{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:14:14Z","timestamp":1790100854780,"version":"4.0.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Chemical neurolysis of the genicular nerves is a treatment option for intractable non-cancer knee pain. This scoping review synthesizes the available literature on the effectiveness, adverse events, and procedural techniques of chemical neurolysis of genicular nerves for the management of knee pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Scoping review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>All clinical and research settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>Adult participants with chronic non-cancer knee pain undergoing chemical neurolysis of genicular nerves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A literature search in MEDLINE, EMBASE, and Cochrane Library was conducted up to September 4, 2023. Articles were searched via terms and keywords relating to \u201cknee,\u201d \u201cpain,\u201d \u201cknee osteoarthritis,\u201d \u201cablation,\u201d \u201calcohol,\u201d \u201cphenol,\u201d and \u201cchemical neurolysis.\u201d Included articles were full-text primary studies and in English. Data were extracted by 2 independent reviewers using an electronic database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight studies were included in this review (including 1 randomized controlled trial), comprising 192 patients. Of the 8 studies, 4 used phenol, 3 used alcohol, and 1 used either alcohol or phenol for chemical neurolysis. Fluoroscopy, ultrasound guidance, or both were used for nerve target identification. All studies demonstrated that chemical neurolysis resulted in improved pain or functional outcomes, with no serious adverse events reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Chemical neurolysis of the genicular nerves is a promising treatment strategy for chronic knee pain. Interpretation of the available studies is limited by study heterogeneity and small sample sizes. High-quality randomized controlled trials are required to clarify the selection of appropriate nerve targets and choice of image guidance and to compare with other ablative modalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study registration<\/jats:title>\n                  <jats:p>Open Science Framework (https:\/\/osf.io\/jg8wh).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnae109","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:32:41Z","timestamp":1730309561000},"page":"76-89","source":"Crossref","is-referenced-by-count":6,"title":["Chemical neurolysis of genicular nerves for chronic non-cancer knee pain: a scoping review"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-539X","authenticated-orcid":false,"given":"Matthew Rong Jie","family":"Tay","sequence":"first","affiliation":[{"name":"Toronto Rehabilitation Institute, University Health Network , Toronto, Ontario M5G2A2,","place":["Canada"]},{"name":"Department of Rehabilitation Medicine, Tan Tock Seng Hospital , Singapore 308433,","place":["Singapore"]},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-1956","authenticated-orcid":false,"given":"Nimish","family":"Mittal","sequence":"additional","affiliation":[{"name":"Toronto Rehabilitation Institute, University Health Network , Toronto, Ontario M5G2A2,","place":["Canada"]},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto , Toronto, Ontario M5S3H2,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Yao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, Newfoundland A1B3V6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Farag","sequence":"additional","affiliation":[{"name":"Toronto Rehabilitation Institute, University Health Network , Toronto, Ontario M5G2A2,","place":["Canada"]},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto , Toronto, Ontario M5S3H2,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"2025020317411018800_pnae109-B1","doi-asserted-by":"crossref","first-page":"100587","DOI":"10.1016\/j.eclinm.2020.100587","article-title":"Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies","volume":"29-30","author":"Cui","year":"2020","journal-title":"EClinicalMedicine"},{"issue":"10053","key":"2025020317411018800_pnae109-B2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Vos","year":"2016","journal-title":"Lancet"},{"issue":"10158","key":"2025020317411018800_pnae109-B3","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(18)32344-4","article-title":"Knee replacement","volume":"392","author":"Price","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"2025020317411018800_pnae109-B4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/acr.24131","article-title":"American College of Rheumatology\/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"9","key":"2025020317411018800_pnae109-B5","first-page":"e721","article-title":"AAOS clinical practice guideline summary: management of osteoarthritis of the knee (nonarthroplasty), third edition","volume":"30","author":"Brophy","year":"2022","journal-title":"J Am Acad Orthop Surg"},{"key":"2025020317411018800_pnae109-B6","first-page":"1745","article-title":"Health related quality of life outcomes after total hip and knee arthroplasties in a community based population","volume":"27","author":"Jones","year":"2000","journal-title":"J Rheumatol"},{"issue":"1","key":"2025020317411018800_pnae109-B7","doi-asserted-by":"crossref","first-page":"e000435","DOI":"10.1136\/bmjopen-2011-000435","article-title":"What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? 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