{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:22:06Z","timestamp":1791390126262,"version":"4.3.3"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This case series retrospectively reviewed the outcomes in patients implanted with combined, synchronous dorsal root ganglion stimulation (DRGS) and spinal cord stimulation (SCS) connected to a single implantable pulse generator (IPG) in a tertiary referral neuromodulation centre in the United Kingdom.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-six patients underwent a trial of DRGS+SCS for treating focal neuropathic pain between January 2016 and December 2019, with a follow-up in February 2022. A Transgrade approach was employed for DRGS. Patients were provided with 3 possible stimulation programs: DRGS-only, SCS-only, or DRGS+SCS. Patients were assessed for pain intensity, patients\u2019 global impression of change (PGIC), preferred lead(s) and complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty patients were successful and went on for full implantation. The most common diagnosis was Complex Regional Pain Syndrome. After an average of 3.1\u2009years follow-up, 1 patient was lost to follow-up, and 2 were non-responders. Of the remaining 17 patients, 16 (94%) continued to report a PGIC of 7. The average pain intensity at Baseline was 8.5 on an NRS scale of 0\u201310. At the last follow-up, the average NRS reduction overall was 78.9% with no statistical difference between those preferring DRGS+SCS (n\u2009=\u20099), SCS-only (n\u2009=\u20093) and DRGS-only (n\u2009=\u20095). The combination of DRGS+SCS was preferred by 53% at the last follow-up. There were no serious neurological complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This retrospective case series demonstrates the potential effectiveness of combined DRGS+SCS with sustained analgesia observed at an average follow-up of over 3 years. Implanting combined DRGS+SCS may provide programming flexibility and therapeutic alternatives.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnad128","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T20:39:22Z","timestamp":1695415162000},"page":"116-124","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of combined dorsal root ganglion and spinal cord stimulation: a retrospective, single-centre case series for chronic focal neuropathic pain"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-6251","authenticated-orcid":false,"given":"Cormac F","family":"Mullins","sequence":"first","affiliation":[{"name":"Pain Management Department, Gassiot House, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London SE1 7EH, United Kingdom"},{"name":"Department of Pain Medicine, South Infirmary Victoria University Hospital , Cork T12X23H, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano Joseph","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Pain Management Department, Gassiot House, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London SE1 7EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephany","family":"Harris","sequence":"additional","affiliation":[{"name":"Pain Management Department, Gassiot House, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London SE1 7EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Al-Kaisy","sequence":"additional","affiliation":[{"name":"Pain Management Department, Gassiot House, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London SE1 7EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Wesley","sequence":"additional","affiliation":[{"name":"Pain Management Department, Gassiot 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