{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:14:17Z","timestamp":1786450457970,"version":"build-2736575974"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Research Priority Program (CRPP) Pain of the University of Zurich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Widespread pain hypersensitivity and enhanced temporal summation of pain (TSP) are commonly reported in patients with complex regional pain syndrome (CRPS) and discussed as proxies for central sensitization. This study aimed to directly relate such signs of neuronal hyperexcitability to the pain phenotype of CRPS patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-one CRPS patients and 20 healthy controls (HC) were recruited. The pain phenotype including spatial pain extent (assessed in % body surface) and intensity were assessed and related to widespread pain hypersensitivity, TSP, and psychological factors. Quantitative sensory testing (QST) was performed in the affected, the contralateral and a remote (control) area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CRPS patients showed decreased pressure pain thresholds in all tested areas (affected: t(34) \u2009=\u20094.98, P\u2009&amp;lt;\u2009.001, contralateral: t(35)\u2009=\u20093.19, P\u2009=\u2009.005, control: t(31)\u2009=\u20092.65, P\u2009=\u2009.012). Additionally, patients showed increased TSP in the affected area (F(3,111)\u2009=\u20094.57, P\u2009=\u2009.009) compared to HC. TSP was even more enhanced in patients with a high compared to a low spatial pain extent (F(3,51)\u2009=\u20095.67, P\u2009=\u2009.008), suggesting pronounced spinal sensitization in patients with extended pain patterns. Furthermore, the spatial pain extent positively correlated with the Bath Body Perception Disturbance Scale (\u03c1\u2009=\u20090.491; P\u2009=\u2009.048).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, we provide evidence that the pain phenotype in CRPS, that is, spatial pain extent, might be related to sensitization mechanism within the central nociceptive system. This study points towards central neuronal excitability as a potential therapeutic target in patients with more widespread CRPS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnad040","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T11:46:05Z","timestamp":1679485565000},"page":"974-984","source":"Crossref","is-referenced-by-count":23,"title":["Central sensitization in CRPS patients with widespread pain: a cross-sectional study"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-6565","authenticated-orcid":false,"given":"Iara","family":"De Schoenmacker","sequence":"first","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich , 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mollo","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich , 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-0133","authenticated-orcid":false,"given":"Paulina Simonne","family":"Scheuren","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich , 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-3546","authenticated-orcid":false,"given":"Laura","family":"Sirucek","sequence":"additional","affiliation":[{"name":"Integrative Spinal Research, Department of Chiropractic Medicine, University Hospital Balgrist, University of Zurich , 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-3824","authenticated-orcid":false,"given":"Florian","family":"Brunner","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rheumatology, Balgrist University Hospital , 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schweinhardt","sequence":"additional","affiliation":[{"name":"Integrative Spinal Research, Department of Chiropractic Medicine, University Hospital Balgrist, University of Zurich , 8008 Zurich, Switzerland"},{"name":"Alan Edward Center for Research on Pain, McGill University , Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Curt","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich , 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rosner","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich , 8008 Zurich, Switzerland"},{"name":"Department of Neurology, University Hospital Bern, Inselspital, 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