{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T01:16:15Z","timestamp":1745370975908,"version":"3.37.3"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HD082302"],"award-info":[{"award-number":["HD082302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institutional Internationalization Program","award":["CAPES\/PrInt\/UFSCar"],"award-info":[{"award-number":["CAPES\/PrInt\/UFSCar"]}]},{"name":"Brazilian Federal Agency for Support and Evaluation of Graduate Education"},{"name":"Ministry of Education of Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To explore the relationship between sociodemographic, clinical, and neurophysiological variables and health-related quality of life (HR-QOL) of patients with phantom limb pain (PLP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a cross-sectional analysis of a previous clinical trial. Univariate and multivariate linear and logistic regression analyses were used to model the predictors of HR-QOL. We utilized a sequential modeling approach with increasing adjustment levels, controlling for age and sex, and other relevant clinical variables (time since amputation, level of amputation, and pain). HR-QOL was assessed by the SF-36 Health Survey and its 8 subdomains.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We analyzed baseline data from 92 patients with lower-limb amputations. They were mostly male (63%), 45.2\u2009\u00b1\u200915.6\u2009years, with a mean time since amputation of 82.7\u2009\u00b1\u2009122.4\u2009months, and an overall SF-36 score of 55.9\u2009\u00b1\u200921.5. We found an association between intracortical facilitation (ICF) in the affected hemisphere, gabapentin usage, and HR-QOL. ICF is a predictor of better HRQOL, whereas gabapentin usage was associated with a poorer HR-QOL, with the main model explaining 13.4% of the variance in the outcome. For the SF-36 subdomains, ICF was also a positive predictor for social functioning, bodily pain, and vitality, while medication usage was associated with lower scores in mental health, general health perception, bodily pain, and vitality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We found firsthand 2 new independent predictors of HR-QOL in individuals with PLP, namely, the neurophysiological metric ICF and gabapentin usage. These results highlight the role of the motor cortex excitability in the HR-QOL and stress the need for treatments that favor the neuroplastic adaptation after amputation, for which ICF may be used as a possible marker.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnae053","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T22:48:20Z","timestamp":1720133300000},"page":"679-686","source":"Crossref","is-referenced-by-count":1,"title":["Neuropsychiatric drugs and a neurophysiological marker as predictors of health-related quality of life in patients with phantom limb pain"],"prefix":"10.1093","volume":"25","author":[{"given":"Valton","family":"Costa","sequence":"first","affiliation":[{"name":"Laboratory of Neurosciences and Neurological Rehabilitation, Physical Therapy Department, Federal University of Sao Carlos , Sao Carlos, SP, 13565-905,","place":["Brazil"]},{"name":"Neuromodulation Center and Center for Clinical Research Learning, 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13565-905,","place":["Brazil"]},{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School , Boston, MA 02129,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-9355","authenticated-orcid":false,"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School , Boston, MA 02129,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"issue":"1","key":"2024110408464762300_pnae053-B1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/ejp.1657","article-title":"Prevalence and incidence of phantom limb pain, phantom 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