 patients were enrolled, with 31 patients trialed and 25 implanted. At the end of the screening trial, pain scores, at rest or with activity, decreased appreciably in both groups; however, significantly better improvements occurred in the fentanyl\/bupivacaine group compared to saline both with activity and at rest (P\u2009=\u2009.016 and .006, respectively). Treatment order appeared to affect outcome with saline demonstrating a placebo response. At 12\u2009months following implant, primary and secondary outcome measures continued to be significantly reduced from baseline.<\/jats:p>\n               <jats:p>Continuous intrathecal delivery of a combination of zlow-dose fentanyl with bupivacaine is superior to saline in screening intrathecal trialing for back pain reduction. With longer term delivery, a sustained reduction of chronic low back pain was also observed.<\/jats:p>","DOI":"10.1093\/pm\/pnac195","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T22:45:42Z","timestamp":1670971542000},"page":"796-808","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Continuous Intrathecal Infusion Trialing with a Mixture of Fentanyl and Bupivacaine in Chronic Low Back Pain Patients"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-017X","authenticated-orcid":false,"given":"Salim M","family":"Hayek","sequence":"first","affiliation":[{"name":"Division of Pain Medicine, University Hospitals Cleveland Medical Center , Cleveland, Ohio, USA"},{"name":"Department of Anesthesiology\/Case Western Reserve University, University Hospitals Cleveland Medical Center , Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford 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