{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:56:04Z","timestamp":1792122964569,"version":"4.4.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Grant for Research Advancement on Palliative Medicine"},{"DOI":"10.13039\/100024212","name":"Japanese Society for Palliative Medicine","doi-asserted-by":"publisher","award":["201"],"award-info":[{"award-number":["201"]}],"id":[{"id":"10.13039\/100024212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the efficacy and safety of a single trigger point injection (TPI) of a local anesthetic for the treatment of myofascial pain syndrome (MPS) in patients with incurable cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicenter, exploratory, open-label, randomized comparative trial was conducted in five specialized palliative care departments. Hospitalized patients with incurable cancer who had been experiencing pain related to MPS were randomized to receive either a TPI of 1% lidocaine plus conventional care (TPI group) or conventional care alone (control group). The short-term efficacy and occurrence of adverse events (AEs) were compared between groups. The primary endpoint was the percentage of patients who experienced a reduction in pain scores of \u226550%, assessed using an 11-point Numerical Rating Scale, at 3\u2009days post-intervention. Adverse events were assessed using the Common Terminology Criteria for AEs v5.0.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty patients were enrolled, and the trial completion rate was 100%. The proportion of patients who experienced an improvement in Numerical Rating Scale pain scores of \u226550% was 70.8% (95% confidence interval, 52.4%-89.2%) in the TPI group and 0.0% in the control group; the difference was statistically significant (P\u2009&amp;lt;\u2009.001). In the TPI group, one case (4.2%) of Grade 1 nausea and 1 case (4.2%) of Grade 1 somnolence were reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A single TPI of a local anesthetic is safe and efficacious in inducing an immediate reduction in MPS-related pain in patients with incurable cancer.<\/jats:p>\n                  <jats:p>Clinical trials registration number: This study was registered with the Japan Registry of Clinical Trials (approval number: jRCTs051210132) on December 16, 2021. https:\/\/jrct.niph.go.jp\/en-latest-detail\/jRCTs051210132.<\/jats:p>\n                  <jats:p>Approval of the research protocol by a Certified Review Board: The present study was approved by the Wakayama Medical University (reference number: CRB5180004. Registered 26 May 2021).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnae084","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:45:07Z","timestamp":1728575107000},"page":"14-21","source":"Crossref","is-referenced-by-count":5,"title":["Trigger point injections for myofascial pain in terminal cancer: a randomized trial"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-9029","authenticated-orcid":false,"given":"Hideaki","family":"Hasuo","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Medicine, Kansai Medical University , Osaka, Hirakata, Osaka, 573-1010,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Ishiki","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, National Cancer Center Hospital , Tokyo, 104-0045,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-9377","authenticated-orcid":false,"given":"Yoshinobu","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, NHO Kinki-Chuo Chest Medical Center , Sakai, 591-8555,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-1971","authenticated-orcid":false,"given":"Hiromichi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Psycho-Oncology, National Cancer Center Hospital , Tokyo, 104-0045,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, National Cancer Center Hospital East , Kashiwa, 277-8577,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kansai Medical University , Osaka, Hirakata, Osaka, 573-1010,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kansai Medical University , Osaka, Hirakata, Osaka, 573-1010,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-4818","authenticated-orcid":false,"given":"Yoshihisa","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Palliative Therapy, Cancer Institute Hospital of Japanese Foundation for Cancer Research , Tokyo, 135-0063,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine , Kyoto, 602-8566,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"issue":"9","key":"2025010608382981700_pnae084-B1","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of patients with cancer: A systematic review of the past 40 years","volume":"18","author":"van den Beuken-van Everdingen","year":"2007","journal-title":"Ann Oncol"},{"issue":"3","key":"2025010608382981700_pnae084-B2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/SPC.0000000000000446","article-title":"Interventions for myofascial pain syndrome in cancer pain: Recent advances: why, when, 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