{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:25:57Z","timestamp":1790267157689,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Faculty of Medicine, Universitas Airlangga","award":["244\/UN3.1.1\/PT\/2021"],"award-info":[{"award-number":["244\/UN3.1.1\/PT\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate interleukin (IL)-1\u03b2, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eighty-seven women were diagnosed with endometriosis or cases related to infertility. IL-1\u03b2, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid were determined by enzyme-linked immunosorbent assay (ELISA). Pain assessment was evaluated by the Visual Analog Scale (VAS) score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Serum IL-6 and IL-12p70 levels increased in women with endometriosis compared to the control group. Serum and peritoneal IL-8 and IL-12p70 levels correlated with VAS scores in infertile women. A positive correlation was also found between peritoneal IL-1\u03b2 and IL-6 with VAS score. A significant difference in peritoneal IL-1\u03b2 levels was associated with menstrual pelvic pain, while peritoneal IL-8 levels were related to dyspareunia, menstrual, and post-menstrual pelvic pain in infertile women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>An association of IL-8 and IL-12p70 levels were related to pain in endometriosis, as well as a relationship between cytokine expression and VAS score. Further studies should be addressed to investigate the precise mechanism of cytokine-related pain in endometriosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnad080","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T15:21:12Z","timestamp":1686928872000},"page":"1262-1269","source":"Crossref","is-referenced-by-count":27,"title":["IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis"],"prefix":"10.1093","volume":"24","author":[{"given":"Nanda Yuli","family":"Rahmawati","sequence":"first","affiliation":[{"name":"Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga , 60286 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-3804","authenticated-orcid":false,"given":"Fadhil","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, 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