{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:46:17Z","timestamp":1790199977599,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the safety and tolerability of MRI-guided focused ultrasound (MRgFUS) for the treatment of facet joint\u2013mediated pain in human subjects for whom conventional treatment had failed. Secondarily, to evaluate effectiveness of the procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive patients who underwent MRgFUS at our institution were retrospectively identified. Chart review was performed to obtain relevant clinical and technical data. All patients had chronic low back pain and positive comparative medial branch blocks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-six MRgFUS treatments in 20 patients were included. Mean sonication energy was 1436.6 Joules. The procedure was technically successful in all patients. Of the treated patients, 29.6% experienced short-term worsening of low back pain immediately after the procedure, all by 1\u20134 points on a 0\u201310 scale. One patient (3.8%) reported temporary worsening of preexisting radicular symptoms after the procedure. Of 21 treatments with clinical follow-up of at least 3\u2009months available, 12 (57.1%) had &amp;gt;3\u2009months\u2019 pain relief, 2 (10%) had &amp;lt;3\u2009months\u2019 benefit, 6 (30%) reported no benefit, and 1 (5%) patient was lost to follow-up. In patients who reported at least some benefit with prior conventional radiofrequency ablation, 8\/10 (80%) benefited from the MRgFUS procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The present study demonstrates that MRgFUS ablation of the lumbar facet joints is a safe and tolerable procedure in human subjects and could provide another option for patients for whom radiofrequency ablation had failed. More than half of all patients received significant durable pain relief, which jumped to 80% for patients who had experienced at least some benefit from prior radiofrequency ablations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnad100","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T19:14:57Z","timestamp":1689966897000},"page":"1219-1223","source":"Crossref","is-referenced-by-count":19,"title":["MRI-guided focused ultrasound ablation of painful lumbar facet joints: a retrospective assessment of safety and tolerability in human subjects"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-6003","authenticated-orcid":false,"given":"Christin A","family":"Tiegs-Heiden","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina K","family":"Hesley","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiyang","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J","family":"Lamer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof R","family":"Gorny","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Hangiandreou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance T","family":"Lehman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"issue":"4","key":"2023110711495252100_pnad100-B1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrrheum.2012.199","article-title":"Osteoarthritis of the spine: the facet joints","volume":"9","author":"Gellhorn","year":"2013","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"2023110711495252100_pnad100-B2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.mayocp.2015.10.009","article-title":"Evaluation and treatment of low back pain: a clinically focused review for primary care specialists","volume":"90","author":"Hooten","year":"2015","journal-title":"Mayo Clin Proc"},{"issue":"10","key":"2023110711495252100_pnad100-B3","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/00007632-199405001-00006","article-title":"Clinical features of patients with pain stemming from the lumbar zygapophysial joints. 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