{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:41:48Z","timestamp":1781707308446,"version":"3.54.5"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Guangxi Natural Science Foundation Program, China","award":["2019GXNSFBA185025"],"award-info":[{"award-number":["2019GXNSFBA185025"]}]},{"name":"Doctoral Scientific Research Start-up Funding of Guangxi University of Traditional Chinese Medicine","award":["2018BS051"],"award-info":[{"award-number":["2018BS051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Second fractures at the cemented vertebrae (SFCV) are often seen after percutaneous kyphoplasty, especially at the thoracolumbar junction. Our study aimed to develop and validate a preoperative clinical prediction model for predicting SFCV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of 224 patients with single-level thoracolumbar osteoporotic vertebral fractures (T11\u2013L2) from 3 medical centers was analyzed between January 2017 and June 2020 to derive a preoperative clinical prediction model for SFCV. Backward-stepwise selection was used to select preoperative predictors. We assigned a score to each selected variable and developed the SFCV scoring system. Internal validation and calibration were conducted for the SFCV score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 224 patients included, 58 had postoperative SFCV (25.9%). The following preoperative measures on multivariable analysis were summarized in the 5-point SFCV score: bone mineral density (\u2264\u20133.05), serum 25-hydroxy vitamin D3 (\u226417.55\u2009ng\/mL), standardized signal intensity of fractured vertebra on T1-weighted images (\u226459.52%), C7\u2013S1 sagittal vertical axis (\u22653.25\u2009cm), and intravertebral cleft. Internal validation showed a corrected area under the curve of 0.794. A cutoff of \u22641 point was chosen to classify a low risk of SFCV, for which only 6 of 100 patients (6%) had SFCV. A cutoff of \u22654 points was chosen to classify a high risk of SFCV, for which 28 of 41 (68.3%) had SFCV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The SFCV score was found to be a simple preoperative method for identification of patients at low and high risk of postoperative SFCV. This model could be applied to individual patients and aid in the decision-making before percutaneous kyphoplasty.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnad044","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T18:14:10Z","timestamp":1680632050000},"page":"949-956","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of subsequent vertebral compression fractures after thoracolumbar kyphoplasty: a multicenter retrospective analysis"],"prefix":"10.1093","volume":"24","author":[{"given":"Weibo","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Third Affiliated Hospital of Southern Medical University , Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Third Affiliated Hospital of Southern Medical University 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